gene 1,270 words KG: HSPB8
Contents

HSPB8 Gene

🧬 Gene Info
Gene SymbolHSPB8
Full NameHeat Shock Protein Family B Member 8
Chromosome21q22.3
Protein FamilySmall heat shock protein (sHsp)
Subcellular LocalizationCytosol, mitochondria
Molecular Weight22 kDa
Amino Acids196
Gene TypeProtein coding
PathwaysAutophagy
UniProt IDQ9UJX1
NCBI Gene ID23673
Ensembl IDENSG00000169435
OMIM607655
GeneCardsHSPB8
Human Protein AtlasHSPB8
Associated DiseasesALS, Amyotrophic Lateral Sclerosis, Ataxia, Huntington, Neuroblastoma
Known Drugs/Compoundsrapamycin
InteractionsATG10, CALCINEURIN, ATG12, BAG3, STUB1, UBIQUITIN
KG Connections217 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (8)

HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor
Score: 0.42
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Lysosomal Calcium Channel Modulation Therapy
Score: 0.49
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.48
Cryptic Exon Silencing Restoration
Score: 0.46

Related Analyses (3)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

Gene expression analysis of autophagy targets following treh
exploratory · proposed · Score: 0.85
Trehalose-induced autophagy gene expression analysis
exploratory · proposed · Score: 0.85

See Also (8)

Packard Center for ALS Research
institution · KG edge: associated_with
BECN1 Gene
gene · KG edge: activates
BCL2 Gene
gene · KG edge: activates
BAG3 Gene
gene · KG edge: associated_with
ATG12 — Autophagy Related 12
gene · KG edge: activates

Knowledge Graph (12 edges)

HSPB8 regulates LAMP2A
HSPB8 regulates MAP1LC3B
HSPB8 regulates MCOLN1
HSPB8 regulates P62
HSPB8 regulates PPARGC1A
HSPB8 regulates SQSTM1
HSPB8 regulates TFEB
HSPB8 regulates TPP1
HSPB8 activates LAMP1
HSPB8 activates LAMP2A