disease

MS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5783Connections

4Hypotheses

30Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	B4GALT6, RBP, STING, ACSL4, JNK, p38 MAPK, SPINK5, STS
KG Connections	272 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

therapeutic · 15794 words

→

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Pathway Diagram

graph TD
    MS["MS"] -->|"causes"| DEMYELINATION["DEMYELINATION"]
    style DEMYELINATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    MS["MS"] -->|"causes"| NEURODEGENERATION["NEURODEGENERATION"]
    style NEURODEGENERATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    MS["MS"] -->|"causes"| AXONAL_DAMAGE["AXONAL_DAMAGE"]
    style AXONAL_DAMAGE fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    MS["MS"] -->|"regulates"| CNS["CNS"]
    style CNS fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    MS["MS"] -->|"associated"| OXPCS["OXPCS"]
    style OXPCS fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    MS["MS"] -->|"causes"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
    style NEUROINFLAMMATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    MS["MS"] -->|"causes"| STING["STING"]
    style STING fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    STING_1["STING"] -->|"implicated in"| MS["MS"]
    style STING_1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    SPINK5["SPINK5"] -->|"associated"| MS["MS"]
    style SPINK5 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    STS["STS"] -->|"associated"| MS["MS"]
    style STS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    B_cells["B cells"] -->|"associated"| MS["MS"]
    style B_cells fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    INFLAMMATION_1["INFLAMMATION_1"] -->|"causes"| MS["MS"]
    style INFLAMMATION_1 fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    style MS fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (513)

Target	Relation	Type	Str
DEMYELINATION	causes	phenotype	1.00
NEURODEGENERATION	causes	phenotype	1.00
AXONAL_DAMAGE	causes	phenotype	0.79
CNS	regulates	brain_region	0.72
OXPCS	associated_with	protein	0.72
NEUROINFLAMMATION	causes	phenotype	0.72
neurodegeneration	associated_with	phenotype	0.72
STING	causes	protein	0.72
AXONAL_LOSS	causes	phenotype	0.64
BRAIN_ATROPHY	causes	phenotype	0.64
NEURODEGENERATIVE DISEASES	treats	gene	0.60
PARKINSON'S DISEASE	causes	gene	0.60
NEURODEGENERATION	implicated_in	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
STAT3	regulates	gene	0.60
NEURODEGENERATIVE DISEASES	implicated_in	gene	0.60
PARKINSON'S DISEASE	implicated_in	gene	0.60
NEUROINFLAMMATION	interacts_with	gene	0.60
PARKINSON'S DISEASE	interacts_with	gene	0.60
STROKE	interacts_with	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
STROKE	activates	gene	0.60
TAU	activates	gene	0.60
NEURODEGENERATIVE DISEASES	protects_against	gene	0.60
PARKINSON'S DISEASE	protects_against	gene	0.60
STROKE	protects_against	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
PARKINSON'S DISEASE	regulates	gene	0.60
PARKINSON'S DISEASE	treats	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
OXIDATIVE STRESS	targets	gene	0.60
NEURODEGENERATION	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
NF-ΚB	inhibits	gene	0.60
NF-ΚB	activates	gene	0.60
NLRP3	activates	gene	0.60
NEURODEGENERATION	treats	gene	0.60
OXIDATIVE STRESS	interacts_with	gene	0.60
TNF	inhibits	gene	0.60
NEURONS	activates	cell_type	0.60
TNF	activates	gene	0.60
NEURON	causes	gene	0.60
NEURON	protects_against	gene	0.60
NEURONS	protects_against	cell_type	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
TREM2	implicated_in	gene	0.60
TNF	regulates	gene	0.60
TUMOR	regulates	disease	0.60

Incoming (5270)

