concept

T CELL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about T CELL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2339Connections

2Hypotheses

17Analyses

50Outgoing

50Incoming

Summary

T CELL is a concept in neurodegeneration research. Key relationships include: co discussed, activates, associated with. Associated with ALZHEIMER'S DISEASE, CANCER, ENCEPHALITIS. Connected to 200 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	T CELL
Related Diseases	NEURODEGENERATION, ALZHEIMER'S DISEASE, TUMOR
Linked Hypotheses	2 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Pathway Diagram

graph TD
    T_CELL["T CELL"]
    COMPLEMENT["COMPLEMENT"] -->|"expressed in"| T_CELL
    HSPG2["HSPG2"] -->|"expressed in"| T_CELL
    CANCER["CANCER"] -->|"expressed in"| T_CELL
    TCR["TCR"] -->|"expressed in"| T_CELL
    CD40["CD40"] -->|"expressed in"| T_CELL
    AQP4["AQP4"] -->|"expressed in"| T_CELL
    HSPA1A["HSPA1A"] -->|"expressed in"| T_CELL
    APOPTOSIS["APOPTOSIS"] -->|"expressed in"| T_CELL
    NEURODEGENERATION["NEURODEGENERATION"] -->|"expressed in"| T_CELL
    HSP70["HSP70"] -->|"expressed in"| T_CELL

Outgoing (132)

Target	Relation	Type	Str
TUMOR	treats	disease	0.65
TUMOR	causes	disease	0.65
TUMOR	interacts_with	disease	0.65
T CELLS	accumulates_in	cell_type	0.65
T CELLS	reduces	cell_type	0.65
TUMOR	increases	disease	0.65
T CELLS	mediates	cell_type	0.65
T CELLS	transports	cell_type	0.65
T CELLS	increases	cell_type	0.65
TUMOR	protects_against	disease	0.65
TAU	activates	gene	0.65
TAU	phosphorylates	gene	0.65
TAU	interacts_with	gene	0.65
TAU	expressed_in	gene	0.65
UBIQUITIN	inhibits	gene	0.65
TNF	mediates	gene	0.65
T CELLS	expressed_in	cell_type	0.60
T CELLS	inhibits	cell_type	0.60
TUMOR	transports	disease	0.60
T CELLS	contributes_to	cell_type	0.60
TUMOR	contributes_to	disease	0.60
T CELLS	regulates	cell_type	0.60
T CELLS	interacts_with	cell_type	0.60
T CELLS	activates	cell_type	0.60
T CELLS	promotes	cell_type	0.60
TNF	causes	gene	0.60
TUMOR	activates	disease	0.60
T CELLS	protects_against	cell_type	0.60
T CELLS	treats	cell_type	0.60
TUMOR	inhibits	disease	0.60
T CELLS	associated_with	cell_type	0.60
T CELLS	stabilizes	cell_type	0.60
T CELLS	targets	cell_type	0.60
T CELLS	impairs	cell_type	0.60
TUMOR	regulates	disease	0.60
TNF	activates	gene	0.60
T CELLS	causes	cell_type	0.60
TUMOR	targets	disease	0.60
TBI	protects_against	disease	0.60
TUMOR	associated_with	disease	0.60
TUMOR	promotes	disease	0.60
T CELLS	co_discussed	entity	0.50
TBI	co_discussed	entity	0.50
TNF	co_discussed	entity	0.50
TREM2	co_discussed	entity	0.50
ULK1	co_discussed	entity	0.50
NEUROINFLAMMATION	activates	process	0.50
METFORMIN	inhibits	drug	0.50
CANCER	regulates	disease	0.50
INFLAMMATION	activates	process	0.50

Incoming (2207)

