gene

NPY1R

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NPY1R: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

106Connections
0Hypotheses
0Analyses
50Outgoing
37Incoming

Summary

Neuropeptide Y Receptor Y1 - GPCR implicated in feeding, mood, epilepsy, and Alzheimer's disease

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🧬 Gene Info
Gene SymbolNPY1R
AliasesNeuropeptide Y Receptor Y1
Functionis a Class A rhodopsin-family GPCR that plays critical roles in regulating feeding behavior, energy homeostasis, emotional responses, synaptic plasticity, and seizure threshold [1](https://pubmed.
Primary Expressionbrain regions involved in energy homeostasis, emotional processing, and memory:
Amino Acids384 aa
PathwaysMAPK pathway
Ensembl IDENSG00000118322
GeneCardsNPY1R
Human Protein AtlasNPY1R
Associated DiseasesALS, Asthma
InteractionsNPY, INFLAMMATION, Albumin
KG Connections101 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

NPY1R Gene

gene · 1930 words

Neuropeptide Y (NPY) Neurons

cell · 2977 words

Neuropeptide Y Signaling in Neurodegeneration

mechanism · 2574 words

NPY5R — Neuropeptide Y Receptor Y5

gene · 2471 words

Npy Y1 Receptor Neurons

cell_type · 2029 words

MYH2 Gene

gene · 1549 words

Pathway Diagram

graph TD
    NPY1R["<b>NPY1R</b>"]
    Als{"Als"}
    NPY1R -->|"associated with"| Als
    Ms{"Ms"}
    NPY1R -->|"contributes to"| Ms
    Inflammation{"Inflammation"}
    NPY1R -->|"activates"| Inflammation
    NPY["NPY"]
    NPY1R -->|"activates"| NPY
    BDNF["BDNF"]
    NPY1R -->|"contributes to"| BDNF
    STAT6["STAT6"]
    NPY1R -->|"associated with"| STAT6
    JAK["JAK"]
    NPY1R -->|"associated with"| JAK
    AND["AND"]
    NPY1R -->|"contributes to"| AND
    CYTOKINES["CYTOKINES"]
    NPY1R -->|"contributes to"| CYTOKINES
    INFLAMMATION["INFLAMMATION"]
    NPY1R -->|"activates"| INFLAMMATION
    neurodegeneration["neurodegeneration"]
    NPY1R -->|"implicated in"| neurodegeneration
    JAK -->|"associated with"| NPY1R
    CYTOKINES -->|"contributes to"| NPY1R
    INFLAMMATION -->|"activates"| NPY1R
    NPY -->|"activates"| NPY1R
    style NPY1R fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (65)

TargetRelationTypeStr
nociceptor excitabilityinhibitsphenotype0.80
Alsassociated_withdisease0.65
Mscontributes_todisease0.65
Inflammationactivatesdisease0.65
Asthmaassociated_withdisease0.65

Incoming (41)

SourceRelationTypeStr
NPYactivatesgene0.60
BDNFcausesgene0.60
PPP5Cregulatesgene0.60
JUNregulatesgene0.60
ADRA1Dregulatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found