gene

PRDM1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PRDM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

92Connections

0Hypotheses

0Analyses

46Outgoing

46Incoming

Summary

PRDM1 (PRDI-BF1 and RZ-1 Homolog 1/Blimp-1) - transcriptional repressor involved in plasma cell differentiation, immune regulation, microglial activation, and implicated in neuroinflammatory and neurodegenerative diseases including Alzheimer's and Parkinson's

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🧬 Gene Info

Gene Symbol	PRDM1
Aliases	Blimp-1, PRDI-BF1, B lymphocyte-induced maturation protein 1
Chromosome	6q21
Protein Type	Transcription Factor
Function	encodes a critical transcriptional repressor that controls plasma cell differentiation, immune cell function, and inflammatory responses.
Molecular Weight	~105 kDa
Amino Acids	982 aa
Pathways	Co-inhibitory Gene Module, Nf-Κb
UniProt ID	O75663
NCBI Gene ID	639
Ensembl ID	ENSG00000060656
OMIM	603226
GeneCards	PRDM1
Human Protein Atlas	PRDM1
Gene Name	PRDI-BF1 and RZ-1 Homolog 1 (Blimp-1)
Associated Diseases	ALS, DIABETES
Interactions	CD4, CD8, MAF, CANCER, RNA, PD-1
KG Connections	92 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PRDM1 — AlphaFold O75663 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PRDM1["<b>PRDM1</b>"]
    Cancer{"Cancer"}
    PRDM1 -->|"inhibits"| Cancer
    Als{"Als"}
    PRDM1 -->|"inhibits"| Als
    PRDM1 -->|"activates"| Als
    PRDM1 -->|"activates"| Cancer
    Lymphoma{"Lymphoma"}
    PRDM1 -->|"expressed in"| Lymphoma
    PRDM1 -->|"expressed in"| Als
    Ms{"Ms"}
    PRDM1 -->|"therapeutic target"| Ms
    ALS{"ALS"}
    PRDM1 -->|"inhibits"| ALS
    CD4["CD4"]
    PRDM1 -->|"inhibits"| CD4
    CD8["CD8"]
    PRDM1 -->|"inhibits"| CD8
    Apoptosis(["Apoptosis"])
    PRDM1 -->|"expressed in"| Apoptosis
    Nf__b(["Nf-Kappab"])
    PRDM1 -->|"expressed in"| Nf__b
    MAF["MAF"]
    MAF -->|"inhibits"| PRDM1
    CD8 -->|"inhibits"| PRDM1
    CD4 -->|"inhibits"| PRDM1
    CD4 -->|"activates"| PRDM1
    CD8 -->|"activates"| PRDM1
    CDKN2A["CDKN2A"]
    CDKN2A -->|"regulates"| PRDM1
    TP53["TP53"]
    TP53 -->|"regulates"| PRDM1
    TET2["TET2"]
    TET2 -->|"expressed in"| PRDM1
    MYD88["MYD88"]
    MYD88 -->|"expressed in"| PRDM1
    KMT2D["KMT2D"]
    KMT2D -->|"expressed in"| PRDM1
    NF__B["NF-KappaB"]
    NF__B -->|"expressed in"| PRDM1
    STAT3["STAT3"]
    STAT3 -->|"regulates"| PRDM1
    style PRDM1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (46)

Target	Relation	Type	Str
Co-inhibitory Gene Module	regulates	pathway	0.90
MAF	interacts_with	gene	0.85
Plasma Cell Differentiation	drives	process	0.85
Cancer	inhibits	disease	0.65
Als	inhibits	disease	0.65
Als	activates	disease	0.65
Cancer	activates	disease	0.65
Lymphoma	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Ms	therapeutic_target	disease	0.65
ALS	inhibits	disease	0.65
Cancer	regulates	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Tumor	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Diabetes	associated_with	disease	0.65
Cancer	biomarker_for	disease	0.65
CD4	inhibits	gene	0.60
CD8	inhibits	gene	0.60
TGFBI	regulates	gene	0.60
CD44	regulates	gene	0.60
GJA1	regulates	gene	0.60
CD44	biomarker_for	gene	0.60
TGFBI	biomarker_for	gene	0.60
GJA1	biomarker_for	gene	0.60
Apoptosis	expressed_in	pathway	0.60
Nf-Κb	expressed_in	pathway	0.60
Oxidative Stress	therapeutic_target	pathway	0.60
CANCER	inhibits	gene	0.60
RNA	inhibits	gene	0.60
PD-1	inhibits	gene	0.60
T Cell	inhibits	cell_type	0.60
Nf-Κb	regulates	pathway	0.60
DIABETES MELLITUS	regulates	gene	0.60
AND	inhibits	gene	0.60
Cytokine	inhibits	protein	0.60
RUNX2	biomarker_for	gene	0.60
Nf-Κb	biomarker_for	pathway	0.60
Insulin	biomarker_for	protein	0.60
Insulin	regulates	protein	0.60
App	regulates	protein	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
ALS	associated_with	disease	0.60
T Cell	expressed_in	cell_type	0.55
TGFBI	co_expressed_with	gene	0.50
DIABETES	associated_with	disease	0.50

Incoming (46)

Source	Relation	Type	Str
MAF	inhibits	gene	0.60
CD8	inhibits	gene	0.60
CD4	inhibits	gene	0.60
CD4	activates	gene	0.60
CD8	activates	gene	0.60
CDKN2A	regulates	gene	0.60
TP53	regulates	gene	0.60
TET2	expressed_in	gene	0.60
MYD88	expressed_in	gene	0.60
KMT2D	expressed_in	gene	0.60
STAT3	regulates	gene	0.60
DDX3X	expressed_in	gene	0.60
RB1	regulates	gene	0.60
GNA13	expressed_in	gene	0.60
REL	regulates	gene	0.60
TYMP	biomarker_for	gene	0.60
TNF	biomarker_for	gene	0.60
DISC1	biomarker_for	gene	0.60
GJA1	regulates	gene	0.60
CD44	regulates	gene	0.60
TGFBI	regulates	gene	0.60
NF-ΚB	expressed_in	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
CANCER	inhibits	gene	0.60
VIRAL INFECTIONS	inhibits	gene	0.60
PD-1	inhibits	gene	0.60
RNA	inhibits	gene	0.60
AND	inhibits	gene	0.60
RUNX2	regulates	gene	0.60
GENES	regulates	gene	0.60
INFLAMMATION	regulates	gene	0.60
INSULIN RESISTANCE	regulates	gene	0.60
NF-ΚB	regulates	gene	0.60
AND	protects_against	gene	0.60
HUB GENES	regulates	gene	0.60
CANCER	regulates	gene	0.60
GJA1	protects_against	gene	0.50
TGFBI	protects_against	gene	0.50
CD44	co_expressed_with	gene	0.50
GJA1	co_expressed_with	gene	0.50
CD8	co_expressed_with	gene	0.50
MAF	co_expressed_with	gene	0.50
CANCER	interacts_with	gene	0.50
GENES	interacts_with	gene	0.50
NF-ΚB	protects_against	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PRDM1

Understanding Entity Pages

Summary

Wiki Pages (7)

PRDM1 Gene

PRDM4 Gene

TGFBI

Thymidine Phosphorylase Protein

GNA13 Gene