concept

FGF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FGF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

466Connections

0Hypotheses

0Analyses

50Outgoing

48Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	AD FGF/FGFR Signaling Companies
Summary	Category page for companies developing Fibroblast Growth Factor (FGF) and FGFR signaling therapies for Alzheimer's disease
Key Genes/Proteins	MTOR
Related Diseases	Cancer, Neurodegeneration, Alzheimer, Neuroinflammation, Inflammation
Related Pathways	oxidative stress response, TGF-beta signaling

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    FGF["FGF"]
    style FGF fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    FGF -->|"regulates"| MTOR([MTOR])
    FGF -->|"regulates"| MYELINATION["MYELINATION"]
    FGF -->|"expressed in"| Cancer["Cancer"]
    FGF -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    FGF -->|"regulates"| Alzheimer["Alzheimer"]
    FGF -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    FGF -->|"regulates"| Inflammation["Inflammation"]
    DNA([DNA]) -->|"activates"| FGF
    FGF1([FGF1]) -->|"interacts"| FGF
    ERK1_2([ERK1/2]) -->|"activates"| FGF
    NEURODEGENERATION([NEURODEGENERATION]) -->|"regulates"| FGF
    EXERCISE([EXERCISE]) -->|"regulates"| FGF
    NEUROINFLAMMATION([NEUROINFLAMMATION]) -->|"regulates"| FGF
    MITOCHONDRIAL_DYSFUNCTION([MITOCHONDRIAL DYSFUNCTION]) -->|"regulates"| FGF
    ASTROCYTE([ASTROCYTE]) -->|"regulates"| FGF
    ALZHEIMER([ALZHEIMER]) -->|"regulates"| FGF
    FGF2([FGF2]) -->|"interacts"| FGF

Outgoing (201)

Target	Relation	Type	Str
oxidative stress response	participates_in	pathway	0.70
astrocytes	expressed_in	cell_type	0.70
TGF-beta signaling	participates_in	pathway	0.70
MTOR	regulates	gene	0.65
Cancer	expressed_in	disease	0.65
Neurodegeneration	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Glioblastoma	associated_with	disease	0.65
Neurodegeneration	activates	disease	0.65
Traumatic Brain Injury	activates	disease	0.65
ALS	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Parkinson	activates	disease	0.65
Inflammation	activates	disease	0.65
Fibrosis	activates	disease	0.65
Cancer	activates	disease	0.65
Aging	therapeutic_target	disease	0.65
AND	interacts_with	gene	0.60
CANCER	expressed_in	gene	0.60
FGF2	interacts_with	gene	0.60
ERK1	activates	gene	0.60
Angiogenesis	inhibits	pathway	0.60
MANF	regulates	gene	0.60
AND	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
AMYLOID	regulates	gene	0.60
TAU	regulates	gene	0.60
Oxidative Stress	regulates	pathway	0.60
Immune Response	regulates	pathway	0.60
Amyloid	regulates	pathway	0.60
Lipid Metabolism	regulates	pathway	0.60
Endothelial	activates	cell_type	0.60
Stem Cell	contributes_to	cell_type	0.60
Fibroblast	interacts_with	cell_type	0.60
Fibroblast	regulates	cell_type	0.60
Astrocyte	regulates	cell_type	0.60
Apoptosis	causes	pathway	0.60
EGFR	inhibits	gene	0.60
GLIOBLASTOMA	associated_with	gene	0.60
Fibroblast	inhibits	cell_type	0.60
APOPTOSIS	causes	gene	0.60
GENES	causes	gene	0.60
AND	causes	gene	0.60
Tgf-Β	causes	pathway	0.60
PSD95	activates	gene	0.60

Incoming (265)

Source	Relation	Type	Str
DNA	activates	gene	0.60
FGF1	interacts_with	gene	0.60
ERK1/2	activates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
EXERCISE	regulates	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.60
ASTROCYTE	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
FGF2	interacts_with	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
TAU	therapeutic_target	gene	0.60
MANF	regulates	gene	0.60
EXERCISE	therapeutic_target	gene	0.60
APOPTOSIS	causes	gene	0.60
EGF	activates	gene	0.60
GBM	associated_with	gene	0.60
FGFR1	inhibits	gene	0.60
SYNAPSE	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
PARKINSON	activates	gene	0.60
SPTLC1	activates	gene	0.60
CANCER	expressed_in	gene	0.60
ERK1	activates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
FGFR2	inhibits	gene	0.60
B3GALT6	activates	gene	0.60
FGFR2	expressed_in	gene	0.60
CCL5	regulates	gene	0.60
EGF	associated_with	gene	0.60
ALS	biomarker_for	gene	0.60
C3	biomarker_for	gene	0.60
ALS	regulates	gene	0.60
C3	regulates	gene	0.60
ALS	associated_with	gene	0.60
CNTF	associated_with	gene	0.60
CTGF	associated_with	gene	0.60
BDNF	associated_with	gene	0.55
ALZHEIMER'S DISEASE	associated_with	disease	0.48
AMYLOID	associated_with	protein	0.48
TAU	associated_with	protein	0.48
MTOR	regulates	gene	0.48
ASTROCYTES	associated_with	cell_type	0.48
PARKINSON'S DISEASE	associated_with	disease	0.48
ASTROCYTE	co_discussed	cell_type	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

FGF

Understanding Entity Pages

Wiki Pages (21)

AD FGF/FGFR Signaling Companies

cbs-psp-daily-action-plan

Progressive Supranuclear Palsy (PSP)

nct07165106

Growth Factor Therapies

VEGF/Angiogenesis Pathway in Neurodegeneration

Mitochondrial Dysfunction in Neurodegeneration

Growth Factor Therapeutics: Investment Landscape Analysis

IGF-1 Signaling Pathway in Neurodegeneration

GBA1→GCase→Lysosome→PD Causal Chain

Notch Signaling Pathway in Neurodegeneration

FGF10 — Fibroblast Growth Factor 10

Neurogenesis

Oligodendrocyte and Myelin Dysfunction in Corticobasal Syndrome

Neurogenesis and Neurodegeneration

HRAS (Harvey Rat Sarcoma Viral Oncogene Homolog)

Alzheimer's Disease Synaptic Repair and Neuroprotection Companies

Neurotrophic Factors in Neurodegeneration

PTCH2 Gene