gene

MYH2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MYH2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

55Connections
0Hypotheses
0Analyses
28Outgoing
27Incoming

Summary

Myosin Heavy Chain 2 - fast-twitch skeletal muscle myosin, mutations cause myosin storage myopathy and congenital myopathies with ophthalmoplegia

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🧬 Gene Info
Gene SymbolMYH2
AliasesMyosin Heavy Chain 2
FunctionMYH2 encodes the myosin heavy chain 2 (MyHC-IIa) protein, which is a member of the class II conventional myosin family.
Primary Expressionfast-twitch type 2a muscle fibers, which are characterized by:
Amino Acids240 aa
PathwaysAutophagy, Cell Cycle, Immune Response, Mtor
Ensembl IDENSG00000141349
GeneCardsMYH2
Human Protein AtlasMYH2
Rapid contractionType 2a fibers contract 2-3 times faster than slow type 1 fibers
High glycolytic capacityPrimarily use glycolysis for ATP production
Intermediate fatigue resistanceMore resistant to fatigue than type 2b fibers but less than type 1
Oxidative metabolismContain more mitochondria than type 2b fibers
Skeletal muscleHighest expression in fast-twitch skeletal muscle
Extraocular musclesHighly expressed in muscles controlling eye movements
Associated Diseasesneurodegeneration
KG Connections55 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (11)

Knowledge base pages for this entity

Canonical Page

MYH2 Gene

gene · 1549 words

MYH8 (Myosin Heavy Chain 8)

gene · 2361 words

Tuberomammillary Nucleus in Sleep-Wake

cell · 1814 words

ADCY9 Gene

gene · 1241 words

LITAF — Lipopolysaccharide-Induced Tumor Necrosis Factor Factor

gene · 1116 words

CALM2 Gene

gene · 805 words

Pathway Diagram

graph TD
    MYH2["MYH2"]
    VPS37B["VPS37B"]
    MTORC1["MTORC1"]
    NFKBIA["NFKBIA"]
    CALM2["CALM2"]
    TSC22D3["TSC22D3"]
    NPY1R["NPY1R"]
    Autophagy["Autophagy"]
    Mtor["Mtor"]
    Immune_Response["Immune Response"]
    PPP5C["PPP5C"]
    JUN["JUN"]
    ADRA1D["ADRA1D"]
    PDK4["PDK4"]
    LITAF["LITAF"]
    IL6R["IL6R"]
    CCND1["CCND1"]
    MERTK["MERTK"]
    DUSP1["DUSP1"]
    ADCY9["ADCY9"]
    AUTOPHAGY["AUTOPHAGY"]
    MYH2 -->|"regulates"| VPS37B
    MYH2 -->|"regulates"| MTORC1
    MYH2 -->|"regulates"| NFKBIA
    MYH2 -->|"regulates"| CALM2
    MYH2 -->|"regulates"| TSC22D3
    MYH2 -->|"regulates"| NPY1R
    MYH2 -->|"regulates"| Autophagy
    MYH2 -->|"regulates"| Mtor
    MYH2 -->|"regulates"| Immune_Response
    PPP5C -->|"regulates"| MYH2
    JUN -->|"regulates"| MYH2
    ADRA1D -->|"regulates"| MYH2
    PDK4 -->|"regulates"| MYH2
    LITAF -->|"regulates"| MYH2
    IL6R -->|"regulates"| MYH2
    CCND1 -->|"regulates"| MYH2
    MERTK -->|"regulates"| MYH2
    DUSP1 -->|"regulates"| MYH2
    ADCY9 -->|"regulates"| MYH2
    AUTOPHAGY -->|"regulates"| MYH2
    style MYH2 fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (28)

TargetRelationTypeStr
VPS37Bregulatesgene0.60
NFKBIAregulatesgene0.60
CALM2regulatesgene0.60
NPY1Rregulatesgene0.60
CDKN1Aregulatesgene0.60

Incoming (27)

SourceRelationTypeStr
PPP5Cregulatesgene0.60
JUNregulatesgene0.60
ADRA1Dregulatesgene0.60
PDK4regulatesgene0.60
LITAFregulatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found