concept

FOXK2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FOXK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

62Connections

0Hypotheses

0Analyses

41Outgoing

21Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	FOXK2
Key Genes/Proteins	SLC7A11, OGT, importin_alpha, IMPORTIN_ALPHA
Related Diseases	Carcinoma, Tumor, Ms, Diabetes, Cancer
Related Pathways	Ferroptosis

Wiki Pages (1)

Knowledge base pages for this entity

SLC7A11 Gene - xCT Cystine/Glutamate Antiporter

gene · 809 words

→

Pathway Diagram

graph TD
    FOXK2["FOXK2"]
    FOXK2 -->|"regulates"| SLC7A11["SLC7A11"]
    FOXK2 -->|"contributes to"| Carcinoma["Carcinoma"]
    FOXK2 -->|"contributes to"| Tumor["Tumor"]
    FOXK2 -->|"activates"| Ms["Ms"]
    FOXK2 -->|"expressed in"| Diabetes["Diabetes"]
    FOXK2 -->|"expressed in"| Cancer["Cancer"]
    FOXK2 -->|"interacts"| importin_alpha["importin_alpha"]
    FOXK2 -->|"interacts"| IMPORTIN_ALPHA["IMPORTIN_ALPHA"]
    OGT["OGT"] -->|"regulates"| FOXK2
    FERROPTOSIS["FERROPTOSIS"] -->|"activates"| FOXK2
    ROS["ROS"] -->|"activates"| FOXK2
    SLC7A11 -->|"activates"| FOXK2
    SHH["SHH"] -->|"expressed in"| FOXK2
    GENES["GENES"] -->|"expressed in"| FOXK2

Outgoing (41)

Target	Relation	Type	Str
SLC7A11	upregulates	gene	0.95
SLC7A11	regulates	gene	0.72
Carcinoma	contributes_to	disease	0.65
Tumor	contributes_to	disease	0.65
Ms	activates	disease	0.65
Diabetes	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Carcinoma	expressed_in	disease	0.65
importin_alpha	interacts_with	protein	0.64
IMPORTIN_ALPHA	interacts_with	protein	0.64
SLC7A11	activates	gene	0.60
Ferroptosis	activates	pathway	0.60
OGT	activates	gene	0.60
FOXO3	associated_with	gene	0.60
FOXP3	associated_with	gene	0.60
FOXG1	associated_with	gene	0.60
FOXD3	associated_with	gene	0.60
SHH	expressed_in	gene	0.60
FOXN3	associated_with	gene	0.60
FOXP1	associated_with	gene	0.60
CANCER	expressed_in	gene	0.60
FOXM1	associated_with	gene	0.60
FOXP4	associated_with	gene	0.60
DIABETES MELLITUS	expressed_in	gene	0.60
FOXO4	associated_with	gene	0.60
FOXO1	associated_with	gene	0.60
FOXP2	associated_with	gene	0.60
Epigenetic	expressed_in	pathway	0.60
Hedgehog	expressed_in	pathway	0.60
FERROPTOSIS	activates	gene	0.60
FOXA2	associated_with	gene	0.60
FOXO6	associated_with	gene	0.60
AND	associated_with	gene	0.60
AND	activates	gene	0.60
ROS	activates	gene	0.60
Ras	activates	protein	0.60
OGT	implicated_in	gene	0.60
SLC7A11	implicated_in	gene	0.60
oxidative stress response	participates_in	pathway	0.60
ferroptosis	participates_in	pathway	0.60
ferroptosis	activates	process	0.60

Incoming (21)

Source	Relation	Type	Str
OGT	O-GlcNAcylates	protein	0.90
OGT	regulates	protein	0.64
OGT	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
FOXA2	associated_with	gene	0.60
FOXO6	associated_with	gene	0.60
ROS	activates	gene	0.60
SLC7A11	activates	gene	0.60
FOXD3	associated_with	gene	0.60
FOXO1	associated_with	gene	0.60
FOXP3	associated_with	gene	0.60
FOXO4	associated_with	gene	0.60
FOXP1	associated_with	gene	0.60
SHH	expressed_in	gene	0.60
FOXO3	associated_with	gene	0.60
GENES	expressed_in	gene	0.60
FOXP2	associated_with	gene	0.60
SLC7A11	associated_with	gene	0.50
CARCINOMA	associated_with	disease	0.50
HEPATOCELLULAR CARCINOMA	associated_with	disease	0.50
ferroptosis	activates	phenotype	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found