Layer-Specific Excitatory Neuron Vulnerability in Temporal Cortex

graph TD
    MMP9["MMP9"] -->|causes| BBB_breakdown["BBB breakdown"]
    MMP9_1["MMP9"] -->|causes| Tau_Propagation["Tau Propagation"]
    Vascular_Dysfunction["Vascular Dysfunction"] -->|causes| Tau_Propagation_2["Tau Propagation"]
    CSF1R["CSF1R"] -->|regulates| neuroinflammation["neuroinflammation"]
    apoe4["apoe4"] -->|causes| microglial_inflammation["microglial inflammation"]
    TREM2_deficiency["TREM2 deficiency"] -->|causes| alternative_DAM_activatio["alternative DAM activation"]
    ER_Stress["ER Stress"] -->|causes| Neuronal_Vulnerability["Neuronal Vulnerability"]
    EIF2AK3["EIF2AK3"] -->|regulates| UNFOLDED_PROTEIN_RESPONSE["UNFOLDED PROTEIN RESPONSE"]
    mitochondrial_dysfunction["mitochondrial_dysfunction"] -->|causes| Neuronal_Vulnerability_3["Neuronal Vulnerability"]
    PDGFRA["PDGFRA"] -->|causes| OPC_maturation_arrest["OPC maturation arrest"]
    OPC_maturation_arrest_4["OPC maturation arrest"] -->|causes| Demyelination["Demyelination"]
    TDP_43["TDP-43"] -->|associated with| AD_TDP_co_pathology["AD-TDP co-pathology"]
    style MMP9 fill:#ce93d8,stroke:#333,color:#000
    style BBB_breakdown fill:#4fc3f7,stroke:#333,color:#000
    style MMP9_1 fill:#ce93d8,stroke:#333,color:#000
    style Tau_Propagation fill:#4fc3f7,stroke:#333,color:#000
    style Vascular_Dysfunction fill:#4fc3f7,stroke:#333,color:#000
    style Tau_Propagation_2 fill:#4fc3f7,stroke:#333,color:#000
    style CSF1R fill:#ce93d8,stroke:#333,color:#000
    style neuroinflammation fill:#4fc3f7,stroke:#333,color:#000
    style apoe4 fill:#ef5350,stroke:#333,color:#000
    style microglial_inflammation fill:#4fc3f7,stroke:#333,color:#000
    style TREM2_deficiency fill:#4fc3f7,stroke:#333,color:#000
    style alternative_DAM_activatio fill:#4fc3f7,stroke:#333,color:#000
    style ER_Stress fill:#4fc3f7,stroke:#333,color:#000
    style Neuronal_Vulnerability fill:#4fc3f7,stroke:#333,color:#000
    style EIF2AK3 fill:#ce93d8,stroke:#333,color:#000
    style UNFOLDED_PROTEIN_RESPONSE fill:#ce93d8,stroke:#333,color:#000
    style mitochondrial_dysfunction fill:#4fc3f7,stroke:#333,color:#000
    style Neuronal_Vulnerability_3 fill:#4fc3f7,stroke:#333,color:#000
    style PDGFRA fill:#ce93d8,stroke:#333,color:#000
    style OPC_maturation_arrest fill:#4fc3f7,stroke:#333,color:#000
    style OPC_maturation_arrest_4 fill:#4fc3f7,stroke:#333,color:#000
    style Demyelination fill:#81c784,stroke:#333,color:#000
    style TDP_43 fill:#4fc3f7,stroke:#333,color:#000
    style AD_TDP_co_pathology fill:#ef5350,stroke:#333,color:#000