gene

ATRX

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATRX: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

92Connections
0Hypotheses
0Analyses
50Outgoing
29Incoming

Summary

Page for ATRX — Alpha Thalassemia/Mental Retardation Syndrome X-Linked

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🧬 Gene Info
Gene SymbolATRX
Full NameAlpha Thalassemia/Mental Retardation Syndrome X-Linked
ChromosomeXq21.1
Functionencodes a large ATP-dependent chromatin remodeler of the SWI/SNF family that plays essential roles in maintaining heterochromatin integrity, telomere stability, and genomic imprinting in the brain.
Primary Expressionneural progenitor cells and newly born neurons, consistent with its essential role in neurogenesis[@brub2005]
Molecular Weight283 kDa
Amino Acids2492 aa
Pathwaysubiquitin-proteasome
UniProt IDP46100
NCBI Gene ID546
Ensembl IDENSG00000085224
OMIM300032
GeneCardsATRX
Human Protein AtlasATRX
Associated DiseasesAD, Ms, RA, SS, cancer, glioma
KG Connections92 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: ATRX — AlphaFold P46100 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (19)

Knowledge base pages for this entity

Canonical Page

ATRX — Alpha Thalassemia/Mental Retardation Syndrome X-Linked

gene · 1312 words

H3F3B Gene — H3.3 Histone B

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setdb1-protein

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FANCM Protein

protein · 1683 words

CIC - Capicua Transcriptional Repressor

gene · 1609 words

H3F3A — H3.3 Histone A

gene · 1554 words

Pathway Diagram

graph TD
    ATRX["<b>ATRX</b>"]
    Cancer{"Cancer"}
    ATRX -->|"biomarker for"| Cancer
    Neurodegeneration{"Neurodegeneration"}
    ATRX -->|"biomarker for"| Neurodegeneration
    Ms{"Ms"}
    ATRX -->|"biomarker for"| Ms
    ATRX -->|"expressed in"| Cancer
    Tumor{"Tumor"}
    ATRX -->|"expressed in"| Tumor
    ATRX -->|"expressed in"| Ms
    Glioma{"Glioma"}
    ATRX -->|"biomarker for"| Glioma
    AKT["AKT"]
    ATRX -->|"expressed in"| AKT
    TP53["TP53"]
    ATRX -->|"expressed in"| TP53
    MLH1["MLH1"]
    ATRX -->|"expressed in"| MLH1
    Dna_Methylation(["Dna Methylation"])
    ATRX -->|"expressed in"| Dna_Methylation
    Akt(["Akt"])
    ATRX -->|"expressed in"| Akt
    IDH1["IDH1"]
    IDH1 -->|"associated with"| ATRX
    TERT["TERT"]
    TERT -->|"associated with"| ATRX
    JUN["JUN"]
    JUN -->|"biomarker for"| ATRX
    CIC["CIC"]
    CIC -->|"associated with"| ATRX
    FUBP1["FUBP1"]
    FUBP1 -->|"associated with"| ATRX
    H3F3A["H3F3A"]
    H3F3A -->|"associated with"| ATRX
    OVERVIEW["OVERVIEW"]
    OVERVIEW -->|"biomarker for"| ATRX
    BRAF["BRAF"]
    BRAF -->|"associated with"| ATRX
    MSH2["MSH2"]
    MSH2 -->|"expressed in"| ATRX
    PI3K["PI3K"]
    PI3K -->|"expressed in"| ATRX
    RB1["RB1"]
    RB1 -->|"expressed in"| ATRX
    MSH6["MSH6"]
    MSH6 -->|"expressed in"| ATRX
    style ATRX fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (63)

TargetRelationTypeStr
BRAIN TUMOURSassociated_withentity0.85
glioma prognosisassociated_withphenotype0.80
gliomasassociated_withdisease0.80
Cancerbiomarker_fordisease0.65
Neurodegenerationbiomarker_fordisease0.65

Incoming (29)

SourceRelationTypeStr
IDH1associated_withgene0.60
TERTassociated_withgene0.60
JUNbiomarker_forgene0.60
CICassociated_withgene0.60
FUBP1associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found