Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SYNAPSE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
SYNAPSE is a concept in neurodegeneration research. Key relationships include: regulates, activates, associated with. Associated with ALS, Aging, Als. Connected to 572 entities in the SciDEX knowledge graph.
| Name | SYNAPSE |
| Summary | Page for Tripartite Synapse |
| Key Genes/Proteins | DEPRESSION |
| Related Diseases | Neurodegeneration, Als, Alzheimer, Inflammation, Neuroinflammation |
| Related Pathways | Complement |
| Linked Hypotheses | 5 hypotheses |
Knowledge base pages for this entity
graph TD
SYNAPSE["SYNAPSE"]
SYNAPSE -->|"regulates"| Parkinson["Parkinson"]
SYNAPSE -->|"regulates"| Prion_Disease["Prion Disease"]
SYNAPSE -->|"regulates"| Huntington["Huntington"]
SYNAPSE -->|"regulates"| Alzheimer["Alzheimer"]
SYNAPSE -->|"regulates"| NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"]
SYNAPSE -->|"regulates"| HUNTINGTON["HUNTINGTON"]
SYNAPSE -->|"regulates"| Cell_Cycle["Cell Cycle"]
BDNF["BDNF"] -->|"expressed in"| SYNAPSE
Complement["Complement"] -->|"activates"| SYNAPSE
PI3K["PI3K"] -->|"regulates"| SYNAPSE
AKT["AKT"] -->|"regulates"| SYNAPSE
SNCA["SNCA"] -->|"regulates"| SYNAPSE
NDUFA9["NDUFA9"] -->|"regulates"| SYNAPSE
GENES["GENES"] -->|"regulates"| SYNAPSE
ALZHEIMER["ALZHEIMER"] -->|"regulates"| SYNAPSE
TUBB3["TUBB3"] -->|"regulates"| SYNAPSE| Target | Relation | Type | Str |
|---|---|---|---|
| Neurodegeneration | activates | disease | 1.00 |
| Als | activates | disease | 1.00 |
| Alzheimer | associated_with | disease | 0.95 |
| Alzheimer | regulates | disease | 0.85 |
| Inflammation | associated_with | disease | 0.85 |
| Als | therapeutic_target | disease | 0.85 |
| Alzheimer | activates | disease | 0.85 |
| Als | associated_with | disease | 0.85 |
| Alzheimer | causes | disease | 0.85 |
| Neuroinflammation | activates | disease | 0.85 |
| Inflammation | activates | disease | 0.85 |
| Alzheimer | therapeutic_target | disease | 0.85 |
| Complement | inhibits | pathway | 0.80 |
| Complement | activates | pathway | 0.80 |
| Huntington | regulates | disease | 0.75 |
| Neuroinflammation | regulates | disease | 0.75 |
| Inflammation | regulates | disease | 0.75 |
| Depression | regulates | disease | 0.75 |
| Neuroinflammation | associated_with | disease | 0.75 |
| Neurodegeneration | regulates | disease | 0.75 |
| Neurodegeneration | associated_with | disease | 0.75 |
| Alzheimer | inhibits | disease | 0.75 |
| Aging | associated_with | disease | 0.75 |
| Aging | therapeutic_target | disease | 0.75 |
| Neurodegeneration | causes | disease | 0.75 |
| Depression | associated_with | disease | 0.75 |
| Als | implicated_in | disease | 0.75 |
| Parkinson | expressed_in | disease | 0.75 |
| Als | expressed_in | disease | 0.75 |
| Aging | expressed_in | disease | 0.75 |
| Neuroinflammation | inhibits | disease | 0.75 |
| Inflammation | inhibits | disease | 0.75 |
| Aging | biomarker_for | disease | 0.75 |
| TAU | associated_with | gene | 0.70 |
| Complement | regulates | pathway | 0.70 |
| ALZHEIMER | associated_with | gene | 0.70 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.70 |
| MICROGLIA | activates | gene | 0.70 |
| ALZHEIMER | activates | gene | 0.70 |
| PROINFLAMMATORY CYTOKINES | activates | gene | 0.70 |
| TAUOPATHY | associated_with | gene | 0.65 |
| Parkinson | regulates | disease | 0.65 |
| Prion Disease | regulates | disease | 0.65 |
