gene

GLI

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GLI: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

32Connections

30Hypotheses

30Analyses

20Outgoing

12Incoming

Summary

GLI1, GLI2, GLI3 zinc finger transcription factors in Hedgehog signaling and neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	GLI
Function	The GLI gene family (GLI1, GLI2, GLI3) encodes C2H2-type zinc finger transcription factors that serve as the primary effectors of the Hedgehog (Hh) signaling pathway.
Exons	12
GeneCards	GLI
Human Protein Atlas	GLI
Associated Diseases	ALS
Known Drugs/Compounds	rapamycin, metformin
Interactions	GLI2, IL6, LAMP1, LC3B, MAP1LC3B, MTOR
KG Connections	32 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    GLI["GLI"] -->|"associated_with"| ALS["ALS"]
    GLI["GLI"] -->|"co_expressed_with"| GLI1["GLI1"]
    GLI["GLI"] -->|"co_expressed_with"| MYC["MYC"]
    BRD4["BRD4"] -->|"co_expressed_with"| GLI["GLI"]
    BECN1["BECN1"] -->|"co_expressed_with"| GLI["GLI"]
    BNIP3["BNIP3"] -->|"co_expressed_with"| GLI["GLI"]
    style GLI fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (20)

Target	Relation	Type	Str
ALS	associated_with	disease	0.60
GLI2	activates	gene	0.60
IL6	activates	gene	0.60
LAMP1	activates	gene	0.60
LC3B	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
MTOR	activates	gene	0.60
PPARA	activates	gene	0.60
PS1	activates	gene	0.60
PSEN1	activates	gene	0.60
SQSTM1	activates	gene	0.60
SYP	activates	gene	0.60
TFEB	activates	gene	0.60
TNF	activates	gene	0.60
autophagy pathway	participates_in	pathway	0.60
GLI1	activates	gene	0.60
oxidative stress response	participates_in	pathway	0.60
microglia	expressed_in	cell_type	0.55
GLI1	co_expressed_with	gene	0.50
MYC	co_expressed_with	gene	0.50

Incoming (12)

Source	Relation	Type	Str
FKBP5	activates	gene	0.60
GAPDH	activates	gene	0.60
GFAP	activates	gene	0.60
rapamycin	targets	drug	0.60
metformin	targets	drug	0.60
ATG	activates	gene	0.60
ATG7	activates	gene	0.60
BNIP3	activates	gene	0.60
BRD4	inhibits	gene	0.60
BRD4	co_expressed_with	gene	0.50
BECN1	co_expressed_with	gene	0.50
BNIP3	co_expressed_with	gene	0.50

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TREM2-Dependent Microglial Senescence Transition	0.692	neurodegeneration	Gene expression changes in aging mouse b
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro	0.662	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegen	0.639	neurodegeneration	Gene expression changes in aging mouse b
SASP-Driven Microglial Metabolic Reprogramming in Synaptic P	0.638	neurodegeneration	Senolytic therapy for age-related neurod
TREM2-Dependent Microglial Phagocytosis Acts as a Strain Sel	0.636	neurodegeneration	What are the specific molecular determin

IL-6 Trans-Signaling Blockade at the Oligodendrocyte-Microgl	0.632	neuroinflammation	How do oligodendrocytes initiate neuroin
Microglial TREM2-SYK Pathway Enhancement	0.626	neurodegeneration	Cell type vulnerability in Alzheimers Di
Prime Editing Precision Correction of APOE4 to APOE3 in Micr	0.622	neurodegeneration	CRISPR-based therapeutic approaches for
TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegene	0.612	neurodegeneration	Gene expression changes in aging mouse b
TREM2-ASM Crosstalk in Microglial Lysosomal Senescence	0.612	neurodegeneration	Gene expression changes in aging mouse b
TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegener	0.607	neurodegeneration	Gene expression changes in aging mouse b
TREM2-Microglial Clearance Enhancement as Common Mechanism f	0.604	neurodegeneration	Why do p300/CBP inhibitors reduce both A
Microglial AIM2 Inflammasome as the Primary Driver of TDP-43	0.601	neurodegeneration	What are the mechanisms by which gut mic
SIRT1-Mediated Reversal of TREM2-Dependent Microglial Senesc	0.600	neurodegeneration	Gene expression changes in aging mouse b
C3aR Blockade Disrupts the Microglial-Astrocyte Feedforward	0.596	neuroinflammation	What molecular mechanisms determine whet
TREM2-CSF1R Cross-Talk in Microglial Metabolic Reprogramming	0.589	neurodegeneration	Gene expression changes in aging mouse b
H1: TREM2 Agonism to Redirect APOE4-Enhanced Microglia from	0.588	neurodegeneration	How does APOE4's beneficial immune funct
Timed Senolytic Therapy Eliminates p16^Ink4a/p21^Cip1-Senesc	0.587	neuroinflammation	What molecular mechanisms drive the tran
TREM2-SIRT1 Metabolic Senescence Circuit in Microglial Aging	0.587	neurodegeneration	Gene expression changes in aging mouse b
TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegene	0.585	neurodegeneration	Gene expression changes in aging mouse b
TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegene	0.580	neurodegeneration	Gene expression changes in aging mouse b
TREM2-Mediated Cholesterol Dysregulation in Microglial Senes	0.574	neurodegeneration	Gene expression changes in aging mouse b
CYP46A1 Gene Therapy for Age-Related TREM2-Mediated Microgli	0.569	neurodegeneration	Lipid raft composition changes in synapt
Targeted Butyrate Supplementation for Microglial Phenotype M	0.559	neurodegeneration	What are the mechanisms by which gut mic
Senescent Microglia Resolution via Maresins-Senolytics Combi	0.552	neurodegeneration	Neuroinflammation resolution mechanisms
Vascular-Glial Interface Restoration	0.544	neurodegeneration	Cell type vulnerability in Alzheimers Di
ABCA7-TREM2 Co-Targeting for Microglial Lipid Handling	0.538	neurodegeneration	Why does the V1613M variant reduce amylo
Microglial-Mediated Tau Clearance Dysfunction via TREM2 Sign	0.533	neuroscience	Circuit-level neural dynamics in neurode
TREM2-Mediated Microglial Dysfunction Disrupts Perivascular	0.527	neuroscience	Circuit-level neural dynamics in neurode
Microglial TREM2-Complement Axis Modulation	0.527	neurodegeneration	Cell type vulnerability in Alzheimer's D

