TUBB3

Understanding Entity Pages

This page aggregates everything SciDEX knows about TUBB3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

TUBB3 is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, activates. Associated with ALS, Als, Alzheimer. Connected to 179 entities in the SciDEX knowledge graph.

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flowchart TD
    TUBB3["TUBB3<br/>Neuronal Tubulin<br/>Beta-3"]
    
    %% Microtubule and Cytoskeleton
    Microtubules["Microtubule<br/>Assembly"]
    Cytoskeleton["Neuronal<br/>Cytoskeleton"]
    
    %% Associated Proteins
    HDAC6["HDAC6<br/>Tubulin Deacetylase"]
    VIM["VIM<br/>Vimentin"]
    SRC["SRC<br/>Kinase"]
    
    %% Autophagy Pathway
    BECN1["BECN1<br/>Beclin-1"]
    MAP1LC3B["MAP1LC3B<br/>LC3B"]
    Autophagy["Autophagy<br/>Process"]
    
    %% Neurodegenerative Diseases
    Alzheimer["Alzheimer's<br/>Disease"]
    Parkinson["Parkinson's<br/>Disease"]
    ALS["ALS<br/>Motor Neuron Disease"]
    Huntington["Huntington's<br/>Disease"]
    MS["Multiple<br/>Sclerosis"]
    
    %% Cellular Processes
    Apoptosis["Neuronal<br/>Apoptosis"]
    Neurodegeneration["Neurodegeneration<br/>Process"]
    
    %% Connections
    TUBB3 --|"forms"|--> Microtubules
    Microtubules --|"maintains"|--> Cytoskeleton
    
    HDAC6 --|"deacetylates"|--> TUBB3
    TUBB3 --|"associates_with"|--> VIM
    TUBB3 --|"inhibits"|--> SRC
    
    TUBB3 --|"regulates"|--> BECN1
    TUBB3 --|"associates_with"|--> MAP1LC3B
    BECN1 --|"initiates"|--> Autophagy
    MAP1LC3B --|"mediates"|--> Autophagy
    
    TUBB3 --|"activates"|--> Alzheimer
    TUBB3 --|"regulates"|--> Parkinson
    TUBB3 --|"therapeutic_target"|--> ALS
    TUBB3 --|"associated_with"|--> Huntington
    TUBB3 --|"activates"|--> MS
    
    TUBB3 --|"therapeutic_target"|--> Apoptosis
    TUBB3 --|"activates"|--> Neurodegeneration
    
    Cytoskeleton --|"dysfunction_leads_to"|--> Neurodegeneration
    Autophagy --|"impairment_causes"|--> Neurodegeneration
    
    %% Styling
    style TUBB3 fill:#006494
    style Autophagy fill:#1b5e20
    style BECN1 fill:#1b5e20
    style Alzheimer fill:#ef5350
    style Parkinson fill:#ef5350
    style ALS fill:#ef5350
    style Huntington fill:#ef5350
    style MS fill:#ef5350
    style Neurodegeneration fill:#ef5350
    style Apoptosis fill:#ef5350
    style HDAC6 fill:#4a1a6b
    style SRC fill:#4a1a6b
    style Microtubules fill:#5d4400
    style Cytoskeleton fill:#5d4400