| Gene Symbol | RAGE |
| Aliases | Receptor for Advanced Glycation End Products |
| Protein Type | Receptor |
| Function | In the healthy nervous system, RAGE participates in: - Development: Neuronal differentiation and migration during embryonic development - Repair: Tissue repair and regeneration following injury - Infl |
| Primary Expression | hippocampus, cortex, spinal cord, Thalamus, Hypothalamus |
| Subcellular Localization | </th><td>Cell surface (membrane), cytoplasm, nucleus</td></tr> |
| Molecular Weight | 45 kDa |
| Pathways | NF-κB, MAPK pathway, NF-κB signaling |
| GeneCards | RAGE |
| Human Protein Atlas | RAGE |
| Extracellular domain | One V-type immunoglobulin domain (responsible for ligand binding) and two C-type domains |
| Transmembrane domain | Single-pass transmembrane helix |
| Intracellular domain | Cytoplasmic tail required for signal transduction |
| Development | Neuronal differentiation and migration during embryonic development |
| Repair | Tissue repair and regeneration following injury |
| Associated Diseases | Aging, Als, Alzheimer, Atherosclerosis, cancer |
| Known Drugs/Compounds | metformin, RAPAMYCIN, resveratrol, RESVERATROL |
| Interactions | ABCA1, ACHE, AD, ADAM10, AGER, AGING |
| KG Connections | 1328 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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