Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FGF9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
FGF9 is a gene implicated in neurodegeneration research. Key relationships include: biomarker for, inhibits, activates. Associated with Als, Cancer, Carcinoma. Connected to 26 entities in the SciDEX knowledge graph.
| Gene Symbol | FGF9 |
| Full Name | Fibroblast Growth Factor 9 (Glial-Activating Factor) |
| Chromosome | 13q12.11 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | Brain, Lung, Heart, Kidney, Testis |
| Molecular Weight | 23 kDa |
| Amino Acids | 208 aa |
| Exons | 3 |
| Pathways | MAPK, PI3K |
| UniProt ID | P31360 |
| NCBI Gene ID | 2254 |
| Ensembl ID | ENSG00000157184 |
| OMIM | 135501 |
| GeneCards | FGF9 |
| Human Protein Atlas | FGF9 |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis |
| Interactions | FGFR1, CX3CR1, AKT, TNF-Α, CANCER, PTEN |
| KG Connections | 31 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
FGF9["<b>FGF9</b>"]
Fibrosis{"Fibrosis"}
FGF9 -->|"biomarker for"| Fibrosis
Diabetes{"Diabetes"}
FGF9 -->|"biomarker for"| Diabetes
Als{"Als"}
FGF9 -->|"biomarker for"| Als
Ms{"Ms"}
FGF9 -->|"biomarker for"| Ms
HSPG2["HSPG2"]
FGF9 -->|"biomarker for"| HSPG2
FN1["FN1"]
FGF9 -->|"biomarker for"| FN1
Mapk(["Mapk"])
FGF9 -->|"biomarker for"| Mapk
neurodegeneration["neurodegeneration"]
FGF9 -->|"implicated in"| neurodegeneration
CD44["CD44"]
CD44 -->|"biomarker for"| FGF9
IGF1["IGF1"]
IGF1 -->|"biomarker for"| FGF9
EGF["EGF"]
EGF -->|"biomarker for"| FGF9
IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
IMMUNE_INFILTRATION -->|"biomarker for"| FGF9
KDR["KDR"]
KDR -->|"biomarker for"| FGF9
DIABETES_MELLITUS["DIABETES MELLITUS"]
DIABETES_MELLITUS -->|"biomarker for"| FGF9
style FGF9 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Fibrosis | biomarker_for | disease | 0.65 |
| Diabetes | biomarker_for | disease | 0.65 |
| Als | biomarker_for | disease | 0.65 |
| Ms | biomarker_for | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Prostate Cancer | inhibits | disease | 0.65 |
| Cancer | inhibits | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Carcinoma | activates | disease | 0.65 |
| HSPG2 | biomarker_for | gene | 0.60 |
| FGFR1 | inhibits | gene | 0.60 |
| CX3CR1 | inhibits | gene | 0.60 |
| AKT | inhibits | gene | 0.60 |
| FGFR1 | expressed_in | gene | 0.60 |
| FN1 | biomarker_for | gene | 0.60 |
| Mapk | biomarker_for | pathway | 0.60 |
| TNF-Α | activates | gene | 0.60 |
| CANCER | inhibits | gene | 0.60 |
| oligodendrocytes | expressed_in | cell_type | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CD44 | biomarker_for | gene | 0.60 |
| IGF1 | biomarker_for | gene | 0.60 |
| EGF | biomarker_for | gene | 0.60 |
| KDR | biomarker_for | gene | 0.60 |
| PTEN | inhibits | gene | 0.60 |
| TNF | activates | gene | 0.60 |
| FGF1 | expressed_in | gene | 0.60 |
| FGF2 | expressed_in | gene | 0.60 |
| CD200 | inhibits | gene | 0.60 |
| FGF2 | inhibits | gene | 0.60 |
| IMMUNE INFILTRATION | biomarker_for | gene | 0.60 |
| DIABETES MELLITUS | biomarker_for | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||