concept

BRAFV600E

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BRAFV600E: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

72Connections

0Hypotheses

0Analyses

50Outgoing

13Incoming

0Experiments

0Debates

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💡 Concept Info

Name	BRAFV600E
Key Genes/Proteins	AKT, AND, BRAF, CANCER, CD8, CYTOKINES
Related Diseases	Als, ALS, Cancer, Carcinoma, Colorectal Cancer
Related Pathways	Angiogenesis, Blood-Brain Barrier, Checkpoint Inhibitor

Pathway Diagram

graph TD
    BRAFV600E["BRAFV600E"]
    BRAFV600E -.biomarker for.-> Langerhans_Cell_Histiocytosis["Langerhans Cell Histiocytosis"]
    BRAFV600E -->|"activates"| MAPK["MAPK"]
    BRAFV600E -->|"causes"| Colorectal_Cancer["Colorectal Cancer"]
    BRAFV600E -->|"causes"| Cancer["Cancer"]
    BRAFV600E -->|"causes"| Melanoma["Melanoma"]
    BRAFV600E -->|"target for"| Tumor["Tumor"]
    BRAFV600E -->|"expressed in"| Carcinoma["Carcinoma"]
    ERK["ERK"] -->|"inhibits"| BRAFV600E
    KRAS["KRAS"] -->|"expressed in"| BRAFV600E
    CYTOKINES["CYTOKINES"] -->|"target for"| BRAFV600E
    MAPK -->|"causes"| BRAFV600E
    INFLAMMATION["INFLAMMATION"] -->|"activates"| BRAFV600E
    NEURODEGENERATION["NEURODEGENERATION"] -->|"activates"| BRAFV600E
    AND["AND"] -->|"activates"| BRAFV600E
    DNA["DNA"] -->|"expressed in"| BRAFV600E

Outgoing (59)

Target	Relation	Type	Str
Langerhans Cell Histiocytosis	biomarker_for	disease	0.90
MAPK	activates	pathway	0.70
Neurodegeneration	causes	disease	0.65
ALS	causes	disease	0.65
Cancer	causes	disease	0.65
Inflammation	activates	disease	0.65
Tumor	associated_with	disease	0.65
Melanoma	causes	disease	0.65
Colorectal Cancer	causes	disease	0.65
Neurodegeneration	activates	disease	0.65
ALS	activates	disease	0.65
Melanoma	inhibits	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Tumor	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	causes	disease	0.65
Tumor	biomarker_for	disease	0.65
Carcinoma	expressed_in	disease	0.65
Als	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
DNA	expressed_in	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
AND	inhibits	gene	0.60
BRAF	inhibits	gene	0.60
Raf	associated_with	protein	0.60
Raf	activates	protein	0.60
CANCER	therapeutic_target	gene	0.60
Rb	therapeutic_target	protein	0.60
CD8	therapeutic_target	gene	0.60
Blood-Brain Barrier	therapeutic_target	pathway	0.60
Immunotherapy	inhibits	pathway	0.60
Immune Response	therapeutic_target	pathway	0.60
Checkpoint Inhibitor	therapeutic_target	pathway	0.60
Metastasis	inhibits	pathway	0.60
Immune Checkpoint	therapeutic_target	pathway	0.60
Neuron	causes	cell_type	0.60
DNA	biomarker_for	gene	0.60
glioblastoma	biomarker_for	disease	0.60
neurodegeneration	biomarker_for	disease	0.60
oxidative stress response	participates_in	pathway	0.60
CANCER	causes	gene	0.60
MAPK	causes	gene	0.60
AND	causes	gene	0.60
NEURODEGENERATIVE DISEASES	causes	gene	0.60
Mapk	causes	pathway	0.60
INFLAMMATION	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
AND	activates	gene	0.60
NEURODEGENERATION	causes	gene	0.60
AKT	associated_with	gene	0.60

Incoming (13)

Source	Relation	Type	Str
MAPK	causes	gene	0.60
ERK	associated_with	gene	0.60
BRAF	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
TP53	associated_with	gene	0.60
ERK	inhibits	gene	0.60
KRAS	expressed_in	gene	0.60
CYTOKINES	therapeutic_target	gene	0.60
INFLAMMATION	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
AND	activates	gene	0.60
BRAF	inhibits	gene	0.60
DNA	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity