gene

GAL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GAL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

290Connections

2Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

GAL is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, expressed in. Associated with Aging, Als, Alzheimer. Connected to 172 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	GAL
Chromosome	11q13.2
Function	The GAL gene encodes preprogalanin, which is processed to galanin (1-29) and galanin message-associated peptide (GMAP).
Amino Acids	30 aa
Pathways	Apoptosis, Hippo Pathway
Ensembl ID	ENSG00000178394
GeneCards	GAL
Human Protein Atlas	GAL
Associated Diseases	Aging, Alzheimer, Cancer, Ms, Rheumatoid Arthritis, Senescence
Interactions	PI3K, NRF2, AKT, TLR4, TREM2, NLRP3
KG Connections	290 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    GAL["GAL"]
    GAL -->|"activates"| Aging["Aging"]
    GAL -->|"activates"| Neurodegeneration["Neurodegeneration"]
    GAL -->|"activates"| Alzheimer["Alzheimer"]
    GAL -->|"inhibits"| Neuroinflammation["Neuroinflammation"]
    GAL -->|"inhibits"| Inflammation["Inflammation"]
    GAL -->|"activates"| Parkinson["Parkinson"]
    GAL -->|"activates"| Ms["Ms"]
    GAL -->|"interacts"| Cardiac["Cardiac"]
    GAL -->|"interacts"| Fibrosis["Fibrosis"]
    CAT["CAT"] -->|"expressed in"| GAL
    IL_6["IL-6"] -->|"regulates"| GAL
    GFAP["GFAP"] -->|"activates"| GAL
    ASTROCYTES["ASTROCYTES"] -->|"activates"| GAL
    GSTP1["GSTP1"] -->|"inhibits"| GAL
    AGING["AGING"] -->|"activates"| GAL
    MTOR["MTOR"] -->|"activates"| GAL
    FIP200["FIP200"] -->|"activates"| GAL

Outgoing (186)

Target	Relation	Type	Str
Aging	activates	disease	1.00
AGING	activates	gene	1.00
AKT	activates	gene	0.90
NRF2	activates	gene	0.80
Oxidative Stress	activates	pathway	0.80
Autophagy	activates	pathway	0.80
Ferroptosis	inhibits	pathway	0.80
Mtor	activates	pathway	0.80
Neurodegeneration	activates	disease	0.75
Als	activates	disease	0.75
Als	expressed_in	disease	0.75
Senescence	activates	disease	0.75
Cardiovascular	activates	disease	0.75
NRF2	inhibits	gene	0.70
MTOR	activates	gene	0.70
FERROPTOSIS	inhibits	gene	0.70
Mitochondrial Function	treats	pathway	0.70
P21	activates	gene	0.70
Oxidative Stress	inhibits	pathway	0.70
Apoptosis	inhibits	pathway	0.70
Pi3K/Akt	activates	pathway	0.70
Alzheimer	activates	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Parkinson	activates	disease	0.65
Ms	activates	disease	0.65
Inflammation	interacts_with	disease	0.65
Cardiac	interacts_with	disease	0.65
Fibrosis	interacts_with	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	activates	disease	0.65
Fibrosis	activates	disease	0.65
Senescence	regulates	disease	0.65
Aging	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Carcinoma	expressed_in	disease	0.65
Fibrosis	inhibits	disease	0.65
Cardiac	activates	disease	0.65
Cancer	inhibits	disease	0.65
Cancer	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Atherosclerosis	activates	disease	0.65
Sarcopenia	treats	disease	0.65
Als	treats	disease	0.65
Senescence	inhibits	disease	0.65
Als	inhibits	disease	0.65
Senescence	causes	disease	0.65
Inflammation	expressed_in	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Ischemia	treats	disease	0.65

Incoming (104)

Source	Relation	Type	Str
JNK	inhibits	gene	0.70
PI3K	activates	gene	0.70
P53	activates	gene	0.70
APOPTOSIS	inhibits	gene	0.70
OXIDATIVE STRESS	inhibits	gene	0.70
FERROPTOSIS	inhibits	gene	0.70
OXIDATIVE STRESS	activates	gene	0.70
AUTOPHAGY	activates	gene	0.70
CAT	expressed_in	gene	0.60
GFAP	activates	gene	0.60
GSTP1	inhibits	gene	0.60
MTOR	activates	gene	0.60
FIP200	activates	gene	0.60
PI3K	treats	gene	0.60
PSP	activates	gene	0.60
SIRT1	activates	gene	0.60
SPP1	inhibits	gene	0.60
TNF	expressed_in	gene	0.60
SLC7A11	inhibits	gene	0.60
GPX4	inhibits	gene	0.60
PTGS2	activates	gene	0.60
GPX4	activates	gene	0.60
RPS6KB1	activates	gene	0.60
JUN	activates	gene	0.60
NRF2	inhibits	gene	0.60
OPTINEURIN	associated_with	gene	0.60
CDKN1A	associated_with	gene	0.60
CDKN2A	associated_with	gene	0.60
NDP52	associated_with	gene	0.60
AKT	associated_with	gene	0.60
TNF	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
CALCOCO2	associated_with	gene	0.60
CXCL1	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
LC3	associated_with	gene	0.60
PINK1	associated_with	gene	0.60
BMAL1	associated_with	gene	0.60
CLOCK	regulates	gene	0.60
TAZ	regulates	gene	0.60
AKT	activates	gene	0.60
NRF2	activates	gene	0.60
ST3GAL2	expressed_in	gene	0.60
JUN	inhibits	gene	0.60
IL6	activates	gene	0.60
TNF	activates	gene	0.60
IL1B	activates	gene	0.60
BDNF	activates	gene	0.60
AGING	associated_with	gene	0.60
IL-6	regulates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Vagal Afferent Microbial Signal Modulation	0.521	neurodegeneration	What are the mechanisms by which gut mic
Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain A	0.512	neurodegeneration	What are the mechanisms by which gut mic

