biological_process

EPIGENETIC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EPIGENETIC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2326Connections

12Hypotheses

19Analyses

18Outgoing

50Incoming

No summary available yet. View on Wiki →

🧬 Biological Process Info

Name	EPIGENETIC
Summary	Page for CRISPRi Epigenetic Silencing of SNCA for Parkinson's Disease
Key Genes/Proteins	PRMT1, SRPK1, TET2, HK2, GJA1, LAMP1
Linked Hypotheses	19 hypotheses

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    EPIGENETIC["EPIGENETIC"] -->|"causes"| MICROGLIA["MICROGLIA"]
    style MICROGLIA fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    EPIGENETIC["EPIGENETIC"] -->|"activates"| PHAGOCYTOSIS["PHAGOCYTOSIS"]
    style PHAGOCYTOSIS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    EPIGENETIC["EPIGENETIC"] -->|"promotes"| RAGE["RAGE"]
    style RAGE fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    EPIGENETIC["EPIGENETIC"] -->|"exacerbates"| ISCHEMIC["ISCHEMIC"]
    style ISCHEMIC fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    EPIGENETIC["EPIGENETIC"] -->|"exacerbates"| STROKE["STROKE"]
    style STROKE fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    EPIGENETIC["EPIGENETIC"] -->|"activates"| UBIQUITIN["UBIQUITIN"]
    style UBIQUITIN fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    EPIGENETIC["EPIGENETIC"] -->|"regulates"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
    style NEUROINFLAMMATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    DNA_METHYLATION["DNA METHYLATION"] -->|"causes"| EPIGENETIC["EPIGENETIC"]
    style DNA_METHYLATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    BDNF["BDNF"] -->|"promotes"| EPIGENETIC["EPIGENETIC"]
    style BDNF fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    AUTOPHAGY["AUTOPHAGY"] -->|"targets"| EPIGENETIC["EPIGENETIC"]
    style AUTOPHAGY fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    APOPTOSIS["APOPTOSIS"] -->|"promotes"| EPIGENETIC["EPIGENETIC"]
    style APOPTOSIS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    DNA_DAMAGE["DNA DAMAGE"] -->|"promotes"| EPIGENETIC["EPIGENETIC"]
    style DNA_DAMAGE fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    style EPIGENETIC fill:#5d4400,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (97)

Target	Relation	Type	Str
T CELL	co_discussed	entity	0.50
STING	co_discussed	entity	0.50
HISTONE	co_discussed	entity	0.50
MACROPHAGE	co_discussed	entity	0.50
SIRT6	co_discussed	entity	0.50
SENESCENCE	co_discussed	entity	0.50
MITOCHONDRIA	co_discussed	entity	0.50
MITOCHONDRIAL DYSFUNCTION	co_discussed	entity	0.50
PROTEOSTASIS	co_discussed	entity	0.50
NEURON	co_discussed	entity	0.50
NEURONS	co_discussed	entity	0.50
OXIDATIVE STRESS	co_discussed	entity	0.50
SYNAPSE	co_discussed	entity	0.50
STAT3	co_discussed	entity	0.50
TFEB	co_discussed	entity	0.50
MACROPHAGES	co_discussed	entity	0.50
FERROPTOSIS	co_discussed	entity	0.50
GLIOBLASTOMA	co_discussed	entity	0.50

Incoming (2229)

