DIABLO

Understanding Entity Pages

This page aggregates everything SciDEX knows about DIABLO: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Second Mitochondria-Derived Activator of Caspases (SMAC) - pro-apoptotic mitochondrial protein with key roles in neurodegeneration

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graph TD
    DIABLO["<b>DIABLO</b>"]
    Als{"Als"}
    DIABLO -->|"activates"| Als
    Ms{"Ms"}
    DIABLO -->|"interacts with"| Ms
    DIABLO -->|"regulates"| Ms
    Stroke{"Stroke"}
    DIABLO -->|"regulates"| Stroke
    Neurodegeneration{"Neurodegeneration"}
    DIABLO -->|"regulates"| Neurodegeneration
    APOPTOSIS["APOPTOSIS"]
    DIABLO -->|"activates"| APOPTOSIS
    AUTOPHAGY["AUTOPHAGY"]
    DIABLO -->|"activates"| AUTOPHAGY
    HTRA2["HTRA2"]
    DIABLO -->|"activates"| HTRA2
    SMAC["SMAC"]
    DIABLO -->|"interacts with"| SMAC
    LC3["LC3"]
    DIABLO -->|"activates"| LC3
    Apoptosis(["Apoptosis"])
    DIABLO -->|"activates"| Apoptosis
    Autophagy(["Autophagy"])
    DIABLO -->|"activates"| Autophagy
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"interacts with"| DIABLO
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"regulates"| DIABLO
    E2F1["E2F1"]
    E2F1 -->|"regulates"| DIABLO
    P53["P53"]
    P53 -->|"regulates"| DIABLO
    MYC["MYC"]
    MYC -->|"regulates"| DIABLO
    style DIABLO fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0