Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about P62/SQSTM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | P62/SQSTM1 |
| Molecular Weight | 62 kDa |
| Amino Acids | 440 aa |
| Pathways | NF-κB, NF-κB signaling |
| Associated Diseases | Alzheimer'S Disease, ALS |
| Interactions | NBR1, WAS, MYOT, P62, NEMO, CGAS |
| KG Connections | 40 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
P62_SQSTM1["<b>P62/SQSTM1</b>"]
NBR1["NBR1"]
P62_SQSTM1 -->|"activates"| NBR1
SQSTM1["SQSTM1"]
P62_SQSTM1 -->|"co discussed"| SQSTM1
STING["STING"]
P62_SQSTM1 -->|"co discussed"| STING
UBIQUITIN["UBIQUITIN"]
P62_SQSTM1 -->|"co discussed"| UBIQUITIN
WAS["WAS"]
P62_SQSTM1 -->|"activates"| WAS
MYOT["MYOT"]
P62_SQSTM1 -->|"activates"| MYOT
P62["P62"]
P62_SQSTM1 -->|"activates"| P62
Cgas_Sting["Cgas-Sting"]
P62_SQSTM1 -->|"activates"| Cgas_Sting
NF__B["NF-kappaB"]
P62_SQSTM1 -->|"activates"| NF__B
Toll_Like_Receptor["Toll-Like Receptor"]
P62_SQSTM1 -->|"activates"| Toll_Like_Receptor
SYNUCLEIN["SYNUCLEIN"]
P62_SQSTM1 -->|"activates"| SYNUCLEIN
NEMO["NEMO"]
P62_SQSTM1 -->|"interacts with"| NEMO
HSP27["HSP27"]
P62_SQSTM1 -->|"regulates"| HSP27
SELECTIVE_AUTOPHAGY["SELECTIVE AUTOPHAGY"]
P62_SQSTM1 -->|"regulates"| SELECTIVE_AUTOPHAGY
BRCA1["BRCA1"]
P62_SQSTM1 -->|"associated with"| BRCA1
Proteins["Proteins"]
P62_SQSTM1 -->|"associated with"| Proteins
NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"]
P62_SQSTM1 -->|"activates"| NEURODEGENERATIVE_DISORDERS
disease["disease"]
P62_SQSTM1 -->|"activates"| disease
AUTOPHAGY["AUTOPHAGY"]
AUTOPHAGY -->|"co discussed"| P62_SQSTM1
BRCA1["BRCA1"]
BRCA1 -->|"co discussed"| P62_SQSTM1
DES["DES"]
DES -->|"co discussed"| P62_SQSTM1
DNAJB6["DNAJB6"]
DNAJB6 -->|"co discussed"| P62_SQSTM1
FLNC["FLNC"]
FLNC -->|"co discussed"| P62_SQSTM1
Autophagy["Autophagy"]
Autophagy -->|"activates"| P62_SQSTM1
CGAS["CGAS"]
CGAS -->|"activates"| P62_SQSTM1
SQSTM1["SQSTM1"]
SQSTM1 -->|"activates"| P62_SQSTM1
TBK1["TBK1"]
TBK1 -->|"activates"| P62_SQSTM1
STING["STING"]
STING -->|"activates"| P62_SQSTM1
microglia["microglia"]
microglia -->|"activates"| P62_SQSTM1
TLR4["TLR4"]
TLR4 -->|"activates"| P62_SQSTM1| Target | Relation | Type | Str |
|---|---|---|---|
| NBR1 | activates | gene | 0.50 |
| SQSTM1 | co_discussed | gene | 0.50 |
| STING | co_discussed | gene | 0.50 |
| UBIQUITIN | co_discussed | protein | 0.50 |
| WAS | activates | protein | 0.50 |
| MYOT | activates | gene | 0.50 |
| P62 | activates | protein | 0.50 |
| Cgas-Sting | activates | pathway | 0.50 |
| NF-κB | activates | concept | 0.50 |
| Toll-Like Receptor | activates | pathway | 0.50 |
| SYNUCLEIN | activates | concept | 0.50 |
| NEMO | interacts_with | protein | 0.50 |
| HSP27 | regulates | protein | 0.50 |
| SELECTIVE AUTOPHAGY | regulates | concept | 0.50 |
| BRCA1 | associated_with | protein | 0.50 |
| Proteins | associated_with | protein | 0.50 |
| NEURODEGENERATIVE DISORDERS | activates | concept | 0.50 |
| disease | activates | disease | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AUTOPHAGY | co_discussed | gene | 0.50 |
| BRCA1 | co_discussed | protein | 0.50 |
| DES | co_discussed | gene | 0.50 |
| DNAJB6 | co_discussed | gene | 0.50 |
| FLNC | co_discussed | gene | 0.50 |
| Autophagy | activates | process | 0.50 |
| CGAS | activates | protein | 0.50 |
| SQSTM1 | activates | gene | 0.50 |
| TBK1 | activates | gene | 0.50 |
| STING | activates | gene | 0.50 |
| microglia | activates | cell_type | 0.50 |
| TLR4 | activates | gene | 0.50 |
| OPTN | interacts_with | gene | 0.50 |
| SQSTM1 | interacts_with | gene | 0.50 |
| Autophagy | regulates | process | 0.50 |
| SQSTM1 | regulates | gene | 0.50 |
| SQSTM1 | associated_with | gene | 0.50 |
| DNAJB6 | associated_with | gene | 0.50 |
| FLNC | associated_with | gene | 0.50 |
| MYOT | associated_with | gene | 0.50 |
| NBR1 | associated_with | gene | 0.50 |
| Autophagy | interacts_with | process | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||