| Gene Symbol | SQSTM1 |
| Full Name | SQSTM1 (p62/Sequestosome-1) |
| Chromosome | 5q35.3. |
| Protein Type | Protein |
| Function | p62/SQSTM1 functions as: [@jones2021] |
| Molecular Weight | ~62 kDa (hence p62) |
| Pathways | Adaptive Immunity, Akt, Autophagy, Autophagy-lysosomal pathway, Cell Cycle |
| UniProt ID | Q13501 |
| GeneCards | SQSTM1 |
| Human Protein Atlas | SQSTM1 |
| LC3 (MAP1LC3B) | Primary autophagosomal marker that interacts with p62 |
| NBR1 | Neighbor of BRCA1 gene product; related selective autophagy receptor |
| TDP-43 | RNA-binding protein whose aggregates accumulate with p62 in ALS |
| Alpha-synuclein | Parkinson's disease-related protein that accumulates with p62 |
| mTOR | Nutrient-sensing kinase regulated by p62 |
| Associated Diseases | AD, ADH, Aging, ALI, Als |
| Known Drugs/Compounds | ATC161, COENZYME Q10, DEXAMETHASONE, N-degrons, Palmostatin B, rapamycin |
| Interactions | 4E-BP1, ABCA1, ABCD3, ABCG1, ACAT1, ACHE |
| SciDEX Hypotheses | Rutin enhances chaperone and autophagic clearance Astrocytic SQSTM1 Overexpression Therapy Cross-Seeding Autophagy Specificity Enhancement |
| KG Connections | 4054 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!