process

Gut Microbiome

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Gut Microbiome: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

284Connections

1Hypotheses

5Analyses

24Outgoing

50Incoming

No summary available yet. View on Wiki →

🧬 Biological Process Info

Name	Gut Microbiome
Key Genes/Proteins	INFLAMMATION
Related Diseases	Neurodegenerative Diseases, Neurological Disorders, Parkinson'S Disease, Als, Inflammation
Linked Hypotheses	2 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Gut_Microbiome["<b>Gut Microbiome</b>"]
    Neurodegeneration_Progression["Neurodegeneration Progression"]
    Gut_Microbiome -->|"modulates"| Neurodegeneration_Progression
    Als{"Als"}
    Als -->|"activates"| Gut_Microbiome
    INFLAMMATION(["INFLAMMATION"])
    INFLAMMATION -->|"activates"| Gut_Microbiome
    Inflammation{"Inflammation"}
    Inflammation -->|"activates"| Gut_Microbiome
    style Gut_Microbiome fill:#1a3a4a,stroke:#90a4ae,stroke-width:3px,color:#e0e0e0

Outgoing (28)

Target	Relation	Type	Str
Short-Chain Fatty Acids	product_of	compound	0.95
Short-Chain Fatty Acids	associated_with	compound	0.95
Brain	interacts_with	brain_region	0.95
Neurodegenerative Diseases	contributes_to	disease	0.95
Neurological Disorders	associated_with	disease	0.90
Parkinson'S Disease	modulates	disease	0.90
Immune Dysregulation	contributes_to	process	0.85
Parkinson'S Disease	associated_with	disease	0.85
Neurodegenerative Disorders	associated_with	disease	0.85
Brain	mediates	brain_region	0.85
Neurodegeneration Progression	modulates	phenotype	0.75
Neurodegeneration	modulates	process	0.70
Alzheimer'S Disease	associated_with	disease	0.70
Neurodegeneration	correlates_with	process	0.70
CENTRAL NERVOUS SYSTEM	associated_with	concept	0.50
CHRONIC INFLAMMATION	interacts_with	concept	0.50
Pain	interacts_with	disease	0.50
SYNUCLEIN	associated_with	concept	0.50
SYNUCLEIN	interacts_with	concept	0.50
SYNUCLEIN	activates	concept	0.50
Telomere	activates	pathway	0.50
Reactive Oxygen Species	activates	process	0.50
CYTOKINE	regulates	concept	0.50
Proteins	associated_with	protein	0.50

Incoming (256)

Source	Relation	Type	Str
SDA-2026-04-01-gap-20260401-225155	investigates	analysis	0.95
Circadian Rhythm	regulates	process	0.90
Als	activates	disease	0.90
INFLAMMATION	activates	gene	0.90
Inflammation	activates	disease	0.90
INFLAMMATION	associated_with	gene	0.90
Inflammation	associated_with	disease	0.90
Als	therapeutic_target	disease	0.90
INFLAMMATION	regulates	gene	0.80
Inflammation	regulates	disease	0.80
INFLAMMATION	therapeutic_target	gene	0.80
Inflammation	therapeutic_target	disease	0.80
PARKINSON	associated_with	gene	0.80
Parkinson	associated_with	disease	0.80
Cancer	therapeutic_target	disease	0.80
ALZHEIMER	associated_with	gene	0.80
Alzheimer	associated_with	disease	0.80
Cardiovascular	therapeutic_target	disease	0.70
NEURODEGENERATION	activates	gene	0.70
Neurodegeneration	activates	disease	0.70
PARKINSON'S DISEASE	associated_with	gene	0.70
NEUROINFLAMMATION	activates	gene	0.70
MICROGLIA	activates	gene	0.70
Neuroinflammation	activates	disease	0.70
Als	causes	disease	0.70
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.70
Aging	therapeutic_target	disease	0.70
Als	associated_with	disease	0.70
ALZHEIMER'S DISEASE	associated_with	gene	0.70
CANCER	therapeutic_target	gene	0.70
CANCER	regulates	gene	0.60
CYTOKINES	regulates	gene	0.60
Tumor	regulates	disease	0.60
Colorectal Cancer	regulates	disease	0.60
Cancer	regulates	disease	0.60
PI3K	activates	gene	0.60
IL-6	activates	gene	0.60
LDL	activates	gene	0.60
GENES	activates	gene	0.60
AKT	activates	gene	0.60
JAK	activates	gene	0.60
Obesity	activates	disease	0.60
Nafld	activates	disease	0.60
PARKINSON'S DISEASE	activates	gene	0.60
CYTOKINES	activates	gene	0.60
PARKINSON	activates	gene	0.60
ALPHA-SYNUCLEIN	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
CD4	activates	gene	0.60
Parkinson	activates	disease	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming	0.607	neurodegeneration	What are the mechanisms by which gut mic

Mentioning Analyses (5)

Scientific analyses that reference this entity

Systemic immune profiling and peripheral immune contributions to neurodegenerati

neurodegeneration | 2026-04-04 | 0 hypotheses

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 0 hypotheses

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 0 hypotheses

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 20 hypotheses Top: 0.617

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 0 hypotheses

Related Papers (6)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
USP22 suppresses the NLRP3 inflammasome by degrading NLRP3 via ATG5-dependent au [PMID:35900990]	["Di Q", "Zhao X", "Tang H", "Li X", "Xi	Autophagy	2023	1
Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiqui [PMID:30966861]	["Han X", "Sun S", "Sun Y", "Song Q", "Z	Autophagy	2020	1
Nlrc4 Inflammasome Expression After Acute Myocardial Infarction in Rats. [PMID:40332346]	Borim PA, Gatto M, Mota GAF, Meirelles A	Int J Mol Sci	2025	0
Berberine Protects Against NLRP3 Inflammasome via Ameliorating Autophagic Impair [PMID:33584302]	Huang S, Liu H, Lin Y, Liu M, Li Y et al	Front Pharmacol	2020	0
Inflammasome and toll-like receptor signaling in human monocytes after successfu [PMID:27260481]	Asmussen A, Fink K, Busch HJ, Helbing T,	Crit Care	2016	0
Small molecule-driven mitophagy-mediated NLRP3 inflammasome inhibition is respon [PMID:24879148]	Guo W, Sun Y, Liu W, Wu X, Guo L et al.	Autophagy	2014	0

Gut Microbiome

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Clinical Management Guide for CBS/PSP

Novel Therapy Index

Parkinson's Disease

CBS/PSP Supplements Guide

Device Therapies Comparison for CBS/PSP

CBS/PSP Rehabilitation Master Guide

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Therapeutics

CBS/PSP Treatment Rankings

nct07165106

PD Cure Roadmap

TREM2 Mechanism Hub

Mitochondrial Dysfunction in Parkinson's Disease

Mitophagy Pathway in Neurodegeneration

gabaergic-dysfunction

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

Vitamin D Signaling Pathway in Neurodegeneration

rankings

Pathway Diagram

Outgoing (28)

Incoming (256)

Targeting Hypotheses (1)

Mentioning Analyses (5)

Systemic immune profiling and peripheral immune contributions to neurodegenerati

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

Related Papers (6)