Source	Relation	Type	Str
PARKINSON'S DISEASE	associated_with	disease	0.90
TET2	regulates	entity	0.90
NEURODEGENERATION	associated_with	disease	0.82
SLC16A1	expressed_in	entity	0.80
MICROGLIA	associated_with	cell_type	0.74
ALZHEIMER'S DISEASE	associated_with	disease	0.74
TNF	activates	gene	0.66
CSF1R	inhibits	gene	0.65
NOTCH	causes	gene	0.65
CANCER	treats	disease	0.65
CANCER	targets	disease	0.65
NK CELL	activates	cell_type	0.65
MICROGLIA	accumulates_in	cell_type	0.65
SPINAL CORD	activates	brain_region	0.65
ENDOTHELIAL	contributes_to	cell_type	0.65
STING	inhibits	gene	0.65
NEUTROPHIL	increases	cell_type	0.65
ASTROCYTE	interacts_with	cell_type	0.65
ASTROCYTES	interacts_with	cell_type	0.65
NEURODEGENERATION	treats	disease	0.65
AKT	activates	gene	0.65
MTOR	activates	gene	0.65
PI3K	causes	gene	0.65
NEURON	activates	cell_type	0.65
ALZHEIMER	causes	disease	0.65
ALZHEIMER'S	causes	disease	0.65
ALZHEIMER'S DISEASE	causes	disease	0.65
IL-6	transports	gene	0.65
MICROGLIA	transports	cell_type	0.65
CANCER	contributes_to	disease	0.65
NEURON	promotes	cell_type	0.65
NEURODEGENERATION	accumulates_in	disease	0.65
STING	targets	gene	0.65
MTOR	regulates	gene	0.65
MTOR	inhibits	gene	0.65
MYC	inhibits	gene	0.65
MTOR	reduces	gene	0.65
FOXP3	regulates	gene	0.65
GLIOMA	expressed_in	disease	0.65
P53	activates	gene	0.65
ISCHEMIA	inhibits	disease	0.65
OCLN	inhibits	gene	0.65
P62	degrades	gene	0.65
AKT	regulates	gene	0.65
METFORMIN	regulates	drug	0.65
STING	phosphorylates	gene	0.65
PARKIN	targets	gene	0.65
PARKINSON	targets	disease	0.65
PARKINSON'S DISEASE	targets	disease	0.65
RAPAMYCIN	treats	drug	0.65

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Senescent Cell ASM-Complement Cascade Intervention	0.552	neurodegeneration	Lipid raft composition changes in synapt
Senescent Cell Mitochondrial DNA Release	0.545	neurodegeneration	Senolytic therapy for age-related neurod

Mentioning Analyses (17)

Scientific analyses that reference this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745]	Yu CH, Davidson S, Harapas CR, Hilton JB	Cell	2020	2
Stimuli-responsive nanoplatforms for precision activation of the STING pathway i [PMID:41668757]	["Bi D", "Yang X", "Wang Y", "Yong J", "	Frontiers in immunology	2026	0
Decoding senescent drivers in Alzheimer's disease: From bench to bedside. [PMID:41344577]	["Zhou R", "Lin X", "Liao Z", "Lin J", "	Ageing research reviews	2026	0
Role of NEIL1 in genome maintenance. [PMID:40010204]	["McCullough A", "Minko I", "Luzadder M"	DNA repair	2025	0
Bionanoconjugates in Neurodegeneration: Peptide-Nanoparticle Alliances for Next- [PMID:41199078]	["Ranjitha V", "Kumar A", "Kaalappa P"]	Pharmaceutical research	2025	0
Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven imm [PMID:40203808]	["Lai P", "Liu L", "Bancaro N", "Troiani	Immunity	2025	0
Apheresis for senescence: Targeting the senescence-associated secretory phenotyp [PMID:40651559]	["Akgun Y"]	Ageing research reviews	2025	0
Methodological influences on circulating cell-free-mitochondrial and nuclear DNA [PMID:40080226]	["Daubermann C", "Herhaus B", "Neuberger	Molecular biology reports	2025	0
Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflamma [PMID:40902587]	["Song Z", "Xie X", "Chen Y", "Zhang B",	Immunity	2025	0
Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746]	["Sanadgol N", "Abedi M", "Hashemzaei M"	Journal of nanobiotechnology	2025	0
Acid sphingomyelinase activity suggests a new antipsychotic pharmaco-treatment s [PMID:39825014]	Chestnykh D, Mühle C, Schumacher F, Kali	Mol Psychiatry	2025	0
Large-scale Plasma Proteomic Profiling Unveils Novel Diagnostic Biomarkers and P [PMID:40166037]	Cruchaga C, Heo G, Thomas A, Wang E, Oh	Res Sq	2025	0
Reduction of sphingomyelinase activity associated with progranulin deficiency an [PMID:40633679]	Boyle NR, Fox SN, Tadepalli AS, Seyfried	Neurobiol Dis	2025	0
Antileukemic potential of methylated indolequinone MAC681 through immunogenic ne [PMID:38704604]	["Orlikova-Boyer B", "Lorant A", "Gajula	Biomarker research	2024	0
Enhancing Radiofrequency Ablation for Hepatocellular Carcinoma: Nano-Epidrug Eff [PMID:39548919]	["Li X", "Liu Y", "Ke J", "Wang Z", "Han	Advanced materials (Deerfield	2024	0
The cGAS-STING pathway drives neuroinflammation and neurodegeneration via cellul [PMID:39490400]	Zhang Y, Zou M, Wu H, Zhu J, Jin T	Neurobiology of disease	2024	0
mtDNA release promotes cGAS-STING activation and accelerated aging of postmitoti [PMID:39039044]	["Li Y", "Cui J", "Liu L", "Hambright W"	Cell death & disease	2024	0
Senescent glia link mitochondrial dysfunction and lipid accumulation. [PMID:38839958]	["Byrns C", "Perlegos A", "Miller K", "J	Nature	2024	0
Acid sphingomyelinase as a pathological and therapeutic target in neurological d [PMID:38337058]	Choi BJ, Park MH, Jin HK, Bae JS	Exp Mol Med	2024	0
EDIL3/Del-1 prevents aortic dissection through enhancing internalization and deg [PMID:38873925]	Yin Z, Zhang J, Zhao M, Liu J, Xu Y et a	Autophagy	2024	0

