concept

EXTRACELLULAR VESICLES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EXTRACELLULAR VESICLES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

154Connections

0Hypotheses

4Analyses

48Outgoing

50Incoming

0Experiments

No summary available yet. View on Wiki →

💡 Concept Info

Name	EXTRACELLULAR VESICLES
Summary	Page for Extracellular Vesicles in Neurodegeneration
Key Genes/Proteins	RAB27A
Related Diseases	Sepsis, cancer, TUMOR, Fatty Liver
Related Pathways	Pi3K, Pi3K/Akt

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Corticobasal Syndrome (CBS)

disease · 11374 words

→

Parkinson's Disease

disease · 8807 words

→

Pathway Diagram

graph TD
    EXTRACELLULAR_VESICLES["EXTRACELLULAR VESICLES"]
    EXTRACELLULAR_VESICLES -->|"modulates"| Liver["Liver"]
    EXTRACELLULAR_VESICLES -->|"modulates"| Tumor_Microenvironment["Tumor Microenvironment"]
    EXTRACELLULAR_VESICLES -->|"mediates"| Angiogenesis["Angiogenesis"]
    EXTRACELLULAR_VESICLES -->|"mediates"| Intercellular_Communication["Intercellular Communication"]
    EXTRACELLULAR_VESICLES -->|"mediates"| Metabolic_Dysfunction["Metabolic Dysfunction"]
    EXTRACELLULAR_VESICLES -->|"promotes"| dopaminergic_cell_death["dopaminergic cell death"]
    EXTRACELLULAR_VESICLES -.biomarker for.-> Sarcopenia["Sarcopenia"]
    EXTRACELLULAR_VESICLES -->|"mediates"| Mitochondrial_Targeting["Mitochondrial Targeting"]
    candesartan["candesartan"] -->|"inhibits"| EXTRACELLULAR_VESICLES
    GJA1["GJA1"] -->|"regulates"| EXTRACELLULAR_VESICLES
    EXOSOMES["EXOSOMES"] -->|"interacts"| EXTRACELLULAR_VESICLES
    BLOOD_BRAIN_BARRIER["BLOOD-BRAIN BARRIER"] -->|"interacts"| EXTRACELLULAR_VESICLES
    AKT["AKT"] -->|"regulates"| EXTRACELLULAR_VESICLES
    EXTRACELLULAR_MATRIX["EXTRACELLULAR MATRIX"] -.biomarker for.-> EXTRACELLULAR_VESICLES
    CANCER["CANCER"] -->|"activates"| EXTRACELLULAR_VESICLES

Outgoing (48)

Target	Relation	Type	Str
Metastatic Tumor Microenvironment	associated_with	phenotype	0.95
Mitochondria	transports	cell_type	0.95
Metastatic Tumor Microenvironment	promotes	phenotype	0.95
TARDBP	transports	protein	0.95
MAPT	transports	protein	0.95
Fatty Liver	associated_with	disease	0.95
Fatty Liver	expressed_in	disease	0.95
tumor microenvironment	promotes	phenotype	0.92
Microglia	interacts_with	cell_type	0.92
Liver	modulates	cell_type	0.90
Intercellular Communication	mediates	process	0.90
Liver	targets	cell_type	0.90
metastasis	promotes	process	0.90
miR-206-3p	associated_with	drug	0.90
Tumor Microenvironment	modulates	phenotype	0.90
Angiogenesis	mediates	process	0.90
Metabolic Dysfunction	mediates	phenotype	0.88
metabolic maturation	mediates	phenotype	0.88
dopaminergic cell death	promotes	process	0.87
angiogenesis	promotes	process	0.87
Functional Recovery	associated_with	phenotype	0.85
Disease Biomarker	associated_with	biomarker	0.85
Mitochondrial Targeting	mediates	mechanism	0.85
Mitochondrial Protection	associated_with	process	0.85
Tumor Metastasis	mediates	process	0.85
Sarcopenia	biomarker_for	disease	0.85
Alzheimer Disease	therapeutic_target	disease	0.85
Immune System	participates_in	biological_process	0.80
Antigen Presentation	participates_in	biological_process	0.80
Physiological Functions	associated_with	biological_process	0.80
Organ Biodistribution	associated_with	phenotype	0.80
Tissue Repair	mediates	process	0.80
Immune Modulation	mediates	process	0.80
cryptic peptides	expressed_in	compound	0.80
Systemic metabolism	regulates	pathway	0.80
immune cell infiltration	mediates	process	0.80
amyloid-beta	mediates	compound	0.80
tau	mediates	protein	0.80
LGALS9	mediates	protein	0.80
systemic inflammation	promotes	process	0.78
IL12B	upregulates	gene	0.75
Neurodegeneration	contributes_to	disease	0.75
Drug Delivery	associated_with	biological_process	0.70
phosphorylated tau	mediates	protein	0.70
cell-to-cell communication	regulates	process	0.70
quality control	promotes	process	0.70
Neuroinflammation	modulates	process	0.60
CHRONIC INFLAMMATION	activates	concept	0.50

