gene

FOXO6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FOXO6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

67Connections
0Hypotheses
0Analyses
45Outgoing
22Incoming

Summary

FOXO6 is a gene implicated in neurodegeneration research. Key relationships include: associated with, expressed in, therapeutic target. Associated with Als, Cancer, Carcinoma. Connected to 25 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolFOXO6
Chromosome1p33
Protein TypeTranscription Factor
FunctionSynaptic plasticity: BDNF, ARC, EGR1 immediate early genes
Amino Acids524 aa
Exons3
Ensembl IDENSG00000204060
GeneCardsFOXO6
Human Protein AtlasFOXO6
Forkhead DNA-binding domainWinged-helix structure for DNA recognition
Nuclear localization signalRegulates subcellular distribution
Transactivation domainInteracts with co-activators
Spatial memoryRequired for Morris water maze performance
Contextual fear conditioningRegulates memory consolidation
Synaptic plasticityModulates long-term potentiation (LTP)
Associated DiseasesAls
InteractionsCANCER
KG Connections67 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

FOXO6 Gene

gene · 817 words

FOXO4 — Forkhead Box O4

gene · 3329 words

FOXO1 Gene

gene · 1837 words

Transcription Regulation Pathway

mechanism · 1719 words

CREB-independent Neuronal Survival Pathways

mechanism · 1539 words

FOXO Signaling Pathway in Neurodegeneration

mechanism · 901 words

Pathway Diagram

graph TD
    FOXO6["<b>FOXO6</b>"]
    Diabetes{"Diabetes"}
    FOXO6 -->|"expressed in"| Diabetes
    Cancer{"Cancer"}
    FOXO6 -->|"expressed in"| Cancer
    Carcinoma{"Carcinoma"}
    FOXO6 -->|"expressed in"| Carcinoma
    Longevity{"Longevity"}
    FOXO6 -->|"therapeutic target"| Longevity
    Als{"Als"}
    FOXO6 -->|"associated with"| Als
    Tumor{"Tumor"}
    FOXO6 -->|"therapeutic target"| Tumor
    FOXK2["FOXK2"]
    FOXO6 -->|"associated with"| FOXK2
    FOXO3["FOXO3"]
    FOXO6 -->|"associated with"| FOXO3
    FOXP3["FOXP3"]
    FOXO6 -->|"associated with"| FOXP3
    FOXG1["FOXG1"]
    FOXO6 -->|"associated with"| FOXG1
    FOXD3["FOXD3"]
    FOXO6 -->|"associated with"| FOXD3
    SHH["SHH"]
    FOXO6 -->|"expressed in"| SHH
    FOXA2["FOXA2"]
    FOXA2 -->|"associated with"| FOXO6
    style FOXO6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (45)

TargetRelationTypeStr
Diabetesexpressed_indisease0.65
Cancerexpressed_indisease0.65
Carcinomaexpressed_indisease0.65
Longevitytherapeutic_targetdisease0.65
Alsassociated_withdisease0.65

Incoming (22)

SourceRelationTypeStr
FOXA2associated_withgene0.60
FOXO1associated_withgene0.60
FOXP3associated_withgene0.60
FOXO4associated_withgene0.60
FOXP1associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found