Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CNTF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CNTF is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, inhibits, associated with. Associated with Autoimmune, Cancer, Infection. Connected to 12 entities in the SciDEX knowledge graph.
| Gene Symbol | CNTF |
| Full Name | Ciliary Neurotrophic Factor |
| Chromosome | 11q13.1 |
| Protein Family | IL-6 family of cytokines |
| Function | is a neuroprotective cytokine belonging to the interleukin-6 (IL-6) family of cytokines. |
| Primary Expression | astrocytes throughout the brain and spinal cord - Peripheral nervous system: Expressed in Schwann cells and olfactory ensh |
| Molecular Weight | 22.7 kDa |
| Amino Acids | 200 aa |
| Gene Type | Protein-coding gene |
| Pathways | JAK-STAT signaling, MAPK Pathway, PI3K, MAPK |
| UniProt ID | P26441 |
| NCBI Gene ID | 1270 |
| Ensembl ID | ENSG00000261349 |
| OMIM | 118425 |
| GeneCards | CNTF |
| Human Protein Atlas | CNTF |
| Associated Diseases | ALS, Alzheimer's disease, Parkinson's disease |
| Known Drugs/Compounds | metformin |
| Interactions | LIF, GDNF, MBP, MOG, NGF, GSDMD |
| KG Connections | 38 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CNTF["CNTF"]
GDNF["GDNF"]
CNTF -->|"associated_with"| GDNF
Autoimmune{"Autoimmune"}
CNTF -->|"therapeutic_target"| Autoimmune
Cancer{"Cancer"}
CNTF -->|"therapeutic_target"| Cancer
Infection{"Infection"}
CNTF -->|"therapeutic_target"| Infection
Inflammation{"Inflammation"}
CNTF -->|"therapeutic_target"| Inflammation
BDNF["BDNF"]
BDNF -->|"associated_with"| CNTF
CANCER["CANCER"]
CNTF -->|"therapeutic_target"| CANCER
AND["AND"]
CNTF -->|"inhibits"| AND
CYTOKINES["CYTOKINES"]
CNTF -->|"inhibits"| CYTOKINES
LIF["LIF"]
CNTF -->|"inhibits"| LIF
IL_6["IL-6"]
CNTF -->|"inhibits"| IL_6
LIF -->|"inhibits"| CNTF
CYTOKINES -->|"inhibits"| CNTF
IL_6 -->|"inhibits"| CNTF
INFLAMMATION["INFLAMMATION"]
INFLAMMATION -->|"therapeutic_target"| CNTF| Target | Relation | Type | Str |
|---|---|---|---|
| GDNF | associated_with | gene | 0.65 |
| Autoimmune | therapeutic_target | disease | 0.65 |
| Cancer | therapeutic_target | disease | 0.65 |
| Infection | therapeutic_target | disease | 0.65 |
| Inflammation | therapeutic_target | disease | 0.65 |
| Epilepsy | activates | disease | 0.65 |
| LIF | inhibits | gene | 0.60 |
| Schwann Cell | transports | cell_type | 0.60 |
| Cntf | transports | protein | 0.60 |
| MBP | activates | gene | 0.60 |
| MOG | activates | gene | 0.60 |
| NGF | activates | gene | 0.60 |
| GSDMD | inhibits | gene | 0.60 |
| GDNF | protects_against | gene | 0.60 |
| NGF | associated_with | gene | 0.60 |
| CANCER | therapeutic_target | gene | 0.60 |
| AND | inhibits | gene | 0.60 |
| CYTOKINES | inhibits | gene | 0.60 |
| IL-6 | inhibits | gene | 0.60 |
| ASTROCYTES | transports | gene | 0.60 |
| ASTROCYTE | transports | gene | 0.60 |
| EPILEPSY | activates | gene | 0.60 |
| Astrocyte | transports | cell_type | 0.60 |
| Neuron | transports | cell_type | 0.60 |
| Cytokine | transports | protein | 0.60 |
| FGF | associated_with | gene | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| GDNF | activates | gene | 0.55 |
| neurotrophin signaling | participates_in | pathway | 0.55 |
| microglia | expressed_in | cell_type | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||