Incoming (106)

Source	Relation	Type	Str
P2RX7	regulates	gene	0.95
fatty liver	promotes	phenotype	0.95
MIR130A	expressed_in	gene	0.92
TGFB1	expressed_in	protein	0.90
Brown Adipose Tissue	associated_with	cell_type	0.90
ITGAV	targets	gene	0.90
ITGB8	targets	gene	0.90
candesartan	inhibits	drug	0.88
hepatic steatosis	associated_with	disease	0.85
cryptic peptides	expressed_in	compound	0.85
Sarcopenia	associated_with	disease	0.85
Cancer	associated_with	disease	0.85
GJA1	involved_in	gene	0.80
GJA1	regulates	gene	0.70
motor skill learning	modulates	process	0.70
LRRK2	promotes	protein	0.70
Pi3K	interacts_with	pathway	0.50
Pi3K/Akt	interacts_with	pathway	0.50
PERICYTE	interacts_with	concept	0.50
ANGPT1	interacts_with	concept	0.50
Sepsis	interacts_with	disease	0.50
PI3K/AKT PATHWAY	interacts_with	concept	0.50
PERICYTE	associated_with	concept	0.50
PERICYTES	associated_with	concept	0.50
RAB27A	activates	protein	0.50
cancer	activates	disease	0.50
TUMOR	activates	disease	0.50
Tumor Microenvironment	activates	process	0.50
Fatty Liver	activates	disease	0.50
Autophagy	regulates	process	0.50
GJA1	regulates	gene	0.50
Cardiovascular	associated_with	disease	0.50
Sod1	activates	gene	0.50
amyotrophic lateral sclerosis	activates	gene	0.50
COMPLEMENT	activates	pathway	0.50
Sod1	associated_with	gene	0.50
Stem Cell	associated_with	cell_type	0.50
Autophagy	activates	process	0.50
PARKINSON	activates	gene	0.50
Parkinson's Disease	activates	disease	0.50
disease	activates	disease	0.50
PARKINSON'S	activates	concept	0.50
DOPAMINE	activates	concept	0.50
PARKINSON	interacts_with	gene	0.50
PARKINSON'S	interacts_with	concept	0.50
Cellular Senescence	associated_with	cell_type	0.50
STEM CELLS	associated_with	concept	0.50
ENDOTHELIAL	associated_with	concept	0.50
TUMOR	associated_with	disease	0.50
MICRORNAS	associated_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (4)

Scientific analyses that reference this entity

Which tau propagation mechanism predominates in different brain regions and dise

neurodegeneration | 2026-04-07 | 0 hypotheses

Trans-synaptic tau spreading and propagation mechanisms in AD

neuroscience | 2026-04-04 | 0 hypotheses

Extracellular vesicle biomarkers for early AD detection

neurodegeneration | 2026-04-02 | 0 hypotheses

Tau propagation mechanisms and therapeutic interception points

neurodegeneration | 2026-04-02 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

EXTRACELLULAR VESICLES

Understanding Entity Pages

Wiki Pages (21)