| Gene Symbol | PRKN |
| Full Name | Parkin RBR E3 Ubiquitin Protein Ligase |
| Chromosome | 6q26 |
| Protein Type | Ligase |
| Function | is a gene located on chromosome 6q26 that encodes an E3 ubiquitin ligase essential for mitochondrial quality control and mitophagy[@kitada1998]. |
| Primary Expression | Substantia nigra, Striatum, Cortex, Heart, Skeletal muscle |
| Pathways | Autophagy, E3 Ligase Activity, Glycolysis, Mitophagy, Oxidative Stress |
| UniProt ID | O60260 |
| NCBI Gene ID | 5071 |
| Ensembl ID | ENSG00000185348 |
| OMIM | 602544 |
| GeneCards | PRKN |
| Human Protein Atlas | PRKN |
| Unique Palmitoylation Site | Cysteine 431 for membrane association |
| RING0 domain | Inhibitory regulatory domain |
| Associated Diseases | AD, Aging, ALI, Als, Alzheimer |
| Known Drugs/Compounds | dimethyl fumarate, FB231, Fumarate, nicotinamide, rapamycin |
| Interactions | ABCD3, ABP, ACTB, Actin, AIF1, AIFM1 |
| KG Connections | 1622 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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