concept

DIMETHYL FUMARATE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DIMETHYL FUMARATE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

118Connections

0Hypotheses

0Analyses

48Outgoing

9Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	DIMETHYL FUMARATE
Key Genes/Proteins	NRF2, PINK1, TH
Related Diseases	NECROPTOSIS, MULTIPLE SCLEROSIS, INFLAMMATION, OXIDATIVE STRESS, AUTOPHAGY
Related Pathways	NRF2 PATHWAY, CGAS-STING PATHWAY

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    DIMETHYL_FUMARATE["DIMETHYL FUMARATE"]
    DIMETHYL_FUMARATE -->|"activates"| NFE2L2["NFE2L2"]
    DIMETHYL_FUMARATE -->|"treats"| Cognitive_Impairment["Cognitive Impairment"]
    DIMETHYL_FUMARATE -->|"treats"| Cognitive_Dysfunction["Cognitive Dysfunction"]
    DIMETHYL_FUMARATE -->|"modulates"| ASTROCYTES["ASTROCYTES"]
    DIMETHYL_FUMARATE -->|"inhibits"| STAT3["STAT3"]
    DIMETHYL_FUMARATE -->|"treats"| ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    DIMETHYL_FUMARATE -->|"activates"| NRF2_PATHWAY["NRF2 PATHWAY"]
    DIMETHYL_FUMARATE -->|"activates"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
    ASTROCYTES -->|"activates"| DIMETHYL_FUMARATE
    APP["APP"] -->|"activates"| DIMETHYL_FUMARATE

Outgoing (109)

Target	Relation	Type	Str
NRF2 PATHWAY	activates	pathway	0.65
CGAS-STING PATHWAY	activates	pathway	0.65
NECROPTOSIS	inhibits	phenotype	0.65
MULTIPLE SCLEROSIS	treats	disease	0.65
MULTIPLE SCLEROSIS	activates	disease	0.65
NRF2	regulates	gene	0.65
NRF2	produces	gene	0.65
INFLAMMATION	treats	phenotype	0.65
MULTIPLE SCLEROSIS	interacts_with	disease	0.65
OXIDATIVE STRESS	activates	phenotype	0.65
AUTOPHAGY	treats	phenotype	0.65
AUTOPHAGY	regulates	phenotype	0.65
MITOPHAGY	associated_with	phenotype	0.50
PINK1	associated_with	gene	0.50
TH	associated_with	gene	0.50
STING PATHWAY	associated_with	pathway	0.50
CANCER	associated_with	disease	0.50
STING	associated_with	gene	0.50
CGAS	associated_with	gene	0.50
ALZHEIMER	associated_with	disease	0.45
NRF2 PATHWAY	associated_with	pathway	0.45
ASTROCYTES	associated_with	cell_type	0.45
ASTROCYTE	associated_with	cell_type	0.45
NRF2	associated_with	gene	0.45
APP	associated_with	gene	0.45
NECROPTOSIS	associated_with	phenotype	0.45
RIPK1	associated_with	gene	0.45
RIPK3	associated_with	gene	0.45
MLKL	associated_with	gene	0.45
ACETYLCHOLINE	associated_with	phenotype	0.45
MICROGLIA	associated_with	cell_type	0.45
NEURONS	associated_with	cell_type	0.45
BASAL GANGLIA	associated_with	brain_region	0.45
MAPK PATHWAY	associated_with	pathway	0.45
NEURON	associated_with	cell_type	0.45
MAPK	associated_with	gene	0.45
OXIDATIVE STRESS	associated_with	phenotype	0.45
INFLAMMATION	associated_with	phenotype	0.45
FERROPTOSIS	associated_with	phenotype	0.45
DEMYELINATION	associated_with	phenotype	0.45
ISCHEMIA	associated_with	disease	0.45
FINGOLIMOD	associated_with	drug	0.45
AUTOPHAGY	associated_with	phenotype	0.45
APOPTOSIS	associated_with	phenotype	0.45
LAMP2	associated_with	gene	0.45
NEUROINFLAMMATION	associated_with	process	0.35
NEUROINFLAMMATION	activates	process	0.35
NRF2	activates	gene	0.35

Incoming (9)

Source	Relation	Type	Str
CGAS-STING PATHWAY	associated_with	pathway	0.50
ALZHEIMER	associated_with	disease	0.45
APP	associated_with	gene	0.45
ASTROCYTES	associated_with	cell_type	0.45
MULTIPLE SCLEROSIS	associated_with	disease	0.45
PARKINSON'S DISEASE	associated_with	disease	0.45
ALZHEIMER'S DISEASE	associated_with	disease	0.35
ASTROCYTES	activates	cell_type	0.35
APP	activates	gene	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

DIMETHYL FUMARATE

Understanding Entity Pages

Wiki Pages (20)

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

NRF2 Oxidative Stress Pathway

oxidative-stress-comparison

nlrc5-protein