Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BBB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
BBB is an entity related to neurodegeneration research. Key relationships include: co discussed, associated with, regulates. Associated with ALS, ALZHEIMER'S DISEASE, PARKINSON'S DISEASE. Connected to 70 entities in the SciDEX knowledge graph.
Knowledge base pages for this entity
graph TD
BBB["Blood-Brain Barrier"] -->|"Components"| EC["Endothelial Cells"]
BBB -->|"Components"| TJ["Tight Junctions"]
BBB -->|"Components"| Pericytes["Pericytes"]
BBB -->|"Components"| Astrocytes["Astrocytic End-feet"]
EC -->|"Express"| Transporters["ABC Transporters"]
TJ -->|"Seal"| Gaps["Paracellular Gaps"]
BBB -->|"Regulates"| Influx["Nutrient Influx"]
BBB -->|"Regulates"| Efflux["Waste Efflux"]
Aging -.Causes.-> Breakdown["BBB Breakdown"]
Breakdown -.Allows.-> Entry["Toxin Entry"]
Entry -.Contributes to.-> ND["Neurodegeneration"]| Target | Relation | Type | Str |
|---|---|---|---|
| BLOOD-BRAIN BARRIER | co_discussed | entity | 0.50 |
| ENDOTHELIAL | co_discussed | entity | 0.50 |
| STROKE | co_discussed | entity | 0.50 |
| CLDN5 | co_discussed | entity | 0.50 |
| BECN1 | co_discussed | entity | 0.50 |
| MMP2 | co_discussed | entity | 0.50 |
| MMP9 | co_discussed | entity | 0.50 |
| PERICYTE | co_discussed | entity | 0.50 |
| PERICYTES | co_discussed | entity | 0.50 |
| HIPPOCAMPUS | co_discussed | entity | 0.50 |
| STING | co_discussed | entity | 0.50 |
| TAU | co_discussed | entity | 0.50 |
| MICROGLIA | co_discussed | entity | 0.50 |
| NEUROINFLAMMATION | co_discussed | entity | 0.50 |
| COMPLEMENT | co_discussed | entity | 0.50 |
| NEURON | co_discussed | entity | 0.50 |
| LRP1 | co_discussed | entity | 0.50 |
| T CELL | co_discussed | entity | 0.50 |
| CHLOROQUINE | associated_with | drug | 0.45 |
| ETANERCEPT | associated_with | drug | 0.45 |
| SELEGILINE | associated_with | drug | 0.45 |
| KETAMINE | associated_with | drug | 0.45 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CLDN5 | regulates | gene | 0.90 |
| autophagy | alleviates | process | 0.90 |
| AUTOPHAGY | regulates | pathway | 0.72 |
| HYPOXIA | causes | phenotype | 0.72 |
| CLAUDIN5 | regulates | protein | 0.72 |
| ENDOTHELIAL CELLS | protects_against | cell_type | 0.65 |
| MONOCYTES | interacts_with | cell_type | 0.64 |
| STROKE | causes | disease | 0.64 |
| AUTOPHAGY | co_discussed | entity | 0.50 |
| APOPTOSIS | co_discussed | entity | 0.50 |
| ALZHEIMER | co_discussed | entity | 0.50 |
| ALZHEIMER'S | co_discussed | entity | 0.50 |
| APOE | co_discussed | entity | 0.50 |
| ASTROCYTE | co_discussed | entity | 0.50 |
| ASTROCYTES | co_discussed | entity | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Synthetic Biology BBB Endothelial Cell Reprogramming | 0.565 | neurodegeneration | Blood-brain barrier transport mechanisms |
| Time-Dependent BBB Repair Strategy | 0.550 | - | Blood-brain barrier tight junction disru |
| SIRT1-Mediated Epigenetic Restoration of MFSD2A Expression R | 0.498 | neuropharmacology | What determines blood-brain barrier pene |
| Piezoelectric Nanochannel BBB Disruption | 0.414 | neurodegeneration | Blood-brain barrier transport mechanisms |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-16 | 7 hypotheses Top: 0.780
drug delivery | 2026-04-15 | 0 hypotheses
neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.675
neuropharmacology | 2026-04-13 | 2 hypotheses Top: 0.552
