concept

MEIS1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MEIS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

50Connections

0Hypotheses

0Analyses

32Outgoing

18Incoming

0Experiments

No summary available yet. View on Wiki →

💡 Concept Info

Name	MEIS1
Key Genes/Proteins	ELF3, PHGDH
Related Diseases	Neuroendocrine-Like Features, Cancer, Tumor, Leukemia
Related Pathways	Akt, Pi3K, Mapk, Pi3K/Akt

Wiki Pages (3)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    MEIS1["MEIS1"]
    MEIS1 -->|"regulates"| Neuroendocrine_Like_Features["Neuroendocrine-Like Features"]
    MEIS1 -->|"activates"| Cancer["Cancer"]
    MEIS1 -->|"activates"| Tumor["Tumor"]
    MEIS1 -->|"target for"| Leukemia["Leukemia"]
    MEIS1 -->|"activates"| ELF3["ELF3"]
    MEIS1 -->|"activates"| Akt["Akt"]
    ERK["ERK"] -->|"activates"| MEIS1
    GAIN["GAIN"] -->|"activates"| MEIS1
    PHGDH["PHGDH"] -->|"activates"| MEIS1
    ACAT1["ACAT1"] -->|"activates"| MEIS1
    PI3K["PI3K"] -->|"activates"| MEIS1
    ERBB2["ERBB2"] -->|"activates"| MEIS1
    AKT["AKT"] -->|"activates"| MEIS1
    ERBB3["ERBB3"] -->|"activates"| MEIS1

Outgoing (32)

Target	Relation	Type	Str
Neuroendocrine-Like Features	regulates	phenotype	0.75
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Leukemia	therapeutic_target	disease	0.65
ELF3	activates	gene	0.60
Akt	activates	pathway	0.60
Pi3K	activates	pathway	0.60
Mapk	activates	pathway	0.60
Akt	therapeutic_target	pathway	0.60
Mapk	therapeutic_target	pathway	0.60
Pi3K	therapeutic_target	pathway	0.60
Pi3K/Akt	activates	pathway	0.60
PHGDH	activates	gene	0.60
TP53	activates	gene	0.60
CANCER	activates	gene	0.60
PI3K	activates	gene	0.60
Epigenetic	therapeutic_target	pathway	0.60
Invasion	activates	pathway	0.60
Erk Signaling	activates	pathway	0.60
GAIN	activates	gene	0.60
MAPK	activates	gene	0.60
AND	activates	gene	0.60
RAS	activates	gene	0.60
ERK	activates	gene	0.60
ACAT1	activates	gene	0.60
ERBB3	activates	gene	0.60
ERBB2	activates	gene	0.60
P53	activates	protein	0.60
Rb	activates	protein	0.60
neuroendocrine_features	regulates	phenotype	0.56

Incoming (18)

Source	Relation	Type	Str
ERK	activates	gene	0.60
GAIN	activates	gene	0.60
PHGDH	activates	gene	0.60
ACAT1	activates	gene	0.60
PI3K	activates	gene	0.60
ERBB2	activates	gene	0.60
AKT	activates	gene	0.60
ERBB3	activates	gene	0.60
TP53	activates	gene	0.60
ACAT1	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60
ELF3	activates	gene	0.60
CANCER	activates	gene	0.60
RAS	activates	gene	0.60
OVERVIEW	therapeutic_target	gene	0.60
DOT1L	regulates	gene	0.60
GENES	regulates	gene	0.60
MAPK	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found