protein 643 words KG: GSTP1 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

GSTP1 Protein (Glutathione S-Transferase Pi 1)

🔬 Protein Info
Gene SymbolGSTP1
AliasesGlutathione S-Transferase Pi 1
Chromosome11q13.2
Protein FamilyPi class glutathione S-transferase family
Protein TypeEnzyme
Subcellular LocalizationCytoplasm, nucleus
Molecular Weight23 kDa
Amino Acids198 aa
PathwaysSignaling:** Interacts with TNF receptor, MAPK, NF-κB
UniProt IDGSTP1
Ensembl IDENSG00000042832
GeneCardsGSTP1
Human Protein AtlasGSTP1
Associated DiseasesALS, Alzheimer, Alzheimer'S Disease, Anxiety, Dementia
Known Drugs/CompoundsGalangin
InteractionsGAL, PTGS2, JUN, SLC7A11, NRF2, GPX4
KG Connections144 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (12)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Noradrenergic-Tau Propagation Blockade
Score: 0.51
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54

Related Analyses (8)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (11)

APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: associated_with
CYP3A4 — Cytochrome P450 3A4
gene · KG edge: associated_with
CYP2D6 — Cytochrome P450 2D6
gene · KG edge: associated_with
COMT Gene
gene · KG edge: associated_with
CHAT Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

GSTP1 associated_with CYP3A4
GSTP1 associated_with ABCG2
GSTP1 associated_with ADRB2
GSTP1 associated_with ABCB1
GSTP1 associated_with COMT
GSTP1 associated_with CHAT
GSTP1 associated_with HMGCR
GSTP1 associated_with OPRM1
GSTP1 associated_with MAOB
GSTP1 associated_with SLC6A3