gene

CALM2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CALM2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

59Connections
0Hypotheses
0Analyses
31Outgoing
28Incoming

Summary

Page for CALM2 Gene

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🧬 Gene Info
Gene SymbolCALM2
Protein FamilyEF-hand calcium-binding protein family
Functionis an important component in the neurobiology of neurodegenerative diseases.
Subcellular LocalizationCytoplasm, Nucleus
Amino Acids148 aa
Exons6 exons spanning approximately 3.5 kb
PathwaysAutophagy, Cell Cycle, Immune Response, Mtor
Ensembl IDENSG00000101444
GeneCardsCALM2
Human Protein AtlasCALM2
PromoterContains multiple transcription factor binding sites
Regulatory ElementsResponsive to calcium, cAMP, and cellular stress
Associated Diseasesneurodegeneration
KG Connections59 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

CALM2 Gene

gene · 805 words

CALM4 — Calmodulin 4

gene · 3697 words

Calcium Homeostasis in Neurodegeneration

mechanism · 3102 words

ER-Golgi Secretory Pathway Dysfunction Hypothesis in Parkinson's Disease

hypothesis · 2790 words

Selective Neuronal Vulnerability in Corticobasal Syndrome

mechanism · 1970 words

Tuberomammillary Nucleus in Sleep-Wake

cell · 1814 words

Pathway Diagram

graph TD
    CALM2["CALM2"]
    TSC22D3["TSC22D3"]
    NPY1R["NPY1R"]
    Autophagy["Autophagy"]
    Mtor["Mtor"]
    Immune_Response["Immune Response"]
    PPP5C["PPP5C"]
    JUN["JUN"]
    ADRA1D["ADRA1D"]
    PDK4["PDK4"]
    LITAF["LITAF"]
    IL6R["IL6R"]
    CCND1["CCND1"]
    MERTK["MERTK"]
    DUSP1["DUSP1"]
    ADCY9["ADCY9"]
    AUTOPHAGY["AUTOPHAGY"]
    SOX2["SOX2"]
    CDKN1A["CDKN1A"]
    SESN1["SESN1"]
    IRF1["IRF1"]
    CALM2 -->|"regulates"| TSC22D3
    CALM2 -->|"regulates"| NPY1R
    CALM2 -->|"regulates"| Autophagy
    CALM2 -->|"regulates"| Mtor
    CALM2 -->|"regulates"| Immune_Response
    PPP5C -->|"regulates"| CALM2
    JUN -->|"regulates"| CALM2
    ADRA1D -->|"regulates"| CALM2
    PDK4 -->|"regulates"| CALM2
    LITAF -->|"regulates"| CALM2
    IL6R -->|"regulates"| CALM2
    CCND1 -->|"regulates"| CALM2
    MERTK -->|"regulates"| CALM2
    DUSP1 -->|"regulates"| CALM2
    ADCY9 -->|"regulates"| CALM2
    AUTOPHAGY -->|"regulates"| CALM2
    SOX2 -->|"regulates"| CALM2
    CDKN1A -->|"regulates"| CALM2
    SESN1 -->|"regulates"| CALM2
    IRF1 -->|"regulates"| CALM2
    style CALM2 fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (31)

TargetRelationTypeStr
NPY1Rregulatesgene0.60
SOX2regulatesgene0.60
SOX9regulatesgene0.60
MERTKregulatesgene0.60
IRF1regulatesgene0.60

Incoming (28)

SourceRelationTypeStr
PPP5Cregulatesgene0.60
JUNregulatesgene0.60
ADRA1Dregulatesgene0.60
PDK4regulatesgene0.60
LITAFregulatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found