Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about adcy9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ADCY9 |
| Full Name | Adenylate Cyclase 9 |
| Chromosome | 16p13.3 |
| Protein Type | Enzyme |
| Function | is a member of the adenylate cyclase family of enzymes that catalyze the conversion of ATP to cyclic AMP (cAMP), a key second messenger in cellular signaling. |
| Primary Expression | various tissues, including brain, lung, heart, and platelets |
| Molecular Weight | 150 kDa |
| Amino Acids | 354 aa |
| Pathways | Autophagy, IMMUNE RESPONSE |
| UniProt ID | O60344 |
| NCBI Gene ID | 116 |
| Ensembl ID | ENSG00000100105 |
| GeneCards | ADCY9 |
| Human Protein Atlas | ADCY9 |
| Associated Diseases | neurodegeneration |
| KG Connections | 10 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
ADCY9["ADCY9"]
ADCY9 -->|"regulates"| AUTOPHAGY["AUTOPHAGY"]
ADCY9 -->|"regulates"| SOX2["SOX2"]
ADCY9 -->|"regulates"| CDKN1A["CDKN1A"]
ADCY9 -->|"regulates"| SESN1["SESN1"]
ADCY9 -->|"regulates"| IRF1["IRF1"]
ADCY9 -->|"regulates"| NDRG2["NDRG2"]
ADCY9 -->|"regulates"| SOX9["SOX9"]
ADCY9 -->|"regulates"| MYH2["MYH2"]
PPP5C["PPP5C"] -->|"regulates"| ADCY9
JUN["JUN"] -->|"regulates"| ADCY9
ADRA1D["ADRA1D"] -->|"regulates"| ADCY9
PDK4["PDK4"] -->|"regulates"| ADCY9
LITAF["LITAF"] -->|"regulates"| ADCY9
IL6R["IL6R"] -->|"regulates"| ADCY9
CCND1["CCND1"] -->|"regulates"| ADCY9
MERTK["MERTK"] -->|"regulates"| ADCY9| Source | Relation | Type | Str |
|---|---|---|---|
| PPP5C | regulates | gene | 0.60 |
| JUN | regulates | gene | 0.60 |
| ADRA1D | regulates | gene | 0.60 |
| PDK4 | regulates | gene | 0.60 |
| LITAF | regulates | gene | 0.60 |
| IL6R | regulates | gene | 0.60 |
| MERTK | regulates | gene | 0.60 |
| DUSP1 | regulates | gene | 0.60 |
| MYH2 | regulates | gene | 0.60 |
| NPY1R | regulates | gene | 0.60 |
| CALM2 | regulates | gene | 0.60 |
| VPS37B | regulates | gene | 0.60 |
| NFKBIA | regulates | gene | 0.60 |
| SOX9 | regulates | gene | 0.60 |
| CDKN1A | regulates | gene | 0.60 |
| SESN1 | regulates | gene | 0.60 |
| SOX2 | regulates | gene | 0.60 |
| NDRG2 | regulates | gene | 0.60 |
| CCND1 | regulates | gene | 0.60 |
| HDC | regulates | gene | 0.60 |
| TSC22D3 | regulates | gene | 0.60 |
| MTORC1 | regulates | gene | 0.60 |
| AUTOPHAGY | regulates | gene | 0.60 |
| benchmark_ot_ad_answer_key:ADCY9 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||