Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CALM2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | CALM2 |
| Protein Family | EF-hand calcium-binding protein family |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Subcellular Localization | Cytoplasm, Nucleus |
| Amino Acids | 148 aa |
| Exons | 6 exons spanning approximately 3.5 kb |
| Pathways | Autophagy, Cell Cycle, Immune Response, Mtor |
| Ensembl ID | ENSG00000101444 |
| GeneCards | CALM2 |
| Human Protein Atlas | CALM2 |
| Promoter | Contains multiple transcription factor binding sites |
| Regulatory Elements | Responsive to calcium, cAMP, and cellular stress |
| Associated Diseases | neurodegeneration |
| KG Connections | 59 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CALM2["CALM2"]
TSC22D3["TSC22D3"]
NPY1R["NPY1R"]
Autophagy["Autophagy"]
Mtor["Mtor"]
Immune_Response["Immune Response"]
PPP5C["PPP5C"]
JUN["JUN"]
ADRA1D["ADRA1D"]
PDK4["PDK4"]
LITAF["LITAF"]
IL6R["IL6R"]
CCND1["CCND1"]
MERTK["MERTK"]
DUSP1["DUSP1"]
ADCY9["ADCY9"]
AUTOPHAGY["AUTOPHAGY"]
SOX2["SOX2"]
CDKN1A["CDKN1A"]
SESN1["SESN1"]
IRF1["IRF1"]
CALM2 -->|"regulates"| TSC22D3
CALM2 -->|"regulates"| NPY1R
CALM2 -->|"regulates"| Autophagy
CALM2 -->|"regulates"| Mtor
CALM2 -->|"regulates"| Immune_Response
PPP5C -->|"regulates"| CALM2
JUN -->|"regulates"| CALM2
ADRA1D -->|"regulates"| CALM2
PDK4 -->|"regulates"| CALM2
LITAF -->|"regulates"| CALM2
IL6R -->|"regulates"| CALM2
CCND1 -->|"regulates"| CALM2
MERTK -->|"regulates"| CALM2
DUSP1 -->|"regulates"| CALM2
ADCY9 -->|"regulates"| CALM2
AUTOPHAGY -->|"regulates"| CALM2
SOX2 -->|"regulates"| CALM2
CDKN1A -->|"regulates"| CALM2
SESN1 -->|"regulates"| CALM2
IRF1 -->|"regulates"| CALM2
style CALM2 fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px| Target | Relation | Type | Str |
|---|---|---|---|
| NPY1R | regulates | gene | 0.60 |
| SOX2 | regulates | gene | 0.60 |
| SOX9 | regulates | gene | 0.60 |
| MERTK | regulates | gene | 0.60 |
| IRF1 | regulates | gene | 0.60 |
| NDRG2 | regulates | gene | 0.60 |
| PDK4 | regulates | gene | 0.60 |
| IL6R | regulates | gene | 0.60 |
| DUSP1 | regulates | gene | 0.60 |
| NFKBIA | regulates | gene | 0.60 |
| CDKN1A | regulates | gene | 0.60 |
| JUN | regulates | gene | 0.60 |
| SESN1 | regulates | gene | 0.60 |
| MYH2 | regulates | gene | 0.60 |
| ADRA1D | regulates | gene | 0.60 |
| PPP5C | regulates | gene | 0.60 |
| ADCY9 | regulates | gene | 0.60 |
| LITAF | regulates | gene | 0.60 |
| Nfkb | regulates | protein | 0.60 |
| TSC22D3 | regulates | gene | 0.60 |
| Autophagy | regulates | pathway | 0.60 |
| Mtor | regulates | pathway | 0.60 |
| Immune Response | regulates | pathway | 0.60 |
| MTORC1 | regulates | gene | 0.60 |
| CCND1 | regulates | gene | 0.60 |
| GENES | regulates | gene | 0.60 |
| HDC | regulates | gene | 0.60 |
| Cell Cycle | regulates | pathway | 0.60 |
| Actin | regulates | protein | 0.60 |
| VPS37B | regulates | gene | 0.50 |
| IMMUNE RESPONSE | regulates | pathway | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PPP5C | regulates | gene | 0.60 |
| JUN | regulates | gene | 0.60 |
| ADRA1D | regulates | gene | 0.60 |
| PDK4 | regulates | gene | 0.60 |
| LITAF | regulates | gene | 0.60 |
| IL6R | regulates | gene | 0.60 |
| MERTK | regulates | gene | 0.60 |
| DUSP1 | regulates | gene | 0.60 |
| ADCY9 | regulates | gene | 0.60 |
| SOX2 | regulates | gene | 0.60 |
| CDKN1A | regulates | gene | 0.60 |
| SESN1 | regulates | gene | 0.60 |
| IRF1 | regulates | gene | 0.60 |
| NDRG2 | regulates | gene | 0.60 |
| SOX9 | regulates | gene | 0.60 |
| MYH2 | regulates | gene | 0.60 |
| VPS37B | regulates | gene | 0.60 |
| NFKBIA | regulates | gene | 0.60 |
| NPY1R | regulates | gene | 0.60 |
| CCND1 | regulates | gene | 0.60 |
| AUTOPHAGY | regulates | gene | 0.60 |
| MTORC1 | regulates | gene | 0.60 |
| TSC22D3 | regulates | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| HDC | regulates | gene | 0.60 |
| adcy9 | regulates | gene | 0.50 |
| adra1d | regulates | gene | 0.50 |
| Autophagy | regulates | process | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||