Mentioning Analyses (1)

Scientific analyses that reference this entity

What molecular mechanisms enable Gal3 to enhance tau fibrillation upon binding t

neurodegeneration | 2026-04-15 | 0 hypotheses

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
In Silico Pharmacogenomic Assessment of Glucagon-like Peptide-1 (GLP1) Agonists [PMID:39865816]	Sharafshah A, Lewandrowski KU, Gold MS,	Current neuropharmacology	2025	1
Chemogenetic inhibition of central amygdala CRF-expressing neurons decreases alc [PMID:38509197]	["Cruz B", "Vozella V", "Borgonetti V",	Molecular psychiatry	2024	1
Brainstem BDNF neurons are downstream of GFRAL/GLP1R signalling. [PMID:39737892]	["Feetham CH", "Collabolletta V", "Worth	Nature communications	2024	1
Astrocytic α7-nicotinic acetylcholine receptors mediate pain information process [PMID:41453579]	Teng T, Yang S, Li J, Wang H, Wu F, He Y	Neurobiology of disease	2026	0
Signal-Level Determinants of Cognitive Decline With PPIs versus H2RAs: Transport [PMID:41663888]	Saihati HAA, Ahmed BY, Mosaad RM, El-Gar	Molecular nutrition & food res	2026	0
Nicotine Suppresses Human Memory Th Cell Subsets With Preferential Effects on Ce [PMID:41928597]	Gholizadeh F, Hajiaghayi M, Rahbari N, C	Eur J Immunol	2026	0
Alpha 7 nicotinic acetylcholine receptor contributes to long-term cognitive reco [PMID:41270982]	Nguyen DT, Mendoza K, Hall C, Tan C, Cha	Experimental neurology	2026	0
Putative α7-selective ligands interact with α9-containing nicotinic acetylcholin [PMID:41890755]	Mobasher M, Hone AJ, Pilzecker M, Bozic	Frontiers in immunology	2026	0
Short-term exposure to a high-fat diet leads to neuroinflammation and impairs me [PMID:41565126]	Costa SO, Silva IM, Chaves WF, Esteves A	The Journal of nutritional bio	2026	0
Acetylcholine enhances HIF-1α signaling in pancreatic cancer cells under hypoxia [PMID:41608625]	Cho Y, Kim HG, Kang JH, Oh ET, Park HJ	International journal of biolo	2026	0
The microbiome and eating disorders: a new framework at the interface of interoc [PMID:41921818]	["Ziade I", "McDermott M", "O'Riordan K"	Neuroscience	2026	0
Central-peripheral neuroimmune dynamics in psychological stress and depression: [PMID:40610703]	Feng X, Jia M, Cai M, Zhu T, Hashimoto K	Molecular psychiatry	2025	0
The ATP-mediated cytokine release by macrophages is down-modulated by unconventi [PMID:41221292]	Wolf PMK, Hanke D, Singh VK, Keller HL,	Frontiers in immunology	2025	0
Liraglutide Attenuates Atorvastatin-Induced Hepatotoxicity by Restoring GLP-1R E [PMID:40711038]	["Elsiad E", "Abd El Aal H", "Salem H",	Toxics	2025	0
Splenic nerve denervation attenuates depression-like behaviors in Chrna7 knock-o [PMID:38944290]	["Yang Y", "Eguchi A", "Mori C", "Hashim	Journal of affective disorders	2024	0
Vagus nerve stimulation as a promising neuroprotection for ischemic stroke via α [PMID:38504011]	Xia XM, Duan Y, Wang YP, Han RX, Dong YF	Acta pharmacologica Sinica	2024	0
The potential role of Tirzepatide as adjuvant therapy in countering colistin-ind [PMID:38788447]	["Hassan N", "Ragab D", "Ibrahim S", "Ab	International immunopharmacolo	2024	0
The effects of Fc fusion protein glucagon-like peptide-1 and glucagon dual recep [PMID:38518602]	["Jiang P", "Zeng Y", "Yang W", "Li L",	Biomedicine & pharmacotherapy	2024	0
Comparative effects of glucagon-like peptide-1 receptor agonists and sodium-gluc [PMID:39217337]	["Albulushi A", "Tanoh D", "Almustafa A"	Cardiovascular diabetology	2024	0
A role of gut-microbiota-brain axis via subdiaphragmatic vagus nerve in depressi [PMID:36191806]	["Yang Y", "Eguchi A", "Wan X", "Chang L	Progress in neuro-psychopharma	2023	0

GAL

Understanding Entity Pages

Summary

Wiki Pages (21)

GAL Gene

Idorsia Pharmaceuticals Ltd.

Microglial Senescence Pathway in Neurodegeneration

Cellular Senescence in Neurodegeneration

Aging vs Neurodegeneration: Mechanistic Comparison Matrix

Cellular Senescence in Neurodegeneration

ALS Combination Therapy Matrix

Senolytic Therapies for CBS and [PSP](/diseases/progressive-supranuclear-palsy)

Arcuate Nucleus POMC Neurons

fabry-disease

Astrocyte Senescence Pathway in Neurodegeneration

Fabry Disease Pathway

slc22a1

tdp-43-fus-rna-proteinopathy-comparison

CBS Microglial Neuroimmune Axis

Microglia and neuroinflammation in Alzheimer's Disease

Cellular Senescence Hypothesis in Parkinson's Disease

Cellular Senescence in Corticobasal Syndrome

Section 135: Telomere Biology and Anti-Aging Interventions in CBS/PSP

Cellular Senescence in Brain Aging and Neurodegeneration