Source	Relation	Type	Str
PRMT1	modifies	gene	0.55
PRMT1	activates	gene	0.55
SRPK1	modifies	gene	0.55
TET2	modifies	gene	0.55
TET2	neurotoxic	gene	0.55
HK2	regulates	gene	0.55
GJA1	activates	gene	0.55
LAMP1	activates	gene	0.55
OCLN	activates	gene	0.55
TUBB3	activates	gene	0.55
FOXO1	involved_in	gene	0.55
FOXO1	inhibits	gene	0.55
STX17	modifies	gene	0.55
STX17	activates	gene	0.55
ULK1	modifies	gene	0.55
ULK1	activates	gene	0.55
CRH	modifies	gene	0.55
CRH	involved_in	gene	0.55
BCL2L1	activates	gene	0.55
HNRNPA2B1	inhibits	gene	0.55
SIRT6	regulates	gene	0.55
SIRT6	involved_in	gene	0.55
SIRT6	inhibits	gene	0.55
HK2	activates	gene	0.55
HK2	inhibits	gene	0.55
HK2	involved_in	gene	0.55
AQP1	involved_in	gene	0.55
SIRT3	activates	gene	0.55
TFAM	activates	gene	0.55
TLR4	activates	gene	0.55
BDNF	involved_in	gene	0.55
OCLN	modifies	gene	0.55
SIRT3	involved_in	gene	0.55
PRMT1	inhibits	gene	0.55
MAPT	modifies	gene	0.55
FOXO3	activates	gene	0.55
FOXO3	modifies	gene	0.55
NPM1	involved_in	gene	0.55
ST3GAL2	modifies	gene	0.55
ST6GAL1	modifies	gene	0.55
CACNA1G	modifies	gene	0.55
CACNA1G	regulates	gene	0.55
MTNR1A	modifies	gene	0.55
MTNR1B	modifies	gene	0.55
TLR4	inhibits	gene	0.55
PVALB	regulates	gene	0.55
FKBP5	involved_in	gene	0.55
NR3C1	involved_in	gene	0.55
NR3C1	modifies	gene	0.55
FKBP5	modifies	gene	0.55

Targeting Hypotheses (12)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Nutrient-Sensing Epigenetic Circuit Reactivation	0.670	neurodegeneration	Epigenetic reprogramming in aging neuron
Epigenetic Memory Reprogramming via CRISPRa-Mediated Chromat	0.517	neurodegeneration	CRISPR-based therapeutic approaches for
Epigenetic Memory Erasure via TET2 Activation	0.515	neurodegeneration	Astrocyte reactivity subtypes in neurode
Epigenetic Reprogramming of Microglial Memory	0.508	Alzheimer's disease	Neuroinflammation and microglial priming
SIRT1-Mediated Epigenetic Restoration of MFSD2A Expression R	0.498	neuropharmacology	What determines blood-brain barrier pene

EV-Mediated Epigenetic Reprogramming	0.490	neurodegeneration	Extracellular vesicle biomarkers for ear
EV-Mediated Epigenetic Reprogramming	0.486	neurodegeneration	Extracellular vesicle biomarkers for ear
Astrocyte-Mediated Neuronal Epigenetic Rescue	0.479	neurodegeneration	Epigenetic reprogramming in aging neuron
Epigenetic Memory Reprogramming for Alzheimer's Disease	0.467	neurodegeneration	CRISPR-based therapeutic approaches for
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration	0.448	neurodegeneration	Epigenetic reprogramming in aging neuron
Programmable Neuronal Circuit Repair via Epigenetic CRISPR	0.423	neurodegeneration	CRISPR-based therapeutic approaches for
FOXO3-Longevity Pathway Epigenetic Reprogramming	0.386	neurodegeneration	Epigenetic clocks and biological aging i

Mentioning Analyses (19)

