concept

HDC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HDC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

50Connections
0Hypotheses
0Analyses
22Outgoing
28Incoming

No summary available yet. View on Wiki →

💡 Concept Info
NameHDC
SummaryComprehensive review of the histaminergic system in the brain, focusing on the tuberomammillary nucleus, histamine receptors, and their roles in neurodegeneration, sleep disorders, and cognitive function in Alzheimer's and Parkinson's disease.
Key Genes/ProteinsSOX9, MERTK, IRF1, TSC22D3, ADRA1D, MYH2
Related DiseasesSchizophrenia
Related PathwaysHistamine metabolism, Autophagy, Cell Cycle, Immune Response, Mtor

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Histaminergic System in Neurodegeneration

cell · 1934 words

Histamine

entity · 4009 words

Tuberomammillary Nucleus in Alzheimer's Disease

cell · 2796 words

Histaminergic Tuberomammillary Neurons

cell · 2097 words

Tuberomammillary Nucleus in Sleep-Wake

cell · 1814 words

Histamine Signaling Pathway in Neurodegeneration

mechanism · 1633 words

Pathway Diagram

graph TD
    HDC["HDC"]
    HDC -->|"regulates"| SOX9["SOX9"]
    HDC -->|"regulates"| MERTK["MERTK"]
    HDC -->|"regulates"| IRF1["IRF1"]
    HDC -->|"regulates"| Autophagy["Autophagy"]
    HDC -->|"regulates"| Cell_Cycle["Cell Cycle"]
    HDC -->|"regulates"| Immune_Response["Immune Response"]
    HDC -->|"regulates"| Mtor["Mtor"]
    HDC -->|"regulates"| TSC22D3["TSC22D3"]
    HRH2["HRH2"] -->|"upregulates"| HDC
    ADRA1D["ADRA1D"] -->|"regulates"| HDC
    IL6R["IL6R"] -->|"regulates"| HDC
    ADCY9["ADCY9"] -->|"regulates"| HDC
    PPP5C["PPP5C"] -->|"regulates"| HDC
    NPY1R["NPY1R"] -->|"regulates"| HDC
    DUSP1["DUSP1"] -->|"regulates"| HDC
    VPS37B["VPS37B"] -->|"regulates"| HDC

Outgoing (22)

TargetRelationTypeStr
Schizophreniabiomarker_fordisease0.85
Histamine metabolisminvolved_inpathway0.80
SOX9regulatesgene0.60
MERTKregulatesgene0.60
IRF1regulatesgene0.60

Incoming (28)

SourceRelationTypeStr
ADRA1Dregulatesgene0.60
IL6Rregulatesgene0.60
ADCY9regulatesgene0.60
PPP5Cregulatesgene0.60
NPY1Rregulatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found