FOXO4

Understanding Entity Pages

This page aggregates everything SciDEX knows about FOXO4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

FOXO4 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, expressed in. Associated with Als, Cancer, Carcinoma. Connected to 44 entities in the SciDEX knowledge graph.

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graph TD
    FOXO4["<b>FOXO4</b>"]
    Ms{"Ms"}
    FOXO4 -->|"activates"| Ms
    Traumatic_Brain_Injury{"Traumatic Brain Injury"}
    FOXO4 -->|"therapeutic target"| Traumatic_Brain_Injury
    Als{"Als"}
    FOXO4 -->|"therapeutic target"| Als
    Diabetes{"Diabetes"}
    FOXO4 -->|"expressed in"| Diabetes
    Cancer{"Cancer"}
    FOXO4 -->|"expressed in"| Cancer
    Carcinoma{"Carcinoma"}
    FOXO4 -->|"expressed in"| Carcinoma
    Longevity{"Longevity"}
    FOXO4 -->|"therapeutic target"| Longevity
    FOXO4 -->|"associated with"| Als
    Tumor{"Tumor"}
    FOXO4 -->|"therapeutic target"| Tumor
    Ubiquitin_Proteasome(["Ubiquitin-Proteasome"])
    FOXO4 -->|"activates"| Ubiquitin_Proteasome
    Akt(["Akt"])
    FOXO4 -->|"activates"| Akt
    Autophagy(["Autophagy"])
    FOXO4 -->|"activates"| Autophagy
    FOXO1["FOXO1"]
    FOXO1 -->|"contributes to"| FOXO4
    AKT["AKT"]
    AKT -->|"activates"| FOXO4
    AMPK["AMPK"]
    AMPK -->|"activates"| FOXO4
    CBL["CBL"]
    CBL -->|"activates"| FOXO4
    FOXA2["FOXA2"]
    FOXA2 -->|"associated with"| FOXO4
    FOXO6["FOXO6"]
    FOXO6 -->|"associated with"| FOXO4
    FOXK2["FOXK2"]
    FOXK2 -->|"associated with"| FOXO4
    FOXO3["FOXO3"]
    FOXO3 -->|"associated with"| FOXO4
    FOXP3["FOXP3"]
    FOXP3 -->|"associated with"| FOXO4
    FOXG1["FOXG1"]
    FOXG1 -->|"associated with"| FOXO4
    FOXD3["FOXD3"]
    FOXD3 -->|"associated with"| FOXO4
    SHH["SHH"]
    SHH -->|"expressed in"| FOXO4
    style FOXO4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0