gene 2,479 words KG: SLC2A1 2026-03-29
section:geneskind:genetopic:alzheimerstopic:parkinsons
Contents

SLC2A1 Gene

🧬 Gene Info
Gene SymbolSLC2A1
Full NameSolute Carrier Family 2 Member 1 (Glucose Transporter 1)
Chromosome1p34.2
Protein TypeTransporter
Functionis a facilitative glucose transporter belonging to the SLC2A family that provides the critical link between systemic glucose supply and cerebral energy metabolism.
Molecular Weight~54 kDa
Amino Acids492 aa
Exons10
PathwaysFerroptosis, Mapk, Oxidative Stress, autophagy pathway, unfolded protein response
UniProt IDP11166
NCBI Gene ID6513
Ensembl IDENSG00000117394
OMIM138140
GeneCardsSLC2A1
Human Protein AtlasSLC2A1
Associated DiseasesAls, Ataxia, Cancer, Carcinoma, Infection, Ms
InteractionsCOX4I1, GSK3B, IGF1, PPAR, MEF2C, NRF2
KG Connections234 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (13)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
CYP46A1 Overexpression Gene Therapy
Score: 0.63
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.57
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51
Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.48

Related Analyses (6)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: inhibits
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: activates
CAT — Catalase
gene · KG edge: inhibits

Knowledge Graph (12 edges)

SLC2A1 inhibits COX4I1
SLC2A1 inhibits GSK3B
SLC2A1 protects_against AKT
SLC2A1 activates IGF1
SLC2A1 activates PPAR
SLC2A1 activates MEF2C
SLC2A1 activates NRF2
SLC2A1 co_discussed STING
SLC2A1 inhibits NRXN3
SLC2A1 inhibits PRKAA1