| Autism | regulates | disease | 0.65 |
| Aging | regulates | disease | 0.65 |
| Traumatic Brain Injury | regulates | disease | 0.65 |
| ALS | regulates | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| Frontotemporal Dementia | activates | disease | 0.65 |
| Dementia | activates | disease | 0.65 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NEURODEGENERATION | activates | gene | 1.00 |
| ALZHEIMER | associated_with | gene | 0.80 |
| DEPRESSION | associated_with | gene | 0.80 |
| ALZHEIMER | regulates | gene | 0.80 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.80 |
| C1Q | inhibits | gene | 0.80 |
| ALZHEIMER'S DISEASE | regulates | gene | 0.80 |
| NEURODEGENERATIVE DISEASES | activates | gene | 0.80 |
| COMPLEMENT | inhibits | gene | 0.80 |
| GENES | associated_with | gene | 0.80 |
| C1Q | activates | gene | 0.80 |
| ALZHEIMER | causes | gene | 0.80 |
| NEURON | activates | gene | 0.80 |
| NEUROINFLAMMATION | activates | gene | 0.80 |
| TAU | activates | gene | 0.80 |
| CX3CR1 | associated_with | gene | 0.75 |
| MICROGLIA | associated_with | gene | 0.75 |
| BDNF | expressed_in | protein | 0.72 |
| PARKINSON | associated_with | gene | 0.70 |
| NEUROINFLAMMATION | associated_with | gene | 0.70 |
| NEURON | associated_with | gene | 0.70 |
| NEURODEGENERATION | associated_with | gene | 0.70 |
| COMPLEMENT | regulates | gene | 0.70 |
| MICROGLIA | regulates | gene | 0.70 |
| DEPRESSION | regulates | gene | 0.70 |
| GENES | expressed_in | gene | 0.70 |
| NEURODEGENERATION | regulates | gene | 0.70 |
| ASTROCYTES | inhibits | gene | 0.70 |
| ALZHEIMER'S DISEASE | inhibits | gene | 0.70 |
| ALZHEIMER | inhibits | gene | 0.70 |
| PI3K | activates | gene | 0.70 |
| ARC | regulates | gene | 0.70 |
| AGING | associated_with | gene | 0.70 |
| NEURON | interacts_with | gene | 0.70 |
| GENES | contributes_to | gene | 0.70 |
| SYNAPTOPHYSIN | inhibits | gene | 0.70 |
| NEURON | causes | gene | 0.70 |
| COMPLEMENT | activates | gene | 0.70 |
| AMYLOID | activates | gene | 0.70 |
| MICROGLIA | activates | gene | 0.70 |
| ASTROCYTES | implicated_in | gene | 0.70 |
| CYTOKINES | activates | gene | 0.70 |
| PARKINSON'S DISEASE | expressed_in | gene | 0.70 |
| PARKINSON | expressed_in | gene | 0.70 |
| NEURON | expressed_in | gene | 0.70 |
| NEURODEGENERATIVE DISEASES | implicated_in | gene | 0.70 |
| ALZHEIMER'S DISEASE | activates | gene | 0.70 |
| ALZHEIMER | therapeutic_target | gene | 0.70 |
| ALZHEIMER'S DISEASE | therapeutic_target | gene | 0.70 |
| AMYLOID | causes | gene | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| H1: TREM2 Agonism to Redirect APOE4-Enhanced Microglia from | 0.588 | neurodegeneration | How does APOE4's beneficial immune funct |
| SASP-Mediated Cholinergic Synapse Disruption | 0.564 | neurodegeneration | Senolytic therapy for age-related neurod |
| TBK1 Loss-of-Function Amplifies C1q-Mediated Synapse Elimina | 0.520 | neurodegeneration | How do the seven novel ALS genes functio |
| Cross-Cell Type Synaptic Rescue via Tripartite Synapse Resto | 0.454 | neurodegeneration | Cell type vulnerability in Alzheimer's D |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.455
neuro-oncology | 2026-04-13 | 0 hypotheses
synaptic biology | 2026-04-07 | 0 hypotheses
synaptic biology | 2026-04-07 | 0 hypotheses
neurodegeneration | 2026-04-04 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Clinical, Immunological, and Vesicular Markers in Sarcopenia and Presarcopenia. [PMID:40917056] | Shuliko LM, Svarovsky DA, Spirina LV, Og | Front Biosci (Landmark Ed) | 2025 | 1 |