Source	Relation	Type	Str
STING	implicated_in	protein	0.80
SPINK5	associated_with	gene	0.80
STS	associated_with	gene	0.80
B cells	associated_with	cell_type	0.80
INFLAMMATION_1	causes	phenotype	0.72
ACSL4	associated_with	protein	0.70
S1P	implicated_in	entity	0.70
S1P receptors	implicated_in	receptor	0.70
gut microbiota	associated_with	biological_process	0.70
CD19	biomarker_for	protein	0.70
B4GALT6	associated_with	gene	0.64
JNK	implicated_in	protein	0.60
p38 MAPK	implicated_in	protein	0.60
ALS	treats	disease	0.60
ALS	causes	disease	0.60
ALZHEIMER'S DISEASE	causes	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	causes	gene	0.60
HUNTINGTON	causes	gene	0.60
MITOCHONDRIAL DYSFUNCTION	implicated_in	gene	0.60
AUTOPHAGY	implicated_in	gene	0.60
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.60
ALZHEIMER'S DISEASE	implicated_in	gene	0.60
MICROGLIA	treats	gene	0.60
ALS	interacts_with	disease	0.60
ALZHEIMER'S DISEASE	interacts_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	interacts_with	gene	0.60
ALS	activates	disease	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
AMYLOID	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
ALZHEIMER'S DISEASE	protects_against	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
HUNTINGTON	regulates	gene	0.60
ALZHEIMER'S DISEASE	treats	gene	0.60
INFLAMMATION	implicated_in	gene	0.60
CYTOKINES	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
ASTROCYTE	inhibits	gene	0.60
ASTROCYTE	activates	gene	0.60
AGING	interacts_with	gene	0.60
CYTOKINES	interacts_with	gene	0.60
MITOCHONDRIAL DYSFUNCTION	interacts_with	gene	0.60
ASTROCYTES	interacts_with	gene	0.60
ASTROCYTE	causes	gene	0.60
MICROGLIA	causes	gene	0.60
ASTROCYTE	targets	gene	0.60
CYTOKINES	implicated_in	gene	0.60
APOPTOSIS	activates	gene	0.60
DEMENTIA	activates	gene	0.60

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
GPC4/HSPGs Collaborate with ApoE Isoforms to Dictate Tau Con	0.583	neurodegeneration	What are the specific molecular determin
SGMS1-Driven Sphingomyelin Accumulation Impairs BACE1 Lysoso	0.542	neurodegeneration	What molecular mechanisms link elevated
Acid-Degradable LNP-Mediated Prenatal CRISPR Intervention fo	0.465	neurodegeneration	CRISPR-based therapeutic approaches for
Synthetic Biology Approach: Designer Mitochondrial Export Sy	0.358	neurodegeneration	Mitochondrial transfer between neurons a

Mentioning Analyses (30)

Scientific analyses that reference this entity

How does engineered C. butyricum cross the blood-brain barrier to directly bind

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.675

How does SYNGAP1, a 'synaptic' protein, function in pre-synaptic radial glia cel

neurodevelopment | 2026-04-15 | 1 hypotheses Top: 0.576

What molecular mechanisms link elevated sphingomyelin synthase activity to incre

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.542

Why does PRKN-mediated mitophagy, typically protective, cause harmful mitochondr

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.455

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.578

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Integrating biocatalysis with continuous flow: current status, challenges, and f [PMID:40639553]	Bai J, Huang C, Liu Y, Zheng X, Liu J et	J Adv Res	2026
Engineering chimeric signaling proteins for microbial whole-cell biosensors: fro [PMID:40903364]	Özer Bergman G, Mecacci S, Martins Dos S	Trends Biotechnol	2026
MTAP Deletion in Oncogenesis: A Synthetic Lethality Scenario. [PMID:41512197]	Rodon J, Johnson ML, George B, Shah PA,	Cancer Res	2026
Engineering the Caenorhabditis elegans genome with a nested, self-excising selec [PMID:41557645]	Gibney TV, Pani AM	Genetics	2026
Design and synthesis of BAP-1 inhibitors. [PMID:41761813]	Zhang Z, Yang X	Pak J Pharm Sci	2026
Optimized bacterial expression of a synthetic BRIL antibody. [PMID:41842660]	Cooper BF, Isom GL	Acta Crystallogr F Struct Biol	2026
Chemogenetic Modulation of Luciferase Emission Color for Imaging and Sensing. [PMID:41941277]	Manirakiza H, Shpinov Y, Gontier A, El H	ACS Sens	2026
A Constrained Degron Tag Engineered to Enhance Auxin-Inducible Protein Degradati [PMID:41941339]	Han Z, Alkhadrawi A, Tofani S, Zhang W,	ACS Synth Biol	2026
Bacterial DNA methylases as novel molecular and synthetic biology tools: recent [PMID:40047928]	Flores-Fernández CN, O'Callaghan CA	Applied microbiology and biote	2025
Rational multienzyme architecture design with iMARS. [PMID:39855196]	Wang J, Ouyang X, Meng S, Zhao B, Liu L,	Cell	2025
ZLN005 Alleviates the Dopaminergic Degeneration via PGC-1α-Mediated Mitochondria [PMID:41400900]	["Kaur J", "Naqvi S"]	Molecular neurobiology	2025
A synthetic protein-level neural network in mammalian cells. [PMID:39666795]	Chen Z, Linton JM, Xia S, Fan X, Yu D, W	Science (New York, N.Y.)	2024
Synthetic biology-based bacterial extracellular vesicles displaying BMP-2 and CX [PMID:38576241]	Liu H, Song P, Zhang H, Zhou F, Ji N, Wa	Journal of extracellular vesic	2024
Unstructured polypeptides as a versatile drug delivery technology. [PMID:37075961]	["Ji Y", "Liu D", "Zhu H", "Bao L", "Cha	Acta biomaterialia	2023
Harlequin syndrome associated with thoracic epidural anaesthesia. [PMID:35118419]	Persson RM, Tellnes K, Hoven H, Haaverst	Anaesthesia reports	2022
CPEB alteration and aberrant transcriptome-polyadenylation lead to a treatable S [PMID:34586830]	Picó S, Parras A, Santos-Galindo M, Pose	Sci Transl Med	2021
Transmission dynamics of a linear vanA-plasmid during a nosocomial multiclonal o [PMID:34285270]	Fujiya Y, Harada T, Sugawara Y, Akeda Y,	Scientific reports	2021
High resolution spatiotemporal patterns of seawater temperatures across the Beli [PMID:33199700]	Helmuth B, Leichter JJ, Rotjan RD, Casti	Scientific data	2020
Fat cadherins in mouse models of degenerative ataxias. [PMID:31695130]	["Baron O", "Grieshober D", "Dias C", "F	Scientific reports	2019
Dexamethasone Inhibits Copper-Induced Alpha-Synuclein Aggregation by a Metalloth [PMID:29064068]	["McLeary F", "Rcom-H'cheo-Gauthier A",	Neurotoxicity research	2018

