concept

FGF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FGF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

510Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	FGF
Key Genes/Proteins	Actin, Akt, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, Amyloid
Related Diseases	Aging, ALS, Alzheimer
Related Pathways	Angiogenesis, Apoptosis, apoptosis pathway

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    FGF["FGF"]
    style FGF fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    FGF -->|"regulates"| MTOR([MTOR])
    FGF -->|"regulates"| MYELINATION["MYELINATION"]
    FGF -->|"expressed in"| Cancer["Cancer"]
    FGF -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    FGF -->|"regulates"| Alzheimer["Alzheimer"]
    FGF -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    FGF -->|"regulates"| Inflammation["Inflammation"]
    DNA([DNA]) -->|"activates"| FGF
    FGF1([FGF1]) -->|"interacts"| FGF
    ERK1_2([ERK1/2]) -->|"activates"| FGF
    NEURODEGENERATION([NEURODEGENERATION]) -->|"regulates"| FGF
    EXERCISE([EXERCISE]) -->|"regulates"| FGF
    NEUROINFLAMMATION([NEUROINFLAMMATION]) -->|"regulates"| FGF
    MITOCHONDRIAL_DYSFUNCTION([MITOCHONDRIAL DYSFUNCTION]) -->|"regulates"| FGF
    ASTROCYTE([ASTROCYTE]) -->|"regulates"| FGF
    ALZHEIMER([ALZHEIMER]) -->|"regulates"| FGF
    FGF2([FGF2]) -->|"interacts"| FGF

Outgoing (229)

Target	Relation	Type	Str
SOD1	activates	gene	0.70
NEURONS	transports	cell_type	0.70
TFEB	activates	gene	0.70
SQSTM1	activates	gene	0.70
SOD2	activates	gene	0.70
SIRT1	activates	gene	0.70
ULK1	activates	gene	0.70
astrocytes	expressed_in	cell_type	0.70
oxidative stress response	participates_in	pathway	0.70
TGF-beta signaling	participates_in	pathway	0.70
Glioblastoma	associated_with	disease	0.65
Cancer	activates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Aging	therapeutic_target	disease	0.65
Inflammation	activates	disease	0.65
Parkinson	activates	disease	0.65
MTOR	regulates	gene	0.65
Cancer	expressed_in	disease	0.65
Fibrosis	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Traumatic Brain Injury	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
ALS	activates	disease	0.65
MTOR	associated_with	gene	0.60
NEURON	activates	gene	0.60
SYNAPTOPHYSIN	activates	gene	0.60
REELIN	activates	gene	0.60
CCL5	associated_with	gene	0.60
Myelination	associated_with	pathway	0.60
Mtor	associated_with	pathway	0.60
Neuroinflammation	biomarker_for	disease	0.60
Neurodegeneration	biomarker_for	disease	0.60
Alzheimer	biomarker_for	disease	0.60
Cancer	associated_with	disease	0.60
Obesity	contributes_to	disease	0.60
Aging	contributes_to	disease	0.60
oligodendrocytes	expressed_in	cell_type	0.60
lipid metabolism	participates_in	pathway	0.60
NEURON	co_discussed	cell_type	0.60
Fibroblast	regulates	cell_type	0.60
Astrocyte	regulates	cell_type	0.60
PSD95	activates	gene	0.60
BRAIN INJURY	associated_with	gene	0.60
CCR5	activates	gene	0.60

Incoming (281)

Source	Relation	Type	Str
ASTROCYTE	transports	cell_type	0.70
ATG5	interacts_with	gene	0.70
ATG7	interacts_with	gene	0.70
PPAR	activates	gene	0.60
FGF21	activates	gene	0.60
ULK1	activates	gene	0.60
LC3	activates	gene	0.60
ATGL	activates	gene	0.60
ATG7	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
PLAU	activates	gene	0.60
S100B	biomarker_for	gene	0.60
GPNMB	biomarker_for	gene	0.60
CX3CL1	activates	gene	0.60
APP	biomarker_for	gene	0.60
BDNF	activates	gene	0.60
MITOCHONDRIA	biomarker_for	gene	0.60
VIM	activates	gene	0.60
HMGB1	biomarker_for	gene	0.60
IGF-1	biomarker_for	gene	0.60
APOPTOSIS	biomarker_for	gene	0.60
FGF23	activates	gene	0.60
IL-6	activates	gene	0.60
PGRN	activates	gene	0.60
AMYLOID	biomarker_for	gene	0.60
CXCL10	activates	gene	0.60
AGING	biomarker_for	gene	0.60
GHRL	biomarker_for	gene	0.60
VIMENTIN	activates	gene	0.60
FNDC5	activates	gene	0.60
COMPLEMENT	biomarker_for	gene	0.60
PROGRANULIN	activates	gene	0.60
TGM2	biomarker_for	gene	0.60
CATHEPSIN-B	activates	gene	0.60
CYTOKINES	activates	gene	0.60
IGF-1	activates	gene	0.60
AGING	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
NCAM2	activates	gene	0.60
RORB	activates	gene	0.60
KCNIP4	activates	gene	0.60
FGF14	activates	gene	0.60
GRIN2A	activates	gene	0.60
NRXN1	activates	gene	0.60
APP	activates	gene	0.60
NLGN1	activates	gene	0.60
RORA	activates	gene	0.60
RHOA	activates	gene	0.60
GIT1	associated_with	gene	0.60
RAS	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FGF in their description or question text

No additional research found

FGF

Understanding Entity Pages

Wiki Pages (21)

Neural Precursor Development

FGF10 — Fibroblast Growth Factor 10

FGF23 — Fibroblast Growth Factor 23

FGF Signaling Pathway in Neurodegeneration

FGF7 — Fibroblast Growth Factor 7

FGF Signaling in Parkinson's Disease

FGF6 Gene

FGF8 Gene

FGF21 — Fibroblast Growth Factor 21

FGF16 Gene

FGF13-MTCH2 Neuroprotection in Parkinson's Disease

FGF4 — Fibroblast Growth Factor 4

FGF-2 Protein (bFGF)

AD FGF/FGFR Signaling Companies

FGF17 Protein

FGFR3 - Fibroblast Growth Factor Receptor 3

PD FGF/FGFR Signaling Companies

FGF13 — Fibroblast Growth Factor 13

Fibroblast Growth Factor 21 (FGF21)

FGF14 — Fibroblast Growth Factor 14

FGF19 — Fibroblast Growth Factor 19