| CD47-blocking antibody interferes with neutrophil extracellular traps formation [PMID:39951937] | Diao Y, Hao M, Xie M, Hu X, Tan R, Wang | J Neuroimmunol | 2025 | 1 |
| Asparagine Endopeptidase Inhibition Attenuates Tissue Plasminogen Activator-Indu [PMID:40116141] | Xie G, Jiang G, Huang L, Sun S, Li X, Wu | CNS Neurosci Ther | 2025 | 1 |
| Enhanced anticancer activity of nanoemulsified cardamom extract via modulation o [PMID:41658858] | ["Soltani T", "Karimian M", "Vaziri H", | Biochemistry and biophysics re | 2026 | 0 |
| Integrated transcriptomic, proteomic, and metabolomic analyses reveal molecular [PMID:41850064] | ["Wang H", "Liu Y", "Jiang K", "Yin J", | Poultry science | 2026 | 0 |
| Fragment merging design, synthesis, and biological evaluation of novel methyl Se [PMID:41785527] | ["Shaaban S", "Hawas S", "Elmaaty A", "B | Bioorganic & medicinal chemist | 2026 | 0 |
| Theranekron modulates extracellular matrix and apoptotic signaling pathways in c [PMID:41852375] | ["Kuccukturk S", "Duran T", "Vanli S", " | Cytotechnology | 2026 | 0 |
| Saliva liquid biopsy: MMP2, MMP9, and TIMP2 as potential diagnostic biomarkers i [PMID:41779471] | ["Cruz-Romero S", "Baldi\u00f3n A", "Taw | Journal of applied oral scienc | 2026 | 0 |
| Glomerular Transcriptome Analysis Reveals Endothelial Disturbances in Patients W [PMID:41659822] | ["Nelson-Taylor S", "Troost J", "Giannin | Kidney medicine | 2026 | 0 |
| Encapsulation of hydroxyurea in exosomes derived from adipose mesenchymal stem c [PMID:41702234] | ["Taheri Kangarshahi Z", "Ganji S", "Ash | Translational oncology | 2026 | 0 |
| NSUN2 promoted tumor growth and metastatic via m [PMID:41794778] | ["Li R", "Jin D", "Shao S", "Guo J"] | Cell death & disease | 2026 | 0 |
| Membrane-Type 5 Matrix Metalloproteinase (MT5-MMP): Background and Proposed Role [PMID:40867559] | ["Jadhav D", "Knapinska A", "Wang H", "F | Biomolecules | 2025 | 0 |
| Pyridostigmine Treatment Significantly Alleviates Isoprenaline-Induced Chronic H [PMID:40725139] | Marinković ST, Sobot T, Maksimović ŽM, Ð | International journal of molec | 2025 | 0 |
| Effects of Mono- (2-ethylhexyl) phthalate and Phthalic Acid Monobenzyl Ester on [PMID:40769497] | ["Wu Q", "Sun Y", "Liu Q", "Zhao X", "Li | Reproductive toxicology (Elmsf | 2025 | 0 |
| Targeting Invasion: The Role of MMP-2 and MMP-9 Inhibition in Colorectal Cancer [PMID:39858430] | ["Shoari A", "Ashja Ardalan A", "Dimesa | Biomolecules | 2024 | 0 |
| Effects of MMP2 and its inhibitor TIMP2 on DNA damage, apoptosis and senescence [PMID:39538054] | ["Deng X", "Zhang Y", "He X", "Li L", "Y | Journal of bioenergetics and b | 2024 | 0 |
| Biological significance and pathophysiological role of Matrix Metalloproteinases [PMID:39322129] | ["Ganguly K", "Adhikary K", "Acharjee A" | International journal of biolo | 2024 | 0 |
| Reduced inhibitory and excitatory input onto parvalbumin interneurons mediated b [PMID:36543316] | ["Zhang L", "Gao Y", "Zhao C", "Xia J", | Neuropharmacology | 2023 | 0 |
| Unlocking the potential of iridium and ruthenium arene complexes as anti-tumor a [PMID:36370504] | Lv M, Qian X, Li S, Gong J, Wang Q, Qian | Journal of inorganic biochemis | 2023 | 0 |
| Low protein-induced intrauterine growth restriction as a risk factor for schizop [PMID:36720849] | ["Allg\u00e4uer L", "Cabungcal J", "Yzyd | Translational psychiatry | 2023 | 0 |