Mentioning Analyses (30)

Scientific analyses that reference this entity

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

neuroinflammation | 2026-04-15 | 1 hypotheses Top: 0.650

What is the temporal sequence of TREM2 signaling transition from protective to i

neuroimmunology | 2026-04-15 | 2 hypotheses Top: 0.674

How does SYNGAP1, a 'synaptic' protein, function in pre-synaptic radial glia cel

neurodevelopment | 2026-04-15 | 1 hypotheses Top: 0.576

What molecular mechanisms enable Gal3 to enhance tau fibrillation upon binding t

neurodegeneration | 2026-04-15 | 0 hypotheses

How does pericyte senescence mechanistically promote glioma cell growth and inva

neurodegeneration | 2026-04-14 | 0 hypotheses

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Ca [PMID:35642214]	Wang M, Pan W, Xu Y, Zhang J, Wan J, Jia	J Inflamm Res	2022	1
TREM2, microglia, and Alzheimer's disease. [PMID:33516818]	Qin Q, Teng Z, Liu C, Li Q, Yin Y, Tang	Mech Ageing Dev	2021	1
Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797]	Zhou Y, Song WM, Andhey PS, Swain A, Lev	Nat Med	2020	1
TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease. [PMID:28802038]	Ulland TK, Song WM, Huang SC, Ulrich JD,	Cell	2017	1
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Mic [PMID:28930663]	Krasemann S, Madore C, Cialic R, Baufeld	Immunity	2017	1
Modulating LRP1 Pathways in Alzheimer's Disease: Mechanistic Insights and Emergi [PMID:41772271]	Mushtaq T, Hameed H, Khan MA, Tariq U, H	Molecular neurobiology	2026	0
Macrophagic Sclerostin Loop2-ApoER2 Interaction Required by Sclerostin for Cardi [PMID:41276911]	Wang L, Tao X, Zhang N, Yang X, Jiang H	Adv Sci (Weinh)	2026	0
APOE Genotype Modulates the Relationship of Stroke With Dementia Risk: Associati [PMID:41404739]	Zhang CH, Huang LY, Feng YG, Tan CC, Tan	J Am Heart Assoc	2026	0
High- and Low-Fat Dairy Consumption and Long-Term Risk of Dementia: Evidence Fro [PMID:41406402]	Du Y, Borné Y, Samuelsson J, Glans I, Hu	Neurology	2026	0
Prime Editing of Alzheimer's Disease High-Risk APOE4 Allele by Brain-Directed Ad [PMID:41449667]	Günaydin C, Hackett NR, Wakim V, Sondhi	Hum Gene Ther	2026	0
The role of astrocytes in Alzheimer's disease: Pathophysiology, biomarkers, and [PMID:41527736]	Abedin MJ, Kastanenka KV	J Alzheimers Dis	2026	0
Endothelial TBK1 Deficiency Inhibits Endothelial-to-Mesenchymal Transition and A [PMID:41685426]	Pu Y, Dong P, He L, Huang J, Wu Y et al.	Circ Res	2026	0
Lipidome and proteome of astrocyte and microglia ApoE lipoprotein reveal differe [PMID:41692246]	Strickland MR, Wang Z, Golden LR, Wang H	J Lipid Res	2026	0
Protective mutations associated with APOE in Alzheimer's disease. [PMID:41703264]	Ma Y, Li Y, Wu G, Liu L, Tian M et al.	Mol Psychiatry	2026	0
HTRA1 and Brain Disorders: A Balancing Act Across Neurodegeneration and Repair. [PMID:41932381]	Hjæresen S, Gramkow ET, Zhang M, Svennin	Prog Neurobiol	2026	0
Trajectories of frailty, grip strength and gait speed preceding dementia: a nest [PMID:41936045]	Wu Z, Phyo AZZ, Cribb L, Vishwanath S, O	Age Ageing	2026	0
Amyloid-related imaging abnormalities in Japanese patients with Alzheimer's dise [PMID:41936348]	Shimasaki R, Kurihara M, Bannai T, Hatan	J Prev Alzheimers Dis	2026	0
Apolipoprotein E proteotyping as a valid alternative to genotyping in clinical p [PMID:41940854]	Alcalá Ramírez Del Puerto JM, Ortega-Mad	J Alzheimers Dis	2026	0
Opposing patterns of blood-brain barrier permeability and Alzheimer's disease bi [PMID:41942760]	Bernocchi F, Bonomi CG, Poli M, Di Donna	Neurological sciences : offici	2026	0
Structural MRI phenotyping in Alzheimer's disease: Comparison of visual rating s [PMID:41943971]	Aracki-Trenkic A, Živanović M, Milošević	Biomol Biomed	2026	0

