protein

UFL1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about UFL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

46Connections

0Hypotheses

0Analyses

27Outgoing

19Incoming

Summary

UFL1 is a crucial enzyme in the UFM1ylation pathway, a ubiquitin-like modification system essential for ER function, calcium homeostasis, and neurological health. Mutations in UFL1 are linked to hereditary spastic paraplegia and other neurodegenerative co

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🔬 Protein Info

Gene Symbol	UFL1
Molecular Weight	39 kDa
Amino Acids	346 aa
Pathways	Nf-Κb, NF-kB signaling, ubiquitin-proteasome
GeneCards	UFL1
Human Protein Atlas	UFL1
Associated Diseases	ALS, dementia, frontotemporal
Interactions	PARP1, LRP1, Ubiquitin, App, UFM1, VCP
KG Connections	46 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (6)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    UFL1["UFL1"]
    UFL1 -->|"phosphorylates"| PARP1["PARP1"]
    UFL1 -->|"activates"| Tumor["Tumor"]
    UFL1 -->|"activates"| Carcinoma["Carcinoma"]
    UFL1 -->|"activates"| Nf__b["Nf-Kappab"]
    UFL1 -->|"activates"| LRP1["LRP1"]
    UFL1 -->|"activates"| Ubiquitin["Ubiquitin"]
    UFL1 -->|"activates"| App["App"]
    UFL1 -->|"activates"| CARCINOMA["CARCINOMA"]
    NF__B["NF-KappaB"] -->|"activates"| UFL1
    LRP1 -->|"activates"| UFL1
    UBIQUITIN["UBIQUITIN"] -->|"activates"| UFL1
    AND["AND"] -->|"activates"| UFL1

Outgoing (27)

Target	Relation	Type	Str
VCP	modulates	gene	0.95
PARP1	phosphorylates	protein	0.85
Tumor	activates	disease	0.65
Carcinoma	activates	disease	0.65
Nf-Κb	activates	pathway	0.60
LRP1	activates	gene	0.60
Ubiquitin	activates	protein	0.60
App	activates	protein	0.60
NF-kB signaling	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
ALS	associated_with	disease	0.60
dementia	associated_with	disease	0.60
frontotemporal	associated_with	disease	0.60
UFM1	activates	gene	0.60
VCP	activates	gene	0.60
autophagy pathway	participates_in	pathway	0.60
UVRAG	activates	gene	0.60
ALS	activates	disease	0.60
frontotemporal dementia	activates	disease	0.60
oxidative stress response	participates_in	pathway	0.60
CARCINOMA	activates	disease	0.50
NF-κB	activates	concept	0.50
HEPATOCELLULAR CARCINOMA	activates	disease	0.50
GENE EXPRESSION	activates	concept	0.50
NF-κB	interacts_with	concept	0.50
UFM1	co_expressed_with	gene	0.50
UVRAG	co_expressed_with	gene	0.50

Incoming (19)

Source	Relation	Type	Str
NF-ΚB	activates	gene	0.60
LRP1	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
AND	activates	gene	0.60
BECN1	activates	gene	0.60
ATG14	activates	gene	0.60
LC3B	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
NPL4	activates	gene	0.60
PIK3C3	activates	gene	0.60
RPL26	activates	gene	0.60
RPN1	activates	gene	0.60
SQSTM1	activates	gene	0.60
UFD1	activates	gene	0.60
LRP1	associated_with	gene	0.60
MEF2D	associated_with	gene	0.60
STAT6	associated_with	gene	0.60
SQSTM1	co_expressed_with	gene	0.50
UFD1	co_expressed_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

UFL1

Understanding Entity Pages

Summary

Wiki Pages (6)

UFL1 Protein (UFM1-Specific Protease 1)

MEF2D — Myocyte Enhancer Factor 2D

UFM1ylation Modulation Therapy for Neurodegeneration

ULF1 Gene