T CELL

Understanding Entity Pages

Summary

Wiki Pages (20)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Corticobasal Syndrome (CBS)

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Atypical Parkinsonism

neuroinflammation

Pathway Diagram

Outgoing (132)

Incoming (2207)

Targeting Hypotheses (2)

Mentioning Analyses (17)

Do CXCL10-recruited CD8+ T cells provide neuroprotection or cause damage in agin

Which neural cell types exhibit the most pronounced gene expression alterations

Can metabolic interventions truly reverse established cellular senescence or onl

How do host cell factors influence the conformation and propagation properties o

How do protein-protein interactions determine subcellular localization and funct

What molecular mechanisms drive microglial senescence and the transition to dyst

How can senescent microglia be molecularly distinguished from beneficial activat

Senescent cell clearance as neurodegeneration therapy

Cell type vulnerability in Alzheimer's Disease (SEA-AD data)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Senescent cell clearance as neurodegeneration therapy

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data)

Related Papers (20)

T CELL

Understanding Entity Pages

Summary

Wiki Pages (20)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Corticobasal Syndrome (CBS)

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Atypical Parkinsonism

neuroinflammation

Microglial Cells — Cell Type Hierarchy

GSK-3β in Neurodegeneration

Autophagy Mechanisms

Oligodendrocytes

Vitamin D Signaling Pathway in Neurodegeneration

rankings

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

Spinal Cord Dorsal Horn Neurons

nlrc5-protein

dimethyl-fumarate-nrf2-ad-nct06850597

LRRK2 Kinase Activation and Endolysosomal Dysfunction in Parkinson's Disease

LRRK2 Pathway in Parkinson's Disease

CREB Signaling in Neurodegeneration

Amyloid Cascade Pathway

vitamin-d-therapy-neurodegeneration

Pathway Diagram

Outgoing (132)

Incoming (2207)

Targeting Hypotheses (2)

Mentioning Analyses (17)

Do CXCL10-recruited CD8+ T cells provide neuroprotection or cause damage in agin

Which neural cell types exhibit the most pronounced gene expression alterations

Can metabolic interventions truly reverse established cellular senescence or onl

How do host cell factors influence the conformation and propagation properties o

How do protein-protein interactions determine subcellular localization and funct

What molecular mechanisms drive microglial senescence and the transition to dyst

How can senescent microglia be molecularly distinguished from beneficial activat

Senescent cell clearance as neurodegeneration therapy

Cell type vulnerability in Alzheimer's Disease (SEA-AD data)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Senescent cell clearance as neurodegeneration therapy

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data)

Related Papers (20)