VPS37B

Understanding Entity Pages

This page aggregates everything SciDEX knows about VPS37B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

VPS37B encodes ESCRT-I subunit involved in endosomal trafficking, linked to Parkinson's disease and lysosomal disorders.

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graph TD
    VPS37B["VPS37B"]
    CHMP4B["CHMP4B"]
    MTORC1["MTORC1"]
    NFKBIA["NFKBIA"]
    CALM2["CALM2"]
    TSC22D3["TSC22D3"]
    NPY1R["NPY1R"]
    Autophagy["Autophagy"]
    Mtor["Mtor"]
    Immune_Response["Immune Response"]
    DNAJB6["DNAJB6"]
    PPP5C["PPP5C"]
    JUN["JUN"]
    ADRA1D["ADRA1D"]
    PDK4["PDK4"]
    LITAF["LITAF"]
    IL6R["IL6R"]
    CCND1["CCND1"]
    MERTK["MERTK"]
    DUSP1["DUSP1"]
    ADCY9["ADCY9"]
    VPS37B -.-|"associated"| CHMP4B
    VPS37B -->|"regulates"| MTORC1
    VPS37B -->|"regulates"| NFKBIA
    VPS37B -->|"regulates"| CALM2
    VPS37B -->|"regulates"| TSC22D3
    VPS37B -->|"regulates"| NPY1R
    VPS37B -->|"regulates"| Autophagy
    VPS37B -->|"regulates"| Mtor
    VPS37B -->|"regulates"| Immune_Response
    DNAJB6 -.-|"associated"| VPS37B
    PPP5C -->|"regulates"| VPS37B
    JUN -->|"regulates"| VPS37B
    ADRA1D -->|"regulates"| VPS37B
    PDK4 -->|"regulates"| VPS37B
    LITAF -->|"regulates"| VPS37B
    IL6R -->|"regulates"| VPS37B
    CCND1 -->|"regulates"| VPS37B
    MERTK -->|"regulates"| VPS37B
    DUSP1 -->|"regulates"| VPS37B
    ADCY9 -->|"regulates"| VPS37B
    style VPS37B fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px