gene

LITAF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LITAF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

75Connections
0Hypotheses
0Analyses
44Outgoing
31Incoming

Summary

Gene page for LITAF encoding a lysosomal protein involved in peripheral neuropathy and inflammation

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🧬 Gene Info
Gene SymbolLITAF
Full NameLipopolysaccharide-Induced Tumor Necrosis Factor Factor
AliasesSIMPLE, CMT1C
Chromosome16p13.13
FunctionThe protein contains several functional domains
Subcellular Localizationthe lysosomal membrane and late endosome compartments. The protein contains several functional domains:
Molecular Weight17 kDa
Amino Acids161 aa
PathwaysAutophagy, Cell Cycle, Immune Response, Mtor
UniProt IDQ9Y5K2
NCBI Gene ID10868
Ensembl IDENSG00000106789
OMIM604577
GeneCardsLITAF
Human Protein AtlasLITAF
Associated DiseasesALS, Alzheimer's disease, frontotemporal dementia
InteractionsSOX2, IRF1, SOX9, NFKBIA, JUN, Nfkb
KG Connections75 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: LITAF — AlphaFold Q9Y5K2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

LITAF — Lipopolysaccharide-Induced Tumor Necrosis Factor Factor

gene · 1116 words

Charcot-Marie-Tooth Disease

disease · 2858 words

NPY1R Gene

gene · 1930 words

Neural Crest-Derived Glia

cell · 1832 words

ADCY9 Gene

gene · 1241 words

PPP5C Protein

protein · 773 words

Pathway Diagram

graph TD
    LITAF["<b>LITAF</b>"]
    Ms{"Ms"}
    LITAF -->|"activates"| Ms
    Tumor{"Tumor"}
    LITAF -->|"activates"| Tumor
    Atherosclerosis{"Atherosclerosis"}
    LITAF -->|"activates"| Atherosclerosis
    TNF__["TNF-Alpha"]
    LITAF -->|"activates"| TNF__
    Mapk(["Mapk"])
    LITAF -->|"activates"| Mapk
    Necroptosis(["Necroptosis"])
    LITAF -->|"activates"| Necroptosis
    neurodegeneration["neurodegeneration"]
    LITAF -->|"implicated in"| neurodegeneration
    VEGF["VEGF"]
    VEGF -->|"activates"| LITAF
    IL18["IL18"]
    IL18 -->|"activates"| LITAF
    TNF["TNF"]
    TNF -->|"activates"| LITAF
    P38["P38"]
    P38 -->|"activates"| LITAF
    style LITAF fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (44)

TargetRelationTypeStr
Msactivatesdisease0.65
Tumoractivatesdisease0.65
Atherosclerosisactivatesdisease0.65
IL6Rregulatesgene0.60
MERTKregulatesgene0.60

Incoming (31)

SourceRelationTypeStr
VEGFactivatesgene0.60
IL18activatesgene0.60
TNFactivatesgene0.60
P38activatesgene0.60
PPP5Cregulatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found