protein

CTCF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CTCF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

81Connections

0Hypotheses

1Analyses

50Outgoing

28Incoming

0Experiments

1Debates

Summary

CTCF is a protein involved in neurodegeneration research. Key relationships include: associated with, regulates, activates. Associated with Aging, Als, Anxiety. Connected to 62 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	CTCF
Full Name	CCCTC-Binding Factor
Chromosome	16q22.1
Function	The CTCF gene encodes CCCTC-Binding Factor, a highly conserved zinc finger transcription factor that is one of the most important architectural proteins in the mammalian genome.
Primary Expression	both excitatory and inhibitory neurons throughout development and in adulthood
Molecular Weight	83 kDa
Pathways	Autophagy, Cell Cycle, Epigenetic, Inflammasome, Neurogenesis
UniProt ID	P49711
NCBI Gene ID	1065
Ensembl ID	ENSG00000102974
OMIM	114167
GeneCards	CTCF
Human Protein Atlas	CTCF
Amyotrophic Lateral Sclerosis (ALS)	Altered CTCF binding and chromatin architecture have been reported in ALS, potentially affecting expression of RNA metabolism genes.
Huntington's Disease (HD)	CTCF function may be impaired by mutant huntingtin, leading to dysregulation of transcriptional programs.
Associated Diseases	Cancer, chromatin remodeling reach, insulated neighborhoods
Interactions	ANXIETY, BDNF, BNIP3L, CANCER, DNA, E2F3
KG Connections	81 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CTCF — AlphaFold P49711 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CTCF["CTCF"]
    Ms{"Ms"}
    CTCF -->|"regulates"| Ms
    Cancer{"Cancer"}
    CTCF -->|"regulates"| Cancer
    Tumor{"Tumor"}
    CTCF -->|"regulates"| Tumor
    Als{"Als"}
    CTCF -->|"regulates"| Als
    Aging{"Aging"}
    CTCF -->|"regulates"| Aging
    Carcinoma{"Carcinoma"}
    CTCF -->|"activates"| Carcinoma
    CTCF -->|"therapeutic target"| Ms
    CTCF -->|"activates"| Cancer
    CTCF -->|"activates"| Tumor
    KLF2["KLF2"]
    CTCF -->|"regulates"| KLF2
    PARP1["PARP1"]
    CTCF -->|"activates"| PARP1
    Inflammasome(["Inflammasome"])
    CTCF -->|"regulates"| Inflammasome
    P53["P53"]
    P53 -->|"regulates"| CTCF
    CANCER["CANCER"]
    CANCER -->|"regulates"| CTCF
    PARP1 -->|"activates"| CTCF
    KLF2 -->|"regulates"| CTCF
    BNIP3L["BNIP3L"]
    BNIP3L -->|"interacts with"| CTCF
    HNRNPU["HNRNPU"]
    HNRNPU -->|"interacts with"| CTCF
    MYC["MYC"]
    MYC -->|"activates"| CTCF
    CSF1["CSF1"]
    CSF1 -->|"therapeutic target"| CTCF
    CANCER -->|"activates"| CTCF
    style CTCF fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (53)

Target	Relation	Type	Str
chromatin interactions	regulates	phenotype	0.70
chromatin interactions across TAD boundaries	modulates	mechanism	0.70
chromatin remodeling reach	associated_with	phenotype	0.70
insulated neighborhoods	associated_with	phenotype	0.70
ALS	regulates	disease	0.65
Cancer	associated_with	disease	0.65
Ms	regulates	disease	0.65
Anxiety	inhibits	disease	0.65
Als	inhibits	disease	0.65
Cancer	regulates	disease	0.65
Tumor	regulates	disease	0.65
Als	regulates	disease	0.65
Aging	regulates	disease	0.65
Carcinoma	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Epigenetic	activates	pathway	0.60
PARP1	activates	gene	0.60
Tgf-Β	regulates	pathway	0.60
Cell Cycle	regulates	pathway	0.60
E2F3	regulates	gene	0.60
Rb	regulates	protein	0.60
LC3	associated_with	gene	0.60
AKT	associated_with	gene	0.60
KLF2	regulates	gene	0.60
Notch	regulates	pathway	0.60
Inflammasome	regulates	pathway	0.60
AUTOPHAGY	regulates	gene	0.60
Epigenetic	interacts_with	pathway	0.60
Autophagy	regulates	pathway	0.60
Dna Methylation	interacts_with	pathway	0.60
CANCER	associated_with	gene	0.60
MTORC1	associated_with	gene	0.60
EP300	interacts_with	gene	0.60
Lysosomal Degradation	associated_with	pathway	0.60
Autophagy	associated_with	pathway	0.60
Mtor	associated_with	pathway	0.60
Apoptosis	associated_with	pathway	0.60
NADH	inhibits	gene	0.60
DNA	inhibits	gene	0.60
Fibroblast	regulates	cell_type	0.60
IGF2BP2	activates	gene	0.60
Epigenetic	inhibits	pathway	0.60
NOTCH	regulates	gene	0.60
Neurogenesis	regulates	pathway	0.60
Wnt	regulates	pathway	0.60
CSF1R	therapeutic_target	gene	0.60
SMPD1	associated_with	gene	0.60
BCL2	associated_with	gene	0.60

Incoming (28)

Source	Relation	Type	Str
PARP1	activates	gene	0.60
P53	regulates	gene	0.60
CANCER	regulates	gene	0.60
NAD	inhibits	gene	0.60
ANXIETY	inhibits	gene	0.60
BNIP3L	interacts_with	gene	0.60
PNPLA6	associated_with	gene	0.60
BAX	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
RPS6	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
KLF2	regulates	gene	0.60
GFP	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
DMSO	associated_with	gene	0.60
MAP1LC3	associated_with	gene	0.60
HNRNPU	interacts_with	gene	0.60
MYC	activates	gene	0.60
CSF1	therapeutic_target	gene	0.60
E2F3	regulates	gene	0.60
CANCER	activates	gene	0.60
GENES	regulates	gene	0.60
NOTCH	regulates	gene	0.60
BDNF	activates	gene	0.60
SIRT1	inhibits	gene	0.60
WNT	regulates	gene	0.60
E2F3	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Do different priming stimuli create distinct chromatin landscapes or converge on

epigenetics | 2026-04-10 | 3 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The debate presented conflicting evidence for convergent vs. stimulus-specific c

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

Related Research

Hypotheses and analyses mentioning CTCF in their description or question text

No additional research found