Scientific analyses that reference this entity

Are age-related static epigenetic patterns pathogenic or protective compensatory

epigenetics | 2026-04-15 | 0 hypotheses

What molecular mechanisms drive neuron-to-glioma synapse formation in high-neura

neuro-oncology | 2026-04-13 | 0 hypotheses

How does HDAC1/2 deletion specifically enhance microglial amyloid phagocytosis c

neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.444

How can CRISPR systems achieve persistent therapeutic effects while avoiding chr

gene therapy | 2026-04-11 | 0 hypotheses

Do migratory animals encode specific spatial locations epigenetically or rely on

behavioral neuroscience | 2026-04-11 | 0 hypotheses

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Clonal Hematopoiesis in Nonmalignant Disease: Functional Consequences of Mutated [PMID:40929507]	Koh Y, Tengesdal IW, Jaiswal S	Annu Rev Pathol	2026	1
Single-cell multiregion epigenomic rewiring in Alzheimer's disease progression a [PMID:40752494]	Liu Z, Zhang S, James BT, Galani K, Mang	Cell	2025	1
Utilization of fluid-based biomarkers as endpoints in disease-modifying clinical [PMID:38678292]	Oosthoek M, Vermunt L, de Wilde A, Bonge	Alzheimer's research & therapy	2024	1
TET2 guards against unchecked BATF3-induced CAR T cell expansion. [PMID:36755094]	Jain N, Zhao Z, Feucht J, Koche R, Iyer	Nature	2023	1
Clonal Hematopoiesis of Indeterminate Potential: Current Understanding and Futur [PMID:36928826]	Singh I, Singh A	Curr Oncol Rep	2023	1
Detailed stratified GWAS analysis for severe COVID-19 in four European populatio [PMID:35848942]	Degenhardt F, Ellinghaus D, Juzenas S, L	Human molecular genetics	2022	1
The function and regulation of TET2 in innate immunity and inflammation. [PMID:33085059]	Cong B, Zhang Q, Cao X	Protein Cell	2021	1
Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Hom [PMID:29548672]	Datta M, Staszewski O, Raschi E, Frosch	Immunity	2018	1
Depression as a risk factor for Alzheimer's disease: Genes, steroids, cytokines [PMID:26746105]	Herbert J, Lucassen PJ	Frontiers in neuroendocrinolog	2016	1
Global epigenomic reconfiguration during mammalian brain development. [PMID:23828890]	Lister R, Mukamel EA, Nery JR, Urich M,	Science	2013	1
Homoplantaginin ameliorates osteoarthritis by activating Sirt3/PINK1/Parkin sign [PMID:41720004]	Zhang H, Xiao J, Yi Y, Chen B, Lv W et a	Phytomedicine	2026	0
Kakkalide promotes spinal cord injury repair by regulating microglial M2 polariz [PMID:41720005]	You T, Dai B, Ding X, He Z, Peng J et al	Phytomedicine	2026	0
α7-nAChR activation mitigates pyridaben-induced hepatotoxicity in grass carp (Ct [PMID:41966317]	Wu C, Jiang J, Qiu H, Xie J, Li S	Fish Shellfish Immunol	2026	0
Targeting synaptic plasticity and acetylcholine dysregulation in the medial pref [PMID:41014339]	Shi J, Chen M, Zhang Y, Fan X, Wang L et	Psychopharmacology (Berl)	2026	0
NAD+ subcellular partitioning mediated by miR-183 and miR-96 regulates muscle st [PMID:41915008]	Ma M, Ma R, Li Z, Shen S, Kong W, Qiu T,	Journal of molecular cell biol	2026	0
Rhodiola sacra Protects Against Hippocampal Neuronal Apoptosis in Chronic Cerebr [PMID:41879438]	Zhou L, Jia J, Li J, Yao Z, Fu Z, Wang S	Current neuropharmacology	2026	0
Mechanistic Modulation of Autophagy by Bioactive Natural Products: Implications [PMID:41830033]	Jalouli M, Harrath AH, Al-Zharani M, Rah	Nutrients	2026	0
Mechanistic advances in exercise‑mediated regulation of autophagy dysfunction in [PMID:41645754]	Li W, Wang WH, Song Y, Li XJ, Li Y et al	Int J Mol Med	2026	0
Unravelling the therapeutic potential of chrysin against ischemic stroke and pos [PMID:41687709]	Achar PG, Krishna KL, C P K, Patil M, Pr	Neuroscience	2026	0
Loss of REST associated with Alzheimer's disease pathology is ameliorated by NAD [PMID:41709697]	Lagartos-Donate MJ, Escobar-Doncel B, Zh	Brain	2026	0

