protein

CATHEPSIN B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CATHEPSIN B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

35Connections

3Hypotheses

1Analyses

17Outgoing

18Incoming

0Experiments

1Debates

Summary

Cathepsin B, lysosomal protease in neurodegeneration

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🔬 Protein Info

Gene Symbol	CATHEPSIN B
Molecular Weight	38 kDa
Amino Acids	339 aa
Interactions	ACTB, ALZHEIMER, ATG7, CTSB, CTSD, LAMP1
KG Connections	30 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    CATHEPSIN_B["CATHEPSIN B"]
    ATG7["ATG7"]
    CATHEPSIN_B -->|"activates"| ATG7
    TUBULIN["TUBULIN"]
    CATHEPSIN_B -->|"activates"| TUBULIN
    SYNAPSIN_I["SYNAPSIN I"]
    CATHEPSIN_B -->|"activates"| SYNAPSIN_I
    ALZHEIMER["ALZHEIMER"]
    CATHEPSIN_B -->|"activates"| ALZHEIMER
    Genes["Genes"]
    CATHEPSIN_B -->|"activates"| Genes
    LYSOSOME["LYSOSOME"]
    CATHEPSIN_B -->|"activates"| LYSOSOME
    Alzheimer_Disease["Alzheimer Disease"]
    CATHEPSIN_B -->|"activates"| Alzheimer_Disease
    disease["disease"]
    CATHEPSIN_B -->|"activates"| disease
    DMSO["DMSO"]
    CATHEPSIN_B -->|"activates"| DMSO
    PRKAA["PRKAA"]
    CATHEPSIN_B -->|"activates"| PRKAA
    Infection["Infection"]
    CATHEPSIN_B -->|"activates"| Infection
    Proteins["Proteins"]
    CATHEPSIN_B -->|"activates"| Proteins
    RAPAMYCIN["RAPAMYCIN"]
    CATHEPSIN_B -->|"activates"| RAPAMYCIN
    AUTOPHAGOSOME["AUTOPHAGOSOME"]
    CATHEPSIN_B -->|"activates"| AUTOPHAGOSOME
    Proteins["Proteins"]
    CATHEPSIN_B -->|"expressed in"| Proteins
    TFEB["TFEB"]
    TFEB -->|"activates"| CATHEPSIN_B
    ACTB["ACTB"]
    ACTB -->|"activates"| CATHEPSIN_B
    Autophagy["Autophagy"]
    Autophagy -->|"activates"| CATHEPSIN_B
    CTSD["CTSD"]
    CTSD -->|"activates"| CATHEPSIN_B
    SQSTM1["SQSTM1"]
    SQSTM1 -->|"activates"| CATHEPSIN_B
    mTOR["mTOR"]
    mTOR -->|"activates"| CATHEPSIN_B
    MAP1LC3B["MAP1LC3B"]
    MAP1LC3B -->|"activates"| CATHEPSIN_B
    SYT1["SYT1"]
    SYT1 -->|"activates"| CATHEPSIN_B
    MAP2["MAP2"]
    MAP2 -->|"activates"| CATHEPSIN_B
    SNAP25["SNAP25"]
    SNAP25 -->|"activates"| CATHEPSIN_B
    TUBB3["TUBB3"]
    TUBB3 -->|"activates"| CATHEPSIN_B
    CTSB["CTSB"]
    CTSB -->|"activates"| CATHEPSIN_B
    SYN1["SYN1"]
    SYN1 -->|"activates"| CATHEPSIN_B
    RIBOSOMAL_PROTEIN_S6["RIBOSOMAL PROTEIN S6"]
    RIBOSOMAL_PROTEIN_S6 -->|"activates"| CATHEPSIN_B
    LAMP1["LAMP1"]
    LAMP1 -->|"activates"| CATHEPSIN_B

Outgoing (17)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00
NLRP3 inflammasome	activates	pathway	0.90
NLRP3	activates	protein	0.80
SYNAPSIN I	activates	protein	0.50
ALZHEIMER	activates	gene	0.50
LYSOSOME	activates	gene	0.50
Alzheimer Disease	activates	disease	0.50
disease	activates	disease	0.50
ATG7	activates	protein	0.50
PRKAA	activates	concept	0.50
Infection	activates	disease	0.50
Proteins	activates	protein	0.50
RAPAMYCIN	activates	concept	0.50
AUTOPHAGOSOME	activates	concept	0.50
DMSO	activates	concept	0.50
TUBULIN	activates	protein	0.50
Proteins	expressed_in	protein	0.50

Incoming (18)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00
RAGE	activates	protein	0.80
CERULOPLASMIN	expressed_in	protein	0.50
TFEB	activates	protein	0.50
ACTB	activates	gene	0.50
Autophagy	activates	process	0.50
CTSD	activates	gene	0.50
SQSTM1	activates	gene	0.50
mTOR	activates	entity	0.50
MAP1LC3B	activates	gene	0.50
SYT1	activates	gene	0.50
MAP2	activates	gene	0.50
SNAP25	activates	gene	0.50
TUBB3	activates	gene	0.50
CTSB	activates	gene	0.50
SYN1	activates	gene	0.50
RIBOSOMAL PROTEIN S6	activates	protein	0.50
LAMP1	activates	protein	0.50

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
PD-Associated GWAS Variants in CTSO and CTSF Genes Create a	0.743	neurodegeneration	-
Dual Calpain/Cathepsin B Inhibition as Primary Neuroprotecti	0.644	neurodegeneration	Why does autophagy inhibition improve ne
Selective cathepsin B inhibition prevents cathepsin leakage-	0.620	neuroscience	Lysosomal dysfunction and cathepsin leak

Mentioning Analyses (1)

Scientific analyses that reference this entity

Lysosomal dysfunction and cathepsin leakage in Alzheimer disease progression

neuroscience | 2026-04-04 | 7 hypotheses Top: 0.679

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Lysosomal membrane permeabilization releasing cathepsins triggers NLRP3 inflamma

closed · Rounds: 4 · Score: 0.76 · 2026-04-22

Related Research

Hypotheses and analyses mentioning CATHEPSIN B in their description or question text

No additional research found