Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about adra1d: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ADRA1D |
| Full Name | Alpha-1D Adrenergic Receptor |
| Chromosome | 19p13 |
| Primary Expression | the cerebral cortex, hippocampus, thalamus, hypothalamus, and vascular smooth muscle, where it mediates diverse physiological responses |
| Molecular Weight | 60 kDa |
| Amino Acids | 560 aa |
| Exons | 2 |
| Pathways | Autophagy, IMMUNE RESPONSE |
| UniProt ID | P25100 |
| NCBI Gene ID | 146 |
| Ensembl ID | ENSG00000160040 |
| OMIM | 104221 |
| GeneCards | ADRA1D |
| Human Protein Atlas | ADRA1D |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| KG Connections | 12 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
ADRA1D["ADRA1D"]
ADRA1D -->|"regulates"| PDK4["PDK4"]
ADRA1D -->|"regulates"| LITAF["LITAF"]
ADRA1D -->|"regulates"| IL6R["IL6R"]
ADRA1D -->|"regulates"| CCND1["CCND1"]
ADRA1D -->|"regulates"| MERTK["MERTK"]
ADRA1D -->|"regulates"| DUSP1["DUSP1"]
ADRA1D -->|"regulates"| ADCY9["ADCY9"]
ADRA1D -->|"regulates"| AUTOPHAGY["AUTOPHAGY"]
PPP5C["PPP5C"] -->|"regulates"| ADRA1D
JUN["JUN"] -->|"regulates"| ADRA1D
CCND1 -->|"regulates"| ADRA1D
LITAF -->|"regulates"| ADRA1D
IL6R -->|"regulates"| ADRA1D
HDC["HDC"] -->|"regulates"| ADRA1D
TSC22D3["TSC22D3"] -->|"regulates"| ADRA1D
NPY1R["NPY1R"] -->|"regulates"| ADRA1D| Target | Relation | Type | Str |
|---|---|---|---|
| Autophagy | regulates | process | 0.50 |
| IL6R | regulates | gene | 0.50 |
| PDK4 | regulates | gene | 0.50 |
| MERTK | regulates | gene | 0.50 |
| MYH2 | regulates | gene | 0.50 |
| NPY1R | regulates | gene | 0.50 |
| CALM2 | regulates | gene | 0.50 |
| VPS37B | regulates | gene | 0.50 |
| IMMUNE RESPONSE | regulates | pathway | 0.50 |
| benchmark_ot_ad_answer_key:ADRA1D | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| adcy9 | regulates | gene | 0.50 |
| benchmark_ot_ad_answer_key:ADRA1D | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||