EPIGENETIC

Understanding Entity Pages

Wiki Pages (21)

CRISPRi Epigenetic Silencing of SNCA for Parkinson's Disease

Progressive Supranuclear Palsy (PSP)

Novel Therapy Index

CBS/PSP Supplements Guide

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Alzheimer's Disease Mechanism Index

Pathway Diagram

Outgoing (97)

Incoming (2229)

Targeting Hypotheses (12)

Mentioning Analyses (19)

Are age-related static epigenetic patterns pathogenic or protective compensatory

What molecular mechanisms drive neuron-to-glioma synapse formation in high-neura

How does HDAC1/2 deletion specifically enhance microglial amyloid phagocytosis c

How can CRISPR systems achieve persistent therapeutic effects while avoiding chr

Do migratory animals encode specific spatial locations epigenetically or rely on

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

Investigate mechanisms of epigenetic reprogramming in aging neurons

Investigate mechanisms of epigenetic reprogramming in aging neurons

Do different priming stimuli require distinct therapeutic approaches or share co

How can CNS-selective HDAC/DNMT inhibitors be developed to avoid systemic toxici

Investigate mechanisms of epigenetic reprogramming in aging neurons

Epigenetic reprogramming in aging neurons

epigenetic reprogramming aging neurons

CRISPR-based therapeutic approaches for neurodegenerative diseases

Epigenetic reprogramming in aging neurons

CRISPR-based therapeutic approaches for neurodegenerative diseases

Epigenetic clocks and biological aging in neurodegeneration

Epigenetic clocks and biological aging in neurodegeneration

Related Papers (20)

EPIGENETIC

Understanding Entity Pages

Wiki Pages (21)

CRISPRi Epigenetic Silencing of SNCA for Parkinson's Disease

Progressive Supranuclear Palsy (PSP)

Novel Therapy Index

CBS/PSP Supplements Guide

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Alzheimer's Disease Mechanism Index

Neuroresilience Mechanisms and Evidence

Therapeutics

NPM1 Gene

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

Neurons — Cell Type Hierarchy

CBS/PSP Treatment Rankings

NRF2 Oxidative Stress Pathway

Frontotemporal Dementia (FTD)

coq10-neurodegeneration

NTF4 Protein

TREM2 Mechanism Hub

Astrocyte Reactivity Mechanism

HNRNPA2B1 Protein

Growth Factor Therapies

Mitochondrial Dysfunction in Parkinson's Disease

Pathway Diagram

Outgoing (97)

Incoming (2229)

Targeting Hypotheses (12)

Mentioning Analyses (19)

Are age-related static epigenetic patterns pathogenic or protective compensatory

What molecular mechanisms drive neuron-to-glioma synapse formation in high-neura

How does HDAC1/2 deletion specifically enhance microglial amyloid phagocytosis c

How can CRISPR systems achieve persistent therapeutic effects while avoiding chr

Do migratory animals encode specific spatial locations epigenetically or rely on

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

Investigate mechanisms of epigenetic reprogramming in aging neurons

Investigate mechanisms of epigenetic reprogramming in aging neurons

Do different priming stimuli require distinct therapeutic approaches or share co

How can CNS-selective HDAC/DNMT inhibitors be developed to avoid systemic toxici

Investigate mechanisms of epigenetic reprogramming in aging neurons

Epigenetic reprogramming in aging neurons

epigenetic reprogramming aging neurons

CRISPR-based therapeutic approaches for neurodegenerative diseases

Epigenetic reprogramming in aging neurons

CRISPR-based therapeutic approaches for neurodegenerative diseases

Epigenetic clocks and biological aging in neurodegeneration

Epigenetic clocks and biological aging in neurodegeneration

Related Papers (20)