Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SCHWANN CELLS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | SCHWANN CELLS |
| Key Genes/Proteins | SFRP1, TREM2 |
| Related Diseases | Somatosensory Neuron Excitability, DIABETES |
| Related Pathways | NLRP3 INFLAMMASOME |
| Linked Hypotheses | 1 hypotheses |
Knowledge base pages for this entity
graph TD
SCHWANN_CELLS["SCHWANN CELLS"]
SCHWANN_CELLS -->|"expressed in"| SFRP1["SFRP1"]
SCHWANN_CELLS -->|"activates"| Somatosensory_Neuron_Excitabil["Somatosensory Neuron Excitability"]
SCHWANN_CELLS -->|"expressed in"| Prostaglandin_E["Prostaglandin E"]
SCHWANN_CELLS -->|"regulates"| SPINAL_CORD["SPINAL CORD"]
PGC_1_["PGC-1alpha"] -->|"expressed in"| SCHWANN_CELLS
GDNF["GDNF"] -->|"interacts"| SCHWANN_CELLS
NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"produces"| SCHWANN_CELLS
INFLAMMATION["INFLAMMATION"] -->|"implicated in"| SCHWANN_CELLS
MICROGLIA["MICROGLIA"] -->|"implicated in"| SCHWANN_CELLS
ASTROCYTES["ASTROCYTES"] -->|"implicated in"| SCHWANN_CELLS
DIABETES["DIABETES"] -->|"implicated in"| SCHWANN_CELLS
MYELIN["MYELIN"] -->|"implicated in"| SCHWANN_CELLS| Target | Relation | Type | Str |
|---|---|---|---|
| SFRP1 | expressed_in | protein | 0.95 |
| Somatosensory Neuron Excitability | activates | phenotype | 0.90 |
| Prostaglandin E | expressed_in | compound | 0.85 |
| MICROGLIA | activates | cell_type | 0.65 |
| SPINAL CORD | associated_with | brain_region | 0.45 |
| SPINAL CORD | regulates | brain_region | 0.35 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TREM2 | inhibits | gene | 0.65 |
| NLRP3 INFLAMMASOME | associated_with | pathway | 0.45 |
| NEUROINFLAMMATION | produces | process | 0.35 |
| INFLAMMATION | implicated_in | process | 0.35 |
| MICROGLIA | implicated_in | cell_type | 0.35 |
| ASTROCYTES | implicated_in | cell_type | 0.35 |
| DIABETES | implicated_in | disease | 0.35 |
| AGING | implicated_in | process | 0.35 |
| NEURON | activates | cell_type | 0.35 |
| MACROPHAGES | activates | cell_type | 0.35 |
| IPSC | regulates | cell_type | 0.35 |
| ALS | regulates | disease | 0.35 |
| OLIGODENDROCYTES | interacts_with | cell_type | 0.35 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| GDNF Gradient Establishment by Schwann Cells Enables Motor R | 0.585 | neurodegeneration | What molecular mechanisms enable functio |
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||