GLI

Understanding Entity Pages

Summary

Wiki Pages (20)

PTCH2 Gene

GLI1 — GLI Family Zinc Finger 1

PAK2 Protein (p21-Activated Kinase 2)

GPR161 — G Protein-Coupled Receptor 161

Hedgehog Signaling Pathway in Neurodegeneration

Hedgehog Signaling in Neurodegeneration

DCAF17 Gene - DDB1 and CUL4 Associated Factor 17

Environmental Toxins and Parkinson's Risk

GLI Gene Family

Hedgehog Signaling in Neurodegeneration

SHH — Sonic Hedgehog

DLX6 — Distal-Less Homeobox 6

DLX6 Protein

PTCH1 — Patched 1 (Hedgehog Receptor)

SUFU — Suppressor of Fused, Hedgehog Pathway Regulator

SMO — Smoothened, Frizzled Class Receptor

Hedgehog Signaling in CBS/PSP

SMARCA2 Protein (BAF155)

JAK3 Gene

FOXM1 Gene

Pathway Diagram

Outgoing (20)

Incoming (12)

Targeting Hypotheses (30)

Mentioning Analyses (30)

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

What is the temporal sequence of TREM2 signaling transition from protective to i

How does SYNGAP1, a 'synaptic' protein, function in pre-synaptic radial glia cel

What molecular mechanisms enable Gal3 to enhance tau fibrillation upon binding t

How does pericyte senescence mechanistically promote glioma cell growth and inva

What signals trigger microglia to specifically recognize and phagocytose LC axon

What molecular mechanisms drive neuron-to-glioma synapse formation in high-neura

What is the molecular mechanism by which oligodendroglial MCT1 disruption causes

What molecular mechanisms enable microglia to neutralize OxPC-mediated neurodege

How do oligodendrocytes initiate neuroinflammation in PD when microglia are trad

How does HDAC1/2 deletion specifically enhance microglial amyloid phagocytosis c

What mechanisms explain how IDH1/IDH2 mutations with reduced enzymatic activity

What are the molecular signatures that distinguish protective vs. harmful microg

Can P16INK4A expression reliably distinguish harmful from beneficial senescent m

Do P2RX7 antagonists selectively block pathogenic exosomes while preserving bene

What brain concentrations of SCFAs are achieved via oral probiotics and are they

What distinguishes truly senescent brain cells from merely dysfunctional reactiv

Can circadian interventions selectively target microglia without affecting other

Do these mechanistic hypotheses from the SEA-AD Atlas bundle explain layer-speci

Do these mechanistic hypotheses explain layer-specific synaptic vulnerability in

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

Which specific metabolic pathways in APOE4+ microglia are most therapeutically t

Why does prolonged anesthesia cause both cognitive dysfunction and anxiety throu

How does SPI1 transcriptionally regulate C1QA and C1QC expression in atheroscler

Why do systemic anti-inflammatory drugs fail in AD despite cardiovascular effica

Do different priming stimuli require distinct therapeutic approaches or share co

Can circadian interventions reverse microglial priming independent of sleep disr

How can CNS-selective HDAC/DNMT inhibitors be developed to avoid systemic toxici

What specific astrocyte-derived factors can 'erase' pathological microglial memo

How does sevoflurane-induced NF-κB activation specifically trigger complement ca

Related Papers (20)