MS

Understanding Entity Pages

Wiki Pages (20)

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Clinical Management Guide for CBS/PSP

Corticobasal Syndrome (CBS)

Novel Therapy Index

CBS/PSP Supplements Guide

Parthanatos in Neurodegeneration

Alpha-Synuclein Pathology

Therapeutics

NPM1 Gene

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

neuroinflammation

GRIA3 Gene

NRF2 Oxidative Stress Pathway

Microglial Cells — Cell Type Hierarchy

NTF4 Protein

TREM2 Mechanism Hub

HNRNPA2B1 Protein

CBS/PSP Clinical Trials Guide

CLCN10 — Chloride Voltage-Gated Channel 10

Pathway Diagram

Outgoing (513)

Incoming (5270)

Targeting Hypotheses (4)

Mentioning Analyses (30)

How does engineered C. butyricum cross the blood-brain barrier to directly bind

How does SYNGAP1, a 'synaptic' protein, function in pre-synaptic radial glia cel

What molecular mechanisms link elevated sphingomyelin synthase activity to incre

Why does PRKN-mediated mitophagy, typically protective, cause harmful mitochondr

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

How does pericyte senescence mechanistically promote glioma cell growth and inva

What are the molecular mechanisms by which GLP-1RAs provide neuroprotective effe

What molecular mechanisms determine whether reactive astrocytes adopt neurotoxic

What molecular mechanisms enable functional recovery and muscle re-innervation a

How do P/Q channel deficits paradoxically increase thalamic excitability despite

What molecular mechanisms drive neuron-to-glioma synapse formation in high-neura

How do the seven novel ALS genes function in animal models to cause neurodegener

What molecular mechanisms enable microglia to neutralize OxPC-mediated neurodege

What molecular mechanisms underlie Atremorine's dramatic dopamine enhancement in

How does PIKFYVE inhibition activate unconventional protein clearance via exocyt

How do B cells mechanistically orchestrate tolerance to AQP4 and prevent autoimm

What mechanisms explain how IDH1/IDH2 mutations with reduced enzymatic activity

Which tau PTMs are both disease-specific and druggable with selective small mole

What are the specific molecular mechanisms by which peripheral monocytes cross t

What determines the temporal transition from protective to pathological stress g

What are the molecular determinants that control directional mitochondrial trans

What specific gene expression signatures in aging mouse brain predict human AD v

Which neural cell types exhibit the most pronounced gene expression alterations

Which cell-type vulnerability signatures from SEA-AD single-cell data represent

Do migratory animals encode specific spatial locations epigenetically or rely on

Can circadian interventions selectively target microglia without affecting other

What evidence supports Cdk5 activation as THE primary cause of AD versus other e

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

Related Papers (20)