Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about IL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Immune Cell Activation | activates | process | 0.95 |
| Pro-inflammatory Cytokine Production | associated_with | process | 0.95 |
| Neutrophils | expressed_in | cell_type | 0.90 |
| Blood-Brain Barrier | causes | cell_type | 0.90 |
| Microglia | expressed_in | cell_type | 0.90 |
| Neuroinflammation | involved_in | process | 0.85 |
| Cognitive Impairment | associated_with | phenotype | 0.85 |
| TNF | inhibits | gene | 0.80 |
| NFkB | interacts_with | pathway | 0.80 |
| TNF | activates | gene | 0.60 |
| NLRP3 | inhibits | gene | 0.60 |
| NTRK2 | inhibits | gene | 0.60 |
| IL6 | inhibits | gene | 0.60 |
| IL6R | inhibits | gene | 0.60 |
| IL6R | associated_with | gene | 0.60 |
| TNFRSF1A | associated_with | gene | 0.60 |
| IL6R | activates | gene | 0.60 |
| NF-kB signaling | participates_in | pathway | 0.60 |
| PI3K-AKT-mTOR signaling | participates_in | pathway | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| T cells | expressed_in | cell_type | 0.60 |
| senescence | participates_in | pathway | 0.60 |
| microglia | expressed_in | cell_type | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||