concept

NRF2 PATHWAY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NRF2 PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

90Connections

3Hypotheses

3Analyses

46Outgoing

44Incoming

0Experiments

3Debates

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💡 Concept Info

Name	NRF2 PATHWAY
Key Genes/Proteins	AKT, AMPK, APP, CREB, CYP46A1, ERK
Related Diseases	APOPTOSIS, AUTOPHAGY, CELL DEATH, CHOLESTEROL

Pathway Diagram

graph TD
    NRF2_PATHWAY["NRF2 PATHWAY"]
    NRF2_PATHWAY -->|"treats"| ROS["ROS"]
    NRF2_PATHWAY -->|"interacts"| CHOLESTEROL["CHOLESTEROL"]
    SQSTM1["SQSTM1"] -->|"interacts"| NRF2_PATHWAY
    Memantine["Memantine"] -->|"activates"| NRF2_PATHWAY
    Epigallocatechin_Gallate["Epigallocatechin Gallate"] -->|"targets"| NRF2_PATHWAY
    NRF2["NRF2"] -->|"treats"| NRF2_PATHWAY
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"] -->|"activates"| NRF2_PATHWAY
    DIMETHYL_FUMARATE["DIMETHYL FUMARATE"] -->|"activates"| NRF2_PATHWAY

Outgoing (46)

Target	Relation	Type	Str
neuroprotection	activates	phenotype	0.70
neuroprotection	mediates	phenotype	0.70
AUTOPHAGY	causes	phenotype	0.65
APOPTOSIS	inhibits	phenotype	0.65
INFLAMMATION	inhibits	phenotype	0.65
ROS	treats	phenotype	0.65
CHOLESTEROL	interacts_with	phenotype	0.65
FERROPTOSIS	protects_against	phenotype	0.65
SLC1A2	associated_with	gene	0.50
GLUTAMATE	associated_with	phenotype	0.50
CYP46A1	associated_with	gene	0.50
CELL DEATH	associated_with	phenotype	0.50
MAPK	associated_with	gene	0.50
KEAP1	associated_with	gene	0.45
PARKINSON	associated_with	disease	0.45
AUTOPHAGY	associated_with	phenotype	0.45
ISCHEMIA	associated_with	disease	0.45
ASTROCYTE	associated_with	cell_type	0.45
APP	associated_with	gene	0.45
HDAC3	associated_with	gene	0.45
AKT	associated_with	gene	0.45
PRAMIPEXOLE	associated_with	drug	0.45
CHOLESTEROL	associated_with	phenotype	0.45
STROKE	associated_with	disease	0.45
FERROPTOSIS	associated_with	phenotype	0.45
PI3K	associated_with	gene	0.45
SIRT1	associated_with	gene	0.45
STAT3	associated_with	gene	0.45
TGFB1	associated_with	gene	0.45
MITOPHAGY	associated_with	phenotype	0.45
AMPK	associated_with	gene	0.45
SUPEROXIDE	associated_with	phenotype	0.45
CORTEX	associated_with	brain_region	0.45
NEURONS	associated_with	cell_type	0.45
ROS	associated_with	phenotype	0.45
MEMANTINE	associated_with	drug	0.45
MELATONIN	associated_with	drug	0.45
NRF2	associated_with	gene	0.45
APOPTOSIS	associated_with	phenotype	0.45
ERK	associated_with	gene	0.45
CREB	associated_with	gene	0.45
ASTROCYTES	associated_with	cell_type	0.45
SOD1	associated_with	gene	0.45
MICROGLIA	associated_with	cell_type	0.45
HO-1	associated_with	gene	0.45
NLRP3	associated_with	gene	0.45

Incoming (44)

Source	Relation	Type	Str
SQSTM1	interacts_with	gene	0.91
35766110	target	paper	0.90
Oxidative Stress	inhibits	process	0.90
Epigallocatechin Gallate	targets	compound	0.80
Memantine	activates	drug	0.80
MT1 receptor	regulates	protein	0.70
melatonin	activates	drug	0.70
salicylates	activates	drug	0.70
CYP46A1	regulates	gene	0.70
CYP46A1	inhibits	gene	0.70
ASTROCYTES	interacts_with	cell_type	0.65
NRF2	treats	gene	0.65
NRF2	targets	gene	0.65
NRF2	activates	gene	0.65
MITOCHONDRIAL DYSFUNCTION	activates	phenotype	0.65
DIMETHYL FUMARATE	activates	drug	0.65
OXIDATIVE STRESS	inhibits	phenotype	0.65
ASTROCYTES	inhibits	cell_type	0.65
ASTROCYTES	regulates	cell_type	0.65
ASTROCYTE	activates	cell_type	0.65
STROKE	activates	disease	0.65
STROKE	inhibits	disease	0.65
FERROPTOSIS	regulates	phenotype	0.65
OXIDATIVE STRESS	regulates	phenotype	0.65
ASTROCYTE	targets	cell_type	0.65
MELATONIN	activates	drug	0.65
APOPTOSIS	regulates	phenotype	0.65
ROS	activates	phenotype	0.65
MULTIPLE SCLEROSIS	activates	disease	0.65
SIRT1	regulates	gene	0.65
ISCHEMIA	activates	disease	0.65
ISCHEMIA	regulates	disease	0.65
NRF2	implicated_in	gene	0.55
OLIGODENDROCYTES	associated_with	cell_type	0.45
NEUROINFLAMMATION	associated_with	phenotype	0.45
PARKINSON'S DISEASE	associated_with	disease	0.45
OXIDATIVE STRESS	associated_with	phenotype	0.45
DIMETHYL FUMARATE	associated_with	drug	0.45
MITOCHONDRIAL DYSFUNCTION	associated_with	phenotype	0.45
NEURODEGENERATION	associated_with	disease	0.45
OLIGODENDROCYTE	associated_with	cell_type	0.45
ENDOTHELIAL CELLS	associated_with	cell_type	0.45
INFLAMMATION	associated_with	phenotype	0.45
MULTIPLE SCLEROSIS	associated_with	disease	0.45

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Nrf2 Pathway Activation Compensates for Progranulin Haploins	0.630	neurodegeneration	Test
NRF2 pathway activation to reduce mutant huntingtin aggregat	0.540	neurodegeneration	Test
NRF2 Pathway Activation for Neuroprotection	0.000	-	4R-tau strain-specific spreading pattern