neuropharmacology | 2026-04-12 | 1 hypotheses Top: 0.480
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Dolutegravir induces endoplasmic reticulum stress at the blood-brain barrier. [PMID:39985305] | Huang C, Qu QR, Hoque MT, Bendayan R | FASEB J | 2025 | 1 |
| Profiling Tight Junction Protein Expression in Brain Vascular Malformations. [PMID:40429705] | Pedrosa L, Mosteiro A, Reyes L, Amaro S, | Int J Mol Sci | 2025 | 1 |
| Autophagy alleviates hypoxia-induced blood-brain barrier injury via regulation o [PMID:33280500] | Yang Z, Lin P, Chen B, Zhang X, Xiao W, | Autophagy | 2021 | 1 |
| ROS-responsive nanogels for brain targeted delivery of icariin in the treatment [PMID:41197818] | ["Li X", "Huang J", "Zhou Y", "Chen X", | International journal of pharm | 2026 | 0 |
| Claudins proteins in brain tumors: expression patterns and therapeutic target. [PMID:41399659] | ["Romanowicz A", "\u0141ukaszewicz-Zaj\u | Biochemia medica | 2026 | 0 |
| Testicular Gap (CX43) and Tight Junction (OCLN, CLDN3, 5 and 11) Components in t [PMID:41594443] | Goericke-Pesch S, Röhrs L, Wallrabenstei | Animals : an open access journ | 2026 | 0 |
| Stress-induced mitochondrial fragmentation in endothelial cells disrupts blood-r [PMID:40994007] | ["Cueva Vargas J", "Belforte N", "Vidal- | Molecular therapy : the journa | 2026 | 0 |
| Bionanoconjugates in Neurodegeneration: Peptide-Nanoparticle Alliances for Next- [PMID:41199078] | ["Ranjitha V", "Kumar A", "Kaalappa P"] | Pharmaceutical research | 2025 | 0 |
| Artemether Improves Aβ [PMID:40493345] | ["Cai J", "Liu Y", "Gong L", "Deng S", " | Molecular neurobiology | 2025 | 0 |
| Stress-induced mitochondrial fragmentation in endothelial cells disrupts blood-r [PMID:39975311] | ["Cueva-Vargas J", "Belforte N", "Vidal- | bioRxiv : the preprint server | 2025 | 0 |
| Mesenchymal Stem Cells Restore Endothelial Integrity and Alleviate Emotional Imp [PMID:40244194] | ["Chen A", "Duan Y", "Zhou S", "Du F", " | International journal of molec | 2025 | 0 |
| Claudin-1 impairs blood-brain barrier by downregulating endothelial junctional p [PMID:40018968] | Gowrikumar S, Tarudji A, McDonald BZ, Ba | Tissue barriers | 2025 | 0 |
| Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746] | ["Sanadgol N", "Abedi M", "Hashemzaei M" | Journal of nanobiotechnology | 2025 | 0 |
| Antiretroviral drugs efavirenz, dolutegravir and bictegravir dysregulate blood-b [PMID:36969875] | ["Huang C", "Hoque T", "Bendayan R"] | Frontiers in pharmacology | 2023 | 0 |
| Cathepsin S is a novel target for age-related dry eye. [PMID:34910926] | ["Yu Z", "Li J", "Govindarajan G", "Hamm | Experimental eye research | 2022 | 0 |
| Intrinsic functional neuron-type selectivity of transcranial focused ultrasound [PMID:33947867] | ["Yu K", "Niu X", "Krook-Magnuson E", "H | Nature communications | 2021 | 0 |
| NK cells for cancer immunotherapy. [PMID:31907401] | ["Shimasaki N", "Jain A", "Campana D"] | Nature reviews. Drug discovery | 2020 | 0 |
| Potent and specific MTH1 inhibitors targeting gastric cancer. [PMID:31164636] | ["Zhou W", "Ma L", "Yang J", "Qiao H", " | Cell death & disease | 2019 | 0 |
| Clinical factors associated with worse quality-of-life scores in United States t [PMID:30898373] | ["Goswami S", "Peipert B", "Mongelli M", | Surgery | 2019 | 0 |
| Arabidopsis Duodecuple Mutant of PYL ABA Receptors Reveals PYL Repression of ABA [PMID:29898403] | ["Zhao Y", "Zhang Z", "Gao J", "Wang P", | Cell reports | 2018 | 0 |