Mitochondrial SPM Synthesis Compartmentalization
🧪 Overview
SPM synthesis enzymes could be targeted to mitochondria in microglia to create high local concentrations at sites of oxidative stress and energy dysfunction, directly coupling resolution to metabolic rescue.
Debate provenance: derived from debate `sess_sda-2026-04-01-gap-014` on question: SPMs (resolvins, protectins, maresins) from omega-3s may promote inflammation resolution. Are resolution failures druggable?. Consensus signal: domain_expert, skeptic, synthesizer, theorist discussed the mechanism terms ALOX15, Compartmentalization, Mitochondrial, SPM, Synthesis, mitochondrial. Novelty signal: skeptic-discussed-with-qualified-concession.
🧬 Mechanism
Auto-built from this analysis's top knowledge-graph edges.
graph TD
ALOX15["ALOX15"] -->|encodes| n15_lipoxygenase["15-lipoxygenase"]
ALOX15_1["ALOX15"] -->|participates in| Astrocyte_reactivity_sign["Astrocyte reactivity signaling"]
BMAL1["BMAL1"] -->|co discussed| ALOX15_2["ALOX15"]
ALOX15_3["ALOX15"] -->|co discussed| CLOCK["CLOCK"]
ALOX15_4["ALOX15"] -->|co discussed| TFRC["TFRC"]
ALOX15_5["ALOX15"] -->|co discussed| GPR37["GPR37"]
ALOX15_6["ALOX15"] -->|co discussed| CMKLR1["CMKLR1"]
ALOX15_7["ALOX15"] -->|co discussed| ALOX12["ALOX12"]
ALOX15_8["ALOX15"] -->|co discussed| TREM2["TREM2"]
ALOX15_9["ALOX15"] -->|co discussed| AADC["AADC"]
ALOX15_10["ALOX15"] -->|co discussed| BCL2L1["BCL2L1"]
CMKLR1_11["CMKLR1"] -->|co discussed| ALOX15_12["ALOX15"]
ALOX12_13["ALOX12"] -->|co discussed| ALOX15_14["ALOX15"]
ALOX5["ALOX5"] -->|co discussed| ALOX15_15["ALOX15"]
GPR37_16["GPR37"] -->|co discussed| ALOX15_17["ALOX15"]
style ALOX15 fill:#ce93d8,stroke:#333,color:#000
style n15_lipoxygenase fill:#4fc3f7,stroke:#333,color:#000
style ALOX15_1 fill:#ce93d8,stroke:#333,color:#000
style Astrocyte_reactivity_sign fill:#81c784,stroke:#333,color:#000
style BMAL1 fill:#ce93d8,stroke:#333,color:#000
style ALOX15_2 fill:#ce93d8,stroke:#333,color:#000
style ALOX15_3 fill:#ce93d8,stroke:#333,color:#000
style CLOCK fill:#ce93d8,stroke:#333,color:#000
style ALOX15_4 fill:#ce93d8,stroke:#333,color:#000
style TFRC fill:#ce93d8,stroke:#333,color:#000
style ALOX15_5 fill:#ce93d8,stroke:#333,color:#000
style GPR37 fill:#ce93d8,stroke:#333,color:#000
style ALOX15_6 fill:#ce93d8,stroke:#333,color:#000
style CMKLR1 fill:#ce93d8,stroke:#333,color:#000
style ALOX15_7 fill:#ce93d8,stroke:#333,color:#000
style ALOX12 fill:#ce93d8,stroke:#333,color:#000
style ALOX15_8 fill:#ce93d8,stroke:#333,color:#000
style TREM2 fill:#ce93d8,stroke:#333,color:#000
style ALOX15_9 fill:#ce93d8,stroke:#333,color:#000
style AADC fill:#ce93d8,stroke:#333,color:#000
style ALOX15_10 fill:#ce93d8,stroke:#333,color:#000
style BCL2L1 fill:#ce93d8,stroke:#333,color:#000
style CMKLR1_11 fill:#ce93d8,stroke:#333,color:#000
style ALOX15_12 fill:#ce93d8,stroke:#333,color:#000
style ALOX12_13 fill:#ce93d8,stroke:#333,color:#000
style ALOX15_14 fill:#ce93d8,stroke:#333,color:#000
style ALOX5 fill:#ce93d8,stroke:#333,color:#000
style ALOX15_15 fill:#ce93d8,stroke:#333,color:#000
style GPR37_16 fill:#ce93d8,stroke:#333,color:#000
style ALOX15_17 fill:#ce93d8,stroke:#333,color:#000⚖️ Evidence
No linked papers recorded for this hypothesis yet.
🏥 Translation
🧬 3D Protein Structure — ALOX15
No curated PDB or AlphaFold mapping for ALOX15 yet. Search RCSB →
💉 Clinical Trials
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for ALOX15.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
🏆 Tournament
🏆 Arenas / Elo
📊 Market Indicators
💾 Resource Usage
▸Metadatasource: v1_phase_c_backfill · origin_type: debate_round_mining
| source | v1_phase_c_backfill |
| origin_type | debate_round_mining |
| _schema_version | 1 |