Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MYH2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Myosin Heavy Chain 2 - fast-twitch skeletal muscle myosin, mutations cause myosin storage myopathy and congenital myopathies with ophthalmoplegia
| Gene Symbol | MYH2 |
| Aliases | Myosin Heavy Chain 2 |
| Function | MYH2 encodes the myosin heavy chain 2 (MyHC-IIa) protein, which is a member of the class II conventional myosin family. |
| Primary Expression | fast-twitch type 2a muscle fibers, which are characterized by: |
| Amino Acids | 240 aa |
| Pathways | Autophagy, Cell Cycle, Immune Response, Mtor |
| Ensembl ID | ENSG00000141349 |
| GeneCards | MYH2 |
| Human Protein Atlas | MYH2 |
| Rapid contraction | Type 2a fibers contract 2-3 times faster than slow type 1 fibers |
| High glycolytic capacity | Primarily use glycolysis for ATP production |
| Intermediate fatigue resistance | More resistant to fatigue than type 2b fibers but less than type 1 |
| Oxidative metabolism | Contain more mitochondria than type 2b fibers |
| Skeletal muscle | Highest expression in fast-twitch skeletal muscle |
| Extraocular muscles | Highly expressed in muscles controlling eye movements |
| Associated Diseases | neurodegeneration |
| KG Connections | 55 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
MYH2["MYH2"]
VPS37B["VPS37B"]
MTORC1["MTORC1"]
NFKBIA["NFKBIA"]
CALM2["CALM2"]
TSC22D3["TSC22D3"]
NPY1R["NPY1R"]
Autophagy["Autophagy"]
Mtor["Mtor"]
Immune_Response["Immune Response"]
PPP5C["PPP5C"]
JUN["JUN"]
ADRA1D["ADRA1D"]
PDK4["PDK4"]
LITAF["LITAF"]
IL6R["IL6R"]
CCND1["CCND1"]
MERTK["MERTK"]
DUSP1["DUSP1"]
ADCY9["ADCY9"]
AUTOPHAGY["AUTOPHAGY"]
MYH2 -->|"regulates"| VPS37B
MYH2 -->|"regulates"| MTORC1
MYH2 -->|"regulates"| NFKBIA
MYH2 -->|"regulates"| CALM2
MYH2 -->|"regulates"| TSC22D3
MYH2 -->|"regulates"| NPY1R
MYH2 -->|"regulates"| Autophagy
MYH2 -->|"regulates"| Mtor
MYH2 -->|"regulates"| Immune_Response
PPP5C -->|"regulates"| MYH2
JUN -->|"regulates"| MYH2
ADRA1D -->|"regulates"| MYH2
PDK4 -->|"regulates"| MYH2
LITAF -->|"regulates"| MYH2
IL6R -->|"regulates"| MYH2
CCND1 -->|"regulates"| MYH2
MERTK -->|"regulates"| MYH2
DUSP1 -->|"regulates"| MYH2
ADCY9 -->|"regulates"| MYH2
AUTOPHAGY -->|"regulates"| MYH2
style MYH2 fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px| Target | Relation | Type | Str |
|---|---|---|---|
| VPS37B | regulates | gene | 0.60 |
| NFKBIA | regulates | gene | 0.60 |
| CALM2 | regulates | gene | 0.60 |
| NPY1R | regulates | gene | 0.60 |
| CDKN1A | regulates | gene | 0.60 |
| JUN | regulates | gene | 0.60 |
| NDRG2 | regulates | gene | 0.60 |
| SOX2 | regulates | gene | 0.60 |
| SOX9 | regulates | gene | 0.60 |
| MERTK | regulates | gene | 0.60 |
| IRF1 | regulates | gene | 0.60 |
| ADCY9 | regulates | gene | 0.60 |
| ADRA1D | regulates | gene | 0.60 |
| PPP5C | regulates | gene | 0.60 |
| LITAF | regulates | gene | 0.60 |
| Nfkb | regulates | protein | 0.60 |
| MTORC1 | regulates | gene | 0.60 |
| TSC22D3 | regulates | gene | 0.60 |
| Autophagy | regulates | pathway | 0.60 |
| Mtor | regulates | pathway | 0.60 |
| Immune Response | regulates | pathway | 0.60 |
| AND | regulates | gene | 0.60 |
| CCND1 | regulates | gene | 0.60 |
| GENES | regulates | gene | 0.60 |
| HDC | regulates | gene | 0.60 |
| Cell Cycle | regulates | pathway | 0.60 |
| Actin | regulates | protein | 0.60 |
| IMMUNE RESPONSE | regulates | pathway | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PPP5C | regulates | gene | 0.60 |
| JUN | regulates | gene | 0.60 |
| ADRA1D | regulates | gene | 0.60 |
| PDK4 | regulates | gene | 0.60 |
| LITAF | regulates | gene | 0.60 |
| IL6R | regulates | gene | 0.60 |
| MERTK | regulates | gene | 0.60 |
| DUSP1 | regulates | gene | 0.60 |
| ADCY9 | regulates | gene | 0.60 |
| SOX2 | regulates | gene | 0.60 |
| CDKN1A | regulates | gene | 0.60 |
| SESN1 | regulates | gene | 0.60 |
| IRF1 | regulates | gene | 0.60 |
| NDRG2 | regulates | gene | 0.60 |
| SOX9 | regulates | gene | 0.60 |
| NPY1R | regulates | gene | 0.60 |
| VPS37B | regulates | gene | 0.60 |
| NFKBIA | regulates | gene | 0.60 |
| CALM2 | regulates | gene | 0.60 |
| CCND1 | regulates | gene | 0.60 |
| AUTOPHAGY | regulates | gene | 0.60 |
| TSC22D3 | regulates | gene | 0.60 |
| HDC | regulates | gene | 0.60 |
| MTORC1 | regulates | gene | 0.60 |
| adcy9 | regulates | gene | 0.50 |
| adra1d | regulates | gene | 0.50 |
| Autophagy | regulates | process | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||