Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NPY1R: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Neuropeptide Y Receptor Y1 - GPCR implicated in feeding, mood, epilepsy, and Alzheimer's disease
| Gene Symbol | NPY1R |
| Aliases | Neuropeptide Y Receptor Y1 |
| Function | is a Class A rhodopsin-family GPCR that plays critical roles in regulating feeding behavior, energy homeostasis, emotional responses, synaptic plasticity, and seizure threshold [1](https://pubmed. |
| Primary Expression | brain regions involved in energy homeostasis, emotional processing, and memory: |
| Amino Acids | 384 aa |
| Pathways | MAPK pathway |
| Ensembl ID | ENSG00000118322 |
| GeneCards | NPY1R |
| Human Protein Atlas | NPY1R |
| Associated Diseases | ALS, Asthma |
| Interactions | NPY, INFLAMMATION, Albumin |
| KG Connections | 101 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
NPY1R["<b>NPY1R</b>"]
Als{"Als"}
NPY1R -->|"associated with"| Als
Ms{"Ms"}
NPY1R -->|"contributes to"| Ms
Inflammation{"Inflammation"}
NPY1R -->|"activates"| Inflammation
NPY["NPY"]
NPY1R -->|"activates"| NPY
BDNF["BDNF"]
NPY1R -->|"contributes to"| BDNF
STAT6["STAT6"]
NPY1R -->|"associated with"| STAT6
JAK["JAK"]
NPY1R -->|"associated with"| JAK
AND["AND"]
NPY1R -->|"contributes to"| AND
CYTOKINES["CYTOKINES"]
NPY1R -->|"contributes to"| CYTOKINES
INFLAMMATION["INFLAMMATION"]
NPY1R -->|"activates"| INFLAMMATION
neurodegeneration["neurodegeneration"]
NPY1R -->|"implicated in"| neurodegeneration
JAK -->|"associated with"| NPY1R
CYTOKINES -->|"contributes to"| NPY1R
INFLAMMATION -->|"activates"| NPY1R
NPY -->|"activates"| NPY1R
style NPY1R fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| nociceptor excitability | inhibits | phenotype | 0.80 |
| Als | associated_with | disease | 0.65 |
| Ms | contributes_to | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| Asthma | associated_with | disease | 0.65 |
| Als | causes | disease | 0.65 |
| ALS | causes | disease | 0.65 |
| NPY | activates | gene | 0.60 |
| BDNF | contributes_to | gene | 0.60 |
| STAT6 | associated_with | gene | 0.60 |
| STAT6 | causes | gene | 0.60 |
| DUSP1 | regulates | gene | 0.60 |
| VPS37B | regulates | gene | 0.60 |
| LITAF | regulates | gene | 0.60 |
| NFKBIA | regulates | gene | 0.60 |
| SESN1 | regulates | gene | 0.60 |
| PDK4 | regulates | gene | 0.60 |
| MYH2 | regulates | gene | 0.60 |
| CDKN1A | regulates | gene | 0.60 |
| JUN | regulates | gene | 0.60 |
| NDRG2 | regulates | gene | 0.60 |
| CALM2 | regulates | gene | 0.60 |
| SOX2 | regulates | gene | 0.60 |
| SOX9 | regulates | gene | 0.60 |
| MERTK | regulates | gene | 0.60 |
| IRF1 | regulates | gene | 0.60 |
| BDNF | causes | gene | 0.60 |
| IL6R | regulates | gene | 0.60 |
| ADRA1D | regulates | gene | 0.60 |
| PPP5C | regulates | gene | 0.60 |
| ADCY9 | regulates | gene | 0.60 |
| Nfkb | regulates | protein | 0.60 |
| JAK | associated_with | gene | 0.60 |
| CYTOKINES | contributes_to | gene | 0.60 |
| INFLAMMATION | activates | gene | 0.60 |
| JAK | causes | gene | 0.60 |
| Autophagy | regulates | pathway | 0.60 |
| Mtor | regulates | pathway | 0.60 |
| Immune Response | regulates | pathway | 0.60 |
| IL-13 | causes | gene | 0.60 |
| CYTOKINES | causes | gene | 0.60 |
| Neuron | activates | cell_type | 0.60 |
| TSC22D3 | regulates | gene | 0.60 |
| AUTOPHAGY | regulates | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| MTORC1 | regulates | gene | 0.60 |
| CCND1 | regulates | gene | 0.60 |
| GENES | regulates | gene | 0.60 |
| HDC | regulates | gene | 0.60 |
| Cell Cycle | regulates | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NPY | activates | gene | 0.60 |
| BDNF | causes | gene | 0.60 |
| PPP5C | regulates | gene | 0.60 |
| JUN | regulates | gene | 0.60 |
| ADRA1D | regulates | gene | 0.60 |
| PDK4 | regulates | gene | 0.60 |
| LITAF | regulates | gene | 0.60 |
| IL6R | regulates | gene | 0.60 |
| MERTK | regulates | gene | 0.60 |
| DUSP1 | regulates | gene | 0.60 |
| ADCY9 | regulates | gene | 0.60 |
| SOX2 | regulates | gene | 0.60 |
| CDKN1A | regulates | gene | 0.60 |
| SESN1 | regulates | gene | 0.60 |
| IRF1 | regulates | gene | 0.60 |
| NDRG2 | regulates | gene | 0.60 |
| SOX9 | regulates | gene | 0.60 |
| MYH2 | regulates | gene | 0.60 |
| VPS37B | regulates | gene | 0.60 |
| NFKBIA | regulates | gene | 0.60 |
| CALM2 | regulates | gene | 0.60 |
| STAT6 | causes | gene | 0.60 |
| JAK | associated_with | gene | 0.60 |
| CYTOKINES | contributes_to | gene | 0.60 |
| INFLAMMATION | activates | gene | 0.60 |
| CYTOKINES | causes | gene | 0.60 |
| CCND1 | regulates | gene | 0.60 |
| AUTOPHAGY | regulates | gene | 0.60 |
| MTORC1 | regulates | gene | 0.60 |
| TSC22D3 | regulates | gene | 0.60 |
| IL-1 | causes | gene | 0.60 |
| RNA | causes | gene | 0.60 |
| AND | causes | gene | 0.60 |
| IL-13 | causes | gene | 0.60 |
| adcy9 | regulates | gene | 0.50 |
| adra1d | regulates | gene | 0.50 |
| Autophagy | regulates | process | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||