Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HDC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | HDC |
| Summary | Comprehensive review of the histaminergic system in the brain, focusing on the tuberomammillary nucleus, histamine receptors, and their roles in neurodegeneration, sleep disorders, and cognitive function in Alzheimer's and Parkinson's disease. |
| Key Genes/Proteins | SOX9, MERTK, IRF1, TSC22D3, ADRA1D, MYH2 |
| Related Diseases | Schizophrenia |
| Related Pathways | Histamine metabolism, Autophagy, Cell Cycle, Immune Response, Mtor |
Knowledge base pages for this entity
graph TD
HDC["HDC"]
HDC -->|"regulates"| SOX9["SOX9"]
HDC -->|"regulates"| MERTK["MERTK"]
HDC -->|"regulates"| IRF1["IRF1"]
HDC -->|"regulates"| Autophagy["Autophagy"]
HDC -->|"regulates"| Cell_Cycle["Cell Cycle"]
HDC -->|"regulates"| Immune_Response["Immune Response"]
HDC -->|"regulates"| Mtor["Mtor"]
HDC -->|"regulates"| TSC22D3["TSC22D3"]
HRH2["HRH2"] -->|"upregulates"| HDC
ADRA1D["ADRA1D"] -->|"regulates"| HDC
IL6R["IL6R"] -->|"regulates"| HDC
ADCY9["ADCY9"] -->|"regulates"| HDC
PPP5C["PPP5C"] -->|"regulates"| HDC
NPY1R["NPY1R"] -->|"regulates"| HDC
DUSP1["DUSP1"] -->|"regulates"| HDC
VPS37B["VPS37B"] -->|"regulates"| HDC| Target | Relation | Type | Str |
|---|---|---|---|
| Schizophrenia | biomarker_for | disease | 0.85 |
| Histamine metabolism | involved_in | pathway | 0.80 |
| SOX9 | regulates | gene | 0.60 |
| MERTK | regulates | gene | 0.60 |
| IRF1 | regulates | gene | 0.60 |
| Autophagy | regulates | pathway | 0.60 |
| Cell Cycle | regulates | pathway | 0.60 |
| Immune Response | regulates | pathway | 0.60 |
| Mtor | regulates | pathway | 0.60 |
| TSC22D3 | regulates | gene | 0.60 |
| ADRA1D | regulates | gene | 0.60 |
| MYH2 | regulates | gene | 0.60 |
| ADCY9 | regulates | gene | 0.60 |
| CALM2 | regulates | gene | 0.60 |
| VPS37B | regulates | gene | 0.60 |
| NDRG2 | regulates | gene | 0.60 |
| SOX2 | regulates | gene | 0.60 |
| Actin | regulates | protein | 0.60 |
| PPP5C | regulates | gene | 0.60 |
| LITAF | regulates | gene | 0.60 |
| Nfkb | regulates | protein | 0.60 |
| SNAP25 | biomarker_for | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ADRA1D | regulates | gene | 0.60 |
| IL6R | regulates | gene | 0.60 |
| ADCY9 | regulates | gene | 0.60 |
| PPP5C | regulates | gene | 0.60 |
| NPY1R | regulates | gene | 0.60 |
| DUSP1 | regulates | gene | 0.60 |
| VPS37B | regulates | gene | 0.60 |
| LITAF | regulates | gene | 0.60 |
| TSC22D3 | regulates | gene | 0.60 |
| NFKBIA | regulates | gene | 0.60 |
| SESN1 | regulates | gene | 0.60 |
| PDK4 | regulates | gene | 0.60 |
| AUTOPHAGY | regulates | gene | 0.60 |
| MYH2 | regulates | gene | 0.60 |
| CDKN1A | regulates | gene | 0.60 |
| JUN | regulates | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| NDRG2 | regulates | gene | 0.60 |
| CALM2 | regulates | gene | 0.60 |
| MTORC1 | regulates | gene | 0.60 |
| CCND1 | regulates | gene | 0.60 |
| GENES | regulates | gene | 0.60 |
| SOX2 | regulates | gene | 0.60 |
| MERTK | regulates | gene | 0.60 |
| SOX9 | regulates | gene | 0.60 |
| CD40LG | biomarker_for | gene | 0.60 |
| CX3CR1 | biomarker_for | gene | 0.60 |
| FUCA1 | biomarker_for | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||