Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HISTONE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | HISTONE |
| Summary | # [Histone Deacetylase](/entities/hdac-enzymes) ([HDAC](/entities/hdac-enzymes)) Enzymes ## Introduction [Histone Deacetylase](/entities/hdac-enzymes) (Hdac) Enzymes is an important component in the |
Knowledge base pages for this entity
graph TD
HISTONE["HISTONE"]
HISTONE -->|"involved_in"| Epigenomic_Reconfiguration["Epigenomic Reconfiguration"]
HISTONE ---|"co-discussed"| MACROPHAGE["MACROPHAGE"]
HISTONE ---|"co-discussed"| MACROPHAGES["MACROPHAGES"]
HISTONE ---|"co-discussed"| LAMP1["LAMP1"]
HISTONE ---|"co-discussed"| OCLN["OCLN"]
HISTONE ---|"co-discussed"| P62["P62"]
PROTAMINE["PROTAMINE"] -->|"interacts"| HISTONE
DNA_METHYLATION["DNA METHYLATION"] ---|"co-discussed"| HISTONE
EPIGENETIC["EPIGENETIC"] ---|"co-discussed"| HISTONE
AUTOPHAGY["AUTOPHAGY"] ---|"co-discussed"| HISTONE
BECN1["BECN1"] ---|"co-discussed"| HISTONE
CREB["CREB"] ---|"co-discussed"| HISTONE| Target | Relation | Type | Str |
|---|---|---|---|
| Epigenomic Reconfiguration | involved_in | process | 0.90 |
| MACROPHAGE | co_discussed | entity | 0.50 |
| MACROPHAGES | co_discussed | entity | 0.50 |
| LAMP1 | co_discussed | entity | 0.50 |
| OCLN | co_discussed | entity | 0.50 |
| P62 | co_discussed | entity | 0.50 |
| TFEB | co_discussed | entity | 0.50 |
| LC3 | co_discussed | entity | 0.50 |
| MTOR | co_discussed | entity | 0.50 |
| OPTN | co_discussed | entity | 0.50 |
| ISCHEMIA | co_discussed | entity | 0.50 |
| PARKINSON | co_discussed | entity | 0.50 |
| SIRT6 | co_discussed | entity | 0.50 |
| STING | co_discussed | entity | 0.50 |
| TLR4 | co_discussed | entity | 0.50 |
| MITOCHONDRIA | co_discussed | entity | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PROTAMINE | interacts_with | entity | 0.90 |
| DNA METHYLATION | co_discussed | entity | 0.50 |
| EPIGENETIC | co_discussed | entity | 0.50 |
| AUTOPHAGY | co_discussed | entity | 0.50 |
| BECN1 | co_discussed | entity | 0.50 |
| CREB | co_discussed | entity | 0.50 |
| GABA | co_discussed | entity | 0.50 |
| ATG7 | co_discussed | entity | 0.50 |
| ALZHEIMER | co_discussed | entity | 0.50 |
| CYTOKINE | co_discussed | entity | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.444
neurodegeneration | 2026-04-10 | 0 hypotheses
neurodegeneration | 2026-04-10 | 0 hypotheses
neurodegeneration | 2026-04-04 | 9 hypotheses Top: 0.670
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||