Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MITOSIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | MITOSIS |
| Key Genes/Proteins | AURKA, DNAJB6, IFS, PIEZO1 |
| Related Pathways | Erk Signaling |
graph TD
MITOSIS["MITOSIS"]
CANCER["CANCER"] -->|"activates"| MITOSIS
Cancer["Cancer"] -->|"activates"| MITOSIS
Tumor["Tumor"] -->|"activates"| MITOSIS
Als["Als"] -->|"activates"| MITOSIS
PIEZO1["PIEZO1"] -->|"activates"| MITOSIS
IFS["IFS"] -->|"contributes to"| MITOSIS
APC["APC"] -->|"target for"| MITOSIS| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| PIEZO1 | activates | gene | 0.70 |
| Als | activates | disease | 0.70 |
| CANCER | activates | gene | 0.70 |
| Cancer | activates | disease | 0.70 |
| Tumor | activates | disease | 0.70 |
| PIEZO1 | activates | gene | 0.70 |
| IFS | contributes_to | protein | 0.64 |
| CANCER | therapeutic_target | gene | 0.60 |
| Tumor | therapeutic_target | disease | 0.60 |
| Cancer | therapeutic_target | disease | 0.60 |
| Als | therapeutic_target | disease | 0.60 |
| ERK | regulates | gene | 0.60 |
| GLIOBLASTOMA | activates | gene | 0.60 |
| Glioma | regulates | disease | 0.60 |
| Glioblastoma | activates | disease | 0.60 |
| ERK | activates | gene | 0.60 |
| YAP | activates | gene | 0.60 |
| APC | therapeutic_target | gene | 0.60 |
| E2F1 | activates | gene | 0.60 |
| ENO1 | activates | gene | 0.60 |
| PDK3 | activates | gene | 0.60 |
| HK2 | activates | gene | 0.60 |
| PDK1 | activates | gene | 0.60 |
| MYC | activates | gene | 0.60 |
| FOS | activates | gene | 0.60 |
| EGFR | activates | gene | 0.60 |
| P38 | activates | gene | 0.60 |
| EGF | activates | gene | 0.60 |
| JUN | activates | gene | 0.60 |
| SRC | activates | gene | 0.60 |
| ATG | regulates | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| LYSOSOME | regulates | gene | 0.60 |
| DNA | activates | gene | 0.60 |
| Als | regulates | disease | 0.60 |
| CYCLIN B1 | regulates | gene | 0.60 |
| CDK1 | regulates | gene | 0.60 |
| PDK1 | regulates | gene | 0.60 |
| AKT | regulates | gene | 0.60 |
| UBIQUITIN | activates | gene | 0.60 |
| Colorectal Cancer | activates | disease | 0.60 |
| GENES | activates | gene | 0.60 |
| DDB1 | activates | gene | 0.60 |
| WIPI2 | activates | gene | 0.60 |
| PI3K | regulates | gene | 0.60 |
| Erk Signaling | activates | pathway | 0.50 |
| PIEZO1 | activates | gene | 0.50 |
| DNAJB6 | regulates | gene | 0.50 |
| AURKA | regulates | protein | 0.50 |
| CELL CYCLE | regulates | cell_type | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity