concept

FINGOLIMOD

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FINGOLIMOD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

60Connections

0Hypotheses

2Analyses

40Outgoing

20Incoming

0Experiments

2Debates

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💡 Concept Info

Name	FINGOLIMOD
Key Genes/Proteins	ALPHA-SYNUCLEIN, BDNF, CD4
Related Diseases	ALZHEIMER, ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS, CERAMIDE, INFLAMMATION

Pathway Diagram

graph TD
    FINGOLIMOD["FINGOLIMOD"]
    FINGOLIMOD -->|"treats"| Ischemic_Brain_Injury["Ischemic Brain Injury"]
    FINGOLIMOD -->|"inhibits"| HMGB1_TLR4_NF__B_Signaling_Pat["HMGB1/TLR4/NF-kappaB Signaling Pathway"]
    FINGOLIMOD -->|"downregulates"| IL_1_["IL-1beta"]
    FINGOLIMOD -->|"downregulates"| IL_6["IL-6"]
    FINGOLIMOD -->|"downregulates"| TNF__["TNF-alpha"]
    FINGOLIMOD -->|"inhibits"| S1P_RECEPTOR["S1P RECEPTOR"]
    FINGOLIMOD -->|"inhibits"| T_Cell_Infiltration["T Cell Infiltration"]
    FINGOLIMOD -->|"treats"| Neuroinflammation["Neuroinflammation"]
    Bezafibrate["Bezafibrate"] -->|"interacts"| FINGOLIMOD
    ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"] -->|"inhibits"| FINGOLIMOD
    CD4["CD4"] -->|"inhibits"| FINGOLIMOD
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"metabolizes"| FINGOLIMOD

Outgoing (40)

Target	Relation	Type	Str
Ischemic Brain Injury	treats	disease	0.95
HMGB1/TLR4/NF-κB Signaling Pathway	inhibits	pathway	0.92
IL-1β	downregulates	protein	0.92
TNF-α	downregulates	protein	0.92
IL-6	downregulates	protein	0.92
S1P RECEPTOR	inhibits	receptor	0.90
S1PR1	associated_with	protein	0.90
Neuroinflammation	treats	process	0.85
CD4 T Cell Infiltration	inhibits	process	0.85
T Cell Infiltration	inhibits	process	0.85
H2-Ea Upregulation	associated_with	process	0.80
CNS_safety	demonstrates	phenotype	0.70
MICROGLIA	targets	cell_type	0.65
NLRP3 INFLAMMASOME	inhibits	pathway	0.65
NLRP3	inhibits	gene	0.65
CERAMIDE	encodes	phenotype	0.65
STING	treats	gene	0.65
MICROGLIA	inhibits	cell_type	0.65
BDNF	causes	gene	0.65
STING	inhibits	gene	0.65
Alzheimer's disease	treats	disease	0.60
unfolded protein response	modulates	pathway	0.60
CD4	associated_with	gene	0.60
CERS2	regulates	gene	0.60
SGMS1	associated_with	gene	0.60
CERS2	activates	gene	0.60
NEUROINFLAMMATION	inhibits	phenotype	0.56
PD1	associated_with	gene	0.50
CERAMIDE	associated_with	phenotype	0.45
ALZHEIMER	associated_with	disease	0.45
NEURONS	associated_with	cell_type	0.45
ASTROCYTE	associated_with	cell_type	0.45
STRIATUM	associated_with	brain_region	0.45
NLRP3	associated_with	gene	0.45
TREM2	associated_with	gene	0.45
BDNF	associated_with	gene	0.45
IBUDILAST	associated_with	drug	0.45
MICROGLIA	associated_with	cell_type	0.45
NEURON	inhibits	cell_type	0.35
HIPPOCAMPUS	activates	brain_region	0.35

Incoming (20)

Source	Relation	Type	Str
Bezafibrate	interacts_with	drug	0.80
NLRP3	treats	gene	0.65
NLRP3 INFLAMMASOME	activates	pathway	0.65
HUNTINGTON	enhances	gene	0.50
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	disease	0.45
NLRP3 INFLAMMASOME	associated_with	pathway	0.45
OXIDATIVE STRESS	associated_with	phenotype	0.45
INFLAMMATION	associated_with	phenotype	0.45
MINOCYCLINE	associated_with	drug	0.45
MULTIPLE SCLEROSIS	associated_with	disease	0.45
TRAUMATIC BRAIN INJURY	associated_with	disease	0.45
ALZHEIMER	associated_with	disease	0.45
CERAMIDE	associated_with	phenotype	0.45
METABOLIC REPROGRAMMING	associated_with	phenotype	0.45
SPHINGOMYELIN	associated_with	phenotype	0.45
DIMETHYL FUMARATE	associated_with	drug	0.45
NEUROINFLAMMATION	associated_with	phenotype	0.45
ALZHEIMER'S DISEASE	associated_with	disease	0.45
ALPHA-SYNUCLEIN	inhibits	gene	0.35
CD4	inhibits	gene	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Why do clinical manifestations overlap despite distinct underlying etiologies in

neuroinflammation | 2026-04-08 | 7 hypotheses Top: 0.455

Lipid metabolism dysregulation and membrane integrity in Alzheimer disease

neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.380

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

How do alterations in brain lipid metabolism—including gangliosides, phospholipi

closed · Rounds: 4 · Score: 0.84 · 2026-04-11

The abstract notes that clinical presentations overlap across different myelopat

closed · Rounds: 4 · Score: 0.86 · 2026-04-09

Related Research

Hypotheses and analyses mentioning FINGOLIMOD in their description or question text

No additional research found