P38 MAPK

Understanding Entity Pages

This page aggregates everything SciDEX knows about P38 MAPK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

p38 MAPK is a stress-activated kinase (p38 alpha/beta/gamma/delta) regulating neuroinflammation, tau phosphorylation, and neuronal apoptosis in Alzheimer's and Parkinson's disease

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flowchart TD
    N0["P38 Mapk"]
    N1["P38"]
    N1 -->|"activates"| N0
    N2["INFLAMMATION"]
    N2 -->|"activates"| N0
    N3["Inflammation"]
    N3 -->|"activates"| N0
    N4["Neurodegeneration"]
    N0 -->|"involved in"| N4
    N5["ERK"]
    N5 -->|"activates"| N0
    N6["IL-6"]
    N6 -->|"activates"| N0
    N7["Als"]
    N7 -->|"activates"| N0
    N8["CANCER"]
    N8 -->|"activates"| N0
    N9["Tumor"]
    N9 -->|"activates"| N0
    N10["Cancer"]
    N10 -->|"activates"| N0
    N11["APOPTOSIS"]
    N11 -->|"activates"| N0
    N12["NEUROTOXICITY"]
    N12 -->|"activates"| N0
    N13["JNK"]
    N13 -->|"activates"| N0
    N14["CYTOKINES"]
    N14 -->|"activates"| N0
    N15["JUN"]
    N15 -->|"activates"| N0

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    class N2 gene
    class N3 disease
    class N5 gene
    class N6 gene
    class N7 disease
    class N8 gene
    class N9 disease
    class N10 disease
    class N11 gene
    class N12 gene
    class N13 gene
    class N14 gene
    class N15 gene