disease

Dysbiosis

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Dysbiosis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

359Connections

0Hypotheses

4Analyses

32Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	CRHR1, Prion, STROKE, GLAUCOMA, TLR4, INFLAMMATION, AGING, MITOCHONDRIAL DYSFUNCTION
KG Connections	351 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Dysbiosis["<b>Dysbiosis</b>"]
    Parkinson_s_Disease{"Parkinson's Disease"}
    Dysbiosis -->|"risk_factor_for"| Parkinson_s_Disease
    Neuroinflammation["Neuroinflammation"]
    Dysbiosis -->|"causes"| Neuroinflammation
    Blood_Brain_Barrier_Permeabili["Blood-Brain Barrier Permeability"]
    Dysbiosis -->|"causes"| Blood_Brain_Barrier_Permeabili
    Inflammation{"Inflammation"}
    Inflammation -->|"associated_with"| Dysbiosis
    Als{"Als"}
    Als -->|"therapeutic_target"| Dysbiosis
    INFLAMMATION(["INFLAMMATION"])
    INFLAMMATION -->|"associated_with"| Dysbiosis
    style Dysbiosis fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#e0e0e0

Outgoing (38)

Target	Relation	Type	Str
Neuroinflammation	causes	process	0.90
Parkinson's Disease	risk_factor_for	disease	0.90
Oxidative Stress	contributes_to	process	0.90
Oxidative Stress	promotes	process	0.90
Neuroinflammation	promotes	process	0.90
NEUROINFLAMMATION	contributes_to	process	0.88
Blood-Brain Barrier Permeability	causes	phenotype	0.85
Alzheimer's Disease	risk_factor_for	disease	0.85
Parkinson's Disease	associated_with	disease	0.85
Parkinson'S Disease	causes	disease	0.85
Retinal Ganglion Cell Degeneration	mediates	process	0.85
Blood-Brain Barrier Integrity	associated_with	phenotype	0.85
Neurodegenerative Diseases	causes	disease	0.70
NLRP3	activates	gene	0.70
Gut Microbiota	interacts_with	process	0.50
Gut Microbiota	associated_with	process	0.50
Gut Microbiota	causes	process	0.50
MAPK SIGNALING	activates	concept	0.50
Gut Microbiota	inhibits	process	0.50
SYNUCLEIN	associated_with	concept	0.50
α-SYNUCLEIN	associated_with	concept	0.50
Gut Microbiota	regulates	process	0.50
CENTRAL NERVOUS SYSTEM	associated_with	concept	0.50
Gut Microbiota	activates	process	0.50
Telomere	inhibits	pathway	0.50
Gut Microbiome	activates	process	0.50
Telomere	activates	pathway	0.50
Reactive Oxygen Species	activates	process	0.50
Telomere	regulates	pathway	0.50
Proteostasis	regulates	process	0.50
Cellular Senescence	regulates	cell_type	0.50
CHRONIC INFLAMMATION	regulates	concept	0.50

Incoming (321)

Source	Relation	Type	Str
Inflammation	associated_with	disease	1.00
Als	therapeutic_target	disease	1.00
Als	associated_with	disease	1.00
INFLAMMATION	associated_with	gene	0.90
AGING	associated_with	gene	0.90
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.90
Aging	associated_with	disease	0.90
PARKINSON'S DISEASE	therapeutic_target	gene	0.90
PARKINSON	therapeutic_target	gene	0.90
Parkinson	therapeutic_target	disease	0.90
INFLAMMATION	activates	gene	0.90
Inflammation	activates	disease	0.90
Als	activates	disease	0.90
ALZHEIMER	regulates	gene	0.80
Alzheimer	regulates	disease	0.80
Senescence	associated_with	disease	0.80
INFLAMMATION	treats	gene	0.80
Inflammation	treats	disease	0.80
OXIDATIVE STRESS	associated_with	gene	0.80
INFLAMMATION	causes	gene	0.80
Inflammation	causes	disease	0.80
Inflammation	regulates	disease	0.80
IL-6	therapeutic_target	gene	0.80
NEURODEGENERATIVE DISEASES	associated_with	gene	0.80
Inflammation	therapeutic_target	disease	0.80
NEUROINFLAMMATION	interacts_with	gene	0.70
Als	regulates	disease	0.70
Neuroinflammation	interacts_with	disease	0.70
Inflammation	interacts_with	disease	0.70
NEUROINFLAMMATION	treats	gene	0.70
Neuroinflammation	treats	disease	0.70
FERROPTOSIS	associated_with	gene	0.70
NEUROINFLAMMATION	associated_with	gene	0.70
Neuroinflammation	associated_with	disease	0.70
CYTOKINES	activates	gene	0.70
GUT-BRAIN AXIS	treats	gene	0.70
DNA	activates	gene	0.70
Inflammatory Bowel Disease	activates	disease	0.70
CANCER	activates	gene	0.70
Cancer	activates	disease	0.70
ALZHEIMER	associated_with	gene	0.70
PARKINSON	associated_with	gene	0.70
Parkinson	associated_with	disease	0.70
Alzheimer	associated_with	disease	0.70
DEPRESSION	therapeutic_target	gene	0.70
Depression	therapeutic_target	disease	0.70
TNF	activates	gene	0.70
BDNF	activates	gene	0.70
IL-6	activates	gene	0.70
TNF-Α	activates	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (4)

Scientific analyses that reference this entity

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 0 hypotheses

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 0 hypotheses

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 20 hypotheses Top: 0.617

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Dysbiosis

Understanding Entity Pages

Wiki Pages (20)

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

CBS/PSP Supplements Guide

Device Therapies Comparison for CBS/PSP

CBS/PSP Rehabilitation Master Guide

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

CBS/PSP Treatment Rankings

nct07165106

gabaergic-dysfunction

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

rankings

protective-strategies-cbs-psp

Sulforaphane and Nrf2 Activation for Neuroprotection

dimethyl-fumarate-nrf2-ad-nct06850597

Infectious Triggers in Alzheimer's Disease

lithium-tauopathy

Section 147: Telehealth and Remote Monitoring in CBS/PSP

rankings

NACET (N-Acetylcysteine Ethyl Ester)

GBA1→GCase→Lysosome→PD Causal Chain

Experiment Prioritization Index — Neurodegeneration

Pathway Diagram

Outgoing (38)

Incoming (321)

Targeting Hypotheses (0)

Mentioning Analyses (4)

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

Related Papers (0)