Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LITAF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Gene page for LITAF encoding a lysosomal protein involved in peripheral neuropathy and inflammation
| Gene Symbol | LITAF |
| Full Name | Lipopolysaccharide-Induced Tumor Necrosis Factor Factor |
| Aliases | SIMPLE, CMT1C |
| Chromosome | 16p13.13 |
| Function | The protein contains several functional domains |
| Subcellular Localization | the lysosomal membrane and late endosome compartments. The protein contains several functional domains: |
| Molecular Weight | 17 kDa |
| Amino Acids | 161 aa |
| Pathways | Autophagy, Cell Cycle, Immune Response, Mtor |
| UniProt ID | Q9Y5K2 |
| NCBI Gene ID | 10868 |
| Ensembl ID | ENSG00000106789 |
| OMIM | 604577 |
| GeneCards | LITAF |
| Human Protein Atlas | LITAF |
| Associated Diseases | ALS, Alzheimer's disease, frontotemporal dementia |
| Interactions | SOX2, IRF1, SOX9, NFKBIA, JUN, Nfkb |
| KG Connections | 75 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
LITAF["<b>LITAF</b>"]
Ms{"Ms"}
LITAF -->|"activates"| Ms
Tumor{"Tumor"}
LITAF -->|"activates"| Tumor
Atherosclerosis{"Atherosclerosis"}
LITAF -->|"activates"| Atherosclerosis
TNF__["TNF-Alpha"]
LITAF -->|"activates"| TNF__
Mapk(["Mapk"])
LITAF -->|"activates"| Mapk
Necroptosis(["Necroptosis"])
LITAF -->|"activates"| Necroptosis
neurodegeneration["neurodegeneration"]
LITAF -->|"implicated in"| neurodegeneration
VEGF["VEGF"]
VEGF -->|"activates"| LITAF
IL18["IL18"]
IL18 -->|"activates"| LITAF
TNF["TNF"]
TNF -->|"activates"| LITAF
P38["P38"]
P38 -->|"activates"| LITAF
style LITAF fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Ms | activates | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Atherosclerosis | activates | disease | 0.65 |
| IL6R | regulates | gene | 0.60 |
| MERTK | regulates | gene | 0.60 |
| DUSP1 | regulates | gene | 0.60 |
| ADCY9 | regulates | gene | 0.60 |
| SOX2 | activates | gene | 0.60 |
| CDKN1A | regulates | gene | 0.60 |
| SESN1 | regulates | gene | 0.60 |
| IRF1 | activates | gene | 0.60 |
| NDRG2 | regulates | gene | 0.60 |
| SOX9 | activates | gene | 0.60 |
| MYH2 | regulates | gene | 0.60 |
| VPS37B | regulates | gene | 0.60 |
| NFKBIA | activates | gene | 0.60 |
| CALM2 | regulates | gene | 0.60 |
| NPY1R | regulates | gene | 0.60 |
| PDK4 | regulates | gene | 0.60 |
| JUN | activates | gene | 0.60 |
| ADRA1D | regulates | gene | 0.60 |
| Nfkb | activates | protein | 0.60 |
| OPTN | associated_with | gene | 0.60 |
| POLG | associated_with | gene | 0.60 |
| TBK1 | associated_with | gene | 0.60 |
| TNF-Α | activates | gene | 0.60 |
| Mapk | activates | pathway | 0.60 |
| Necroptosis | activates | pathway | 0.60 |
| CCND1 | regulates | gene | 0.60 |
| AUTOPHAGY | regulates | gene | 0.60 |
| MTORC1 | regulates | gene | 0.60 |
| TSC22D3 | regulates | gene | 0.60 |
| Autophagy | regulates | pathway | 0.60 |
| Mtor | regulates | pathway | 0.60 |
| Immune Response | regulates | pathway | 0.60 |
| AND | activates | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| HDC | regulates | gene | 0.60 |
| Cell Cycle | regulates | pathway | 0.60 |
| Actin | regulates | protein | 0.60 |
| ALS | associated_with | disease | 0.60 |
| Alzheimer's disease | associated_with | disease | 0.60 |
| frontotemporal dementia | associated_with | disease | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| VEGF | activates | gene | 0.60 |
| IL18 | activates | gene | 0.60 |
| TNF | activates | gene | 0.60 |
| P38 | activates | gene | 0.60 |
| PPP5C | regulates | gene | 0.60 |
| JUN | activates | gene | 0.60 |
| ADRA1D | regulates | gene | 0.60 |
| PDK4 | regulates | gene | 0.60 |
| IL6R | regulates | gene | 0.60 |
| ADCY9 | regulates | gene | 0.60 |
| NPY1R | regulates | gene | 0.60 |
| DUSP1 | regulates | gene | 0.60 |
| VPS37B | regulates | gene | 0.60 |
| MERTK | regulates | gene | 0.60 |
| CALM2 | regulates | gene | 0.60 |
| SOX9 | activates | gene | 0.60 |
| CDKN1A | regulates | gene | 0.60 |
| SESN1 | regulates | gene | 0.60 |
| MYH2 | regulates | gene | 0.60 |
| NDRG2 | regulates | gene | 0.60 |
| ALS4 | associated_with | gene | 0.60 |
| APP | associated_with | gene | 0.60 |
| CAPN1 | associated_with | gene | 0.60 |
| CCND1 | regulates | gene | 0.60 |
| MTORC1 | regulates | gene | 0.60 |
| AUTOPHAGY | regulates | gene | 0.60 |
| TSC22D3 | regulates | gene | 0.60 |
| HDC | regulates | gene | 0.60 |
| IRF1 | activates | gene | 0.50 |
| SOX2 | activates | gene | 0.50 |
